selected publications
- Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies. The Journal of experimental medicine. 2024 Academic Article GET IT
- Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site. Science immunology. 2024 Academic Article GET IT
- Immunization with germ line-targeting SOSIP trimers elicits broadly neutralizing antibody precursors in infant macaques. Science immunology. 2024 Academic Article GET IT
- The harms of promoting the lab leak hypothesis for SARS-CoV-2 origins without evidence. Journal of virology. 2024 Academic Article GET IT
-
Progress on priming HIV-1 immunity.
Science (New York, N.Y.).
2024
Comment
GET IT
Times cited: 1 - HIV BG505 SOSIP.664 trimer with 3M-052-AF/alum induces human autologous tier-2 neutralizing antibodies. 2024 GET IT
- Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques. 2023 GET IT
- Glycan heterogeneity as a cause of the persistent fraction in HIV-1 neutralization. PLoS pathogens. 2023 Academic Article GET IT
- Correction: HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers. 2023 GET IT
-
Conformational antigenic heterogeneity as a cause of the persistent fraction in HIV-1 neutralization.
Retrovirology.
2023
Academic Article
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Times cited: 2 - Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions. Cell reports. Medicine. 2023 Academic Article GET IT
- Longitudinal antibody response kinetics following SARS-CoV-2 mRNA vaccination in pregnant and non-pregnant persons. American journal of obstetrics & gynecology MFM. 2022 Academic Article GET IT
-
Asthma 17q21 polymorphism associates with decreased risk of COVID-19 in children.
Pediatric pulmonology.
2022
Letter
GET IT
Times cited: 2 - Structural dynamics reveal isolate-specific differences at neutralization epitopes on HIV Env. iScience. 2022 Academic Article GET IT
- Broad and ultra-potent cross-clade neutralization of HIV-1 by a vaccine-induced CD4 binding site bovine antibody. Cell reports. Medicine. 2022 Academic Article GET IT
- The glycan hole area of HIV-1 envelope trimers contributes prominently to the induction of autologous neutralization. Journal of virology. 2021 Academic Article GET IT
- Beta testing the monkey model. Nature immunology. 2021 Comment GET IT
- Emerging SARS-CoV-2 variants of concern evade humoral immune responses from infection and vaccination. Science advances. 2021 Academic Article GET IT
- Antibody responses induced by SHIV infection are more focused than those induced by soluble native HIV-1 envelope trimers in non-human primates. PLoS pathogens. 2021 Academic Article GET IT
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Serologic response to mRNA COVID-19 vaccination in lymphoma patients.
American journal of hematology.
2021
Letter
GET IT
Times cited: 24 - Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers. NPJ vaccines. 2021 Academic Article GET IT
- Antibodies from Rabbits Immunized with HIV-1 Clade B SOSIP Trimers Can Neutralize Multiple Clade B Viruses by Destabilizing the Envelope Glycoprotein. Journal of virology. 2021 Academic Article GET IT
-
Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM.
Nature communications.
2021
Academic Article
GET IT
Times cited: 31 - Predictors of Nonseroconversion after SARS-CoV-2 Infection. Emerging infectious diseases. 2021 Academic Article GET IT
-
Antibody Responses to SARS-CoV-2 mRNA Vaccines Are Detectable in Saliva.
Pathogens & immunity.
2021
Academic Article
GET IT
Times cited: 83 -
Postconvalescent SARS-CoV-2 IgG and Neutralizing Antibodies are Elevated in Individuals with Poor Metabolic Health.
The Journal of clinical endocrinology and metabolism.
2021
Academic Article
GET IT
Times cited: 22 -
Enhancing glycan occupancy of soluble HIV-1 envelope trimers to mimic the native viral spike.
Cell reports.
2021
Academic Article
GET IT
Times cited: 3 -
Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles.
NPJ vaccines.
2021
Academic Article
GET IT
Times cited: 31 -
Testing-on-a-probe biosensors reveal association of early SARS-CoV-2 total antibodies and surrogate neutralizing antibodies with mortality in COVID-19 patients.
Biosensors & bioelectronics.
2021
Academic Article
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Times cited: 18 -
High-resolution mapping of the neutralizing and binding specificities of polyclonal sera post-HIV Env trimer vaccination.
eLife.
2021
Academic Article
GET IT
Times cited: 11 -
Neutralizing Antibody Responses Induced by HIV-1 Envelope Glycoprotein SOSIP Trimers Derived from Elite Neutralizers.
Journal of virology.
2020
Academic Article
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Times cited: 13 -
Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates.
PLoS pathogens.
2020
Academic Article
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Times cited: 50 -
COVID-19 Vaccines: "Warp Speed" Needs Mind Melds, Not Warped Minds.
Journal of virology.
2020
Information Resource
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Times cited: 67 -
Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens.
PLoS pathogens.
2020
Academic Article
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Times cited: 43 -
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens.
eLife.
2020
Academic Article
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Times cited: 99 -
T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers.
Nature medicine.
2020
Academic Article
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Times cited: 113 -
Env Exceptionalism: Why Are HIV-1 Env Glycoproteins Atypical Immunogens?.
Cell host & microbe.
2020
Information Resource
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Times cited: 39 -
Neutralizing Antibody Induction by HIV-1 Envelope Glycoprotein SOSIP Trimers on Iron Oxide Nanoparticles May Be Impaired by Mannose Binding Lectin.
Journal of virology.
2020
Academic Article
GET IT
Times cited: 26 - SOS and IP Modifications Predominantly Affect the Yield but Not Other Properties of SOSIP.664 HIV-1 Env Glycoprotein Trimers. Journal of virology. 2019 Academic Article GET IT
-
Antibody Responses Elicited by Immunization with BG505 Trimer Immune Complexes.
Journal of virology.
2019
Academic Article
GET IT
Times cited: 13 -
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle.
Nature communications.
2019
Academic Article
GET IT
Times cited: 126 -
Conformational Plasticity in the HIV-1 Fusion Peptide Facilitates Recognition by Broadly Neutralizing Antibodies.
Cell host & microbe.
2019
Academic Article
GET IT
Times cited: 36 -
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence.
Nature communications.
2019
Academic Article
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Times cited: 99 -
Optimizing the production and affinity purification of HIV-1 envelope glycoprotein SOSIP trimers from transiently transfected CHO cells.
PloS one.
2019
Academic Article
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Times cited: 16 -
Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide.
Nature communications.
2019
Academic Article
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Times cited: 22 -
Developability Assessment of Physicochemical Properties and Stability Profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 Envelope Glycoprotein Trimers as Candidate Vaccine Antigens.
Journal of pharmaceutical sciences.
2019
Academic Article
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Times cited: 17 -
Stabilization of the V2 loop improves the presentation of V2 loop-associated broadly neutralizing antibody epitopes on HIV-1 envelope trimers.
The Journal of biological chemistry.
2019
Academic Article
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Times cited: 14 -
Closing and Opening Holes in the Glycan Shield of HIV-1 Envelope Glycoprotein SOSIP Trimers Can Redirect the Neutralizing Antibody Response to the Newly Unmasked Epitopes.
Journal of virology.
2019
Academic Article
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Times cited: 54 -
Site-Specific Glycosylation of Virion-Derived HIV-1 Env Is Mimicked by a Soluble Trimeric Immunogen.
Cell reports.
2018
Academic Article
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Times cited: 91 -
Effects of Adjuvants on HIV-1 Envelope Glycoprotein SOSIP Trimers In Vitro.
Journal of virology.
2018
Academic Article
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Times cited: 31 -
Structural and immunologic correlates of chemically stabilized HIV-1 envelope glycoproteins.
PLoS pathogens.
2018
Academic Article
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Times cited: 22 -
Immunogenicity in Rabbits of HIV-1 SOSIP Trimers from Clades A, B, and C, Given Individually, Sequentially, or in Combination.
Journal of virology.
2018
Academic Article
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Times cited: 60 -
Epitopes for neutralizing antibodies induced by HIV-1 envelope glycoprotein BG505 SOSIP trimers in rabbits and macaques.
PLoS pathogens.
2018
Academic Article
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Times cited: 79 -
Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages.
Journal of proteome research.
2018
Academic Article
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Times cited: 19 -
cGMP production and analysis of BG505 SOSIP.664, an extensively glycosylated, trimeric HIV-1 envelope glycoprotein vaccine candidate.
Biotechnology and bioengineering.
2017
Academic Article
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Times cited: 58 -
Stabilization of the gp120 V3 loop through hydrophobic interactions reduces the immunodominant V3-directed non-neutralizing response to HIV-1 envelope trimers.
The Journal of biological chemistry.
2017
Academic Article
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Times cited: 32 -
High-Throughput Protein Engineering Improves the Antigenicity and Stability of Soluble HIV-1 Envelope Glycoprotein SOSIP Trimers.
Journal of virology.
2017
Academic Article
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Times cited: 21 -
Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.
The Journal of experimental medicine.
2017
Academic Article
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Times cited: 129 -
Improving the Immunogenicity of Native-like HIV-1 Envelope Trimers by Hyperstabilization.
Cell reports.
2017
Academic Article
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Times cited: 129 -
HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers.
PloS one.
2017
Academic Article
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Times cited: 14 -
Open and closed structures reveal allostery and pliability in the HIV-1 envelope spike.
Nature.
2017
Academic Article
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Times cited: 179 -
Reducing V3 Antigenicity and Immunogenicity on Soluble, Native-Like HIV-1 Env SOSIP Trimers.
Journal of virology.
2017
Academic Article
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Times cited: 39 -
Improving the Expression and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers by Targeted Sequence Changes.
Journal of virology.
2017
Academic Article
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Times cited: 25 -
Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers.
Journal of virology.
2017
Academic Article
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Times cited: 70 -
Recognition of HIV-inactivating peptide triazoles by the recombinant soluble Env trimer, BG505 SOSIP.664.
Proteins.
2017
Academic Article
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Times cited: 7 -
Publishing: Journals, do your own formatting.
Nature.
2017
Article
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Times cited: 3 -
Molecular Architecture of the Cleavage-Dependent Mannose Patch on a Soluble HIV-1 Envelope Glycoprotein Trimer.
Journal of virology.
2017
Academic Article
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Times cited: 60 -
Native-like Env trimers as a platform for HIV-1 vaccine design.
Immunological reviews.
2017
Information Resource
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Times cited: 182 -
Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer.
Cell reports.
2016
Academic Article
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Times cited: 131 -
HIV's Achilles' Heel.
Scientific American.
2016
Academic Article
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Times cited: 6 -
An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability.
Nature microbiology.
2016
Academic Article
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Times cited: 117 -
Sustained antigen availability during germinal center initiation enhances antibody responses to vaccination.
Proceedings of the National Academy of Sciences of the United States of America.
2016
Academic Article
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Times cited: 271 -
Sequential and Simultaneous Immunization of Rabbits with HIV-1 Envelope Glycoprotein SOSIP.664 Trimers from Clades A, B and C.
PLoS pathogens.
2016
Academic Article
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Times cited: 118 -
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
PLoS pathogens.
2016
Academic Article
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Times cited: 222 -
Composition and Antigenic Effects of Individual Glycan Sites of a Trimeric HIV-1 Envelope Glycoprotein.
Cell reports.
2016
Academic Article
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Times cited: 208 -
HIV-1 Envelope Trimer Design and Immunization Strategies To Induce Broadly Neutralizing Antibodies.
Trends in immunology.
2016
Information Resource
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Times cited: 81 -
Native Conformation and Canonical Disulfide Bond Formation Are Interlinked Properties of HIV-1 Env Glycoproteins.
Journal of virology.
2015
Academic Article
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Times cited: 26 -
Immunogenicity of Stabilized HIV-1 Envelope Trimers with Reduced Exposure of Non-neutralizing Epitopes.
Cell.
2015
Academic Article
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Times cited: 274 -
Affinity Maturation of a Potent Family of HIV Antibodies Is Primarily Focused on Accommodating or Avoiding Glycans.
Immunity.
2015
Academic Article
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Times cited: 166 -
A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo.
PLoS pathogens.
2015
Academic Article
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Times cited: 41 -
Chemical Cross-Linking Stabilizes Native-Like HIV-1 Envelope Glycoprotein Trimer Antigens.
Journal of virology.
2015
Academic Article
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Times cited: 29 -
Binding of inferred germline precursors of broadly neutralizing HIV-1 antibodies to native-like envelope trimers.
Virology.
2015
Academic Article
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Times cited: 37 -
Presenting native-like HIV-1 envelope trimers on ferritin nanoparticles improves their immunogenicity.
Retrovirology.
2015
Academic Article
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Times cited: 146 -
Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.
Nature communications.
2015
Academic Article
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Times cited: 72 -
Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens.
Proceedings of the National Academy of Sciences of the United States of America.
2015
Academic Article
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Times cited: 105 -
Influences on the Design and Purification of Soluble, Recombinant Native-Like HIV-1 Envelope Glycoprotein Trimers.
Journal of virology.
2015
Academic Article
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Times cited: 72 -
Murine Antibody Responses to Cleaved Soluble HIV-1 Envelope Trimers Are Highly Restricted in Specificity.
Journal of virology.
2015
Academic Article
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Times cited: 121 -
Short Communication: Virion Aggregation by Neutralizing and Nonneutralizing Antibodies to the HIV-1 Envelope Glycoprotein.
AIDS research and human retroviruses.
2015
Academic Article
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Times cited: 12 -
HIV-1 VACCINES. HIV-1 neutralizing antibodies induced by native-like envelope trimers.
Science (New York, N.Y.).
2015
Academic Article
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Times cited: 421 -
Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice.
Cell.
2015
Academic Article
GET IT
Times cited: 213 -
Structural Constraints Determine the Glycosylation of HIV-1 Envelope Trimers.
Cell reports.
2015
Academic Article
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Times cited: 109 -
Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer.
PLoS pathogens.
2015
Academic Article
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Times cited: 85 -
What Do Chaotrope-Based Avidity Assays for Antibodies to HIV-1 Envelope Glycoproteins Measure?.
Journal of virology.
2015
Academic Article
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Times cited: 23 -
Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env.
Nature communications.
2015
Academic Article
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Times cited: 109 -
A native-like SOSIP.664 trimer based on an HIV-1 subtype B env gene.
Journal of virology.
2015
Academic Article
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Times cited: 199 -
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex.
Proceedings of the National Academy of Sciences of the United States of America.
2014
Academic Article
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Times cited: 280 -
HIV: A stamp on the envelope.
Nature.
2014
Article
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Times cited: 26 -
Structural evolution of glycan recognition by a family of potent HIV antibodies.
Cell.
2014
Academic Article
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Times cited: 147 -
Independent evolution of Fc- and Fab-mediated HIV-1-specific antiviral antibody activity following acute infection.
European journal of immunology.
2014
Academic Article
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Times cited: 44 -
Structure of 2G12 Fab2 in complex with soluble and fully glycosylated HIV-1 Env by negative-stain single-particle electron microscopy.
Journal of virology.
2014
Academic Article
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Times cited: 55 -
CD4-induced activation in a soluble HIV-1 Env trimer.
Structure (London, England : 1993).
2014
Academic Article
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Times cited: 102 -
Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits.
Retrovirology.
2014
Academic Article
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Times cited: 131 -
Stable 293Â T and CHO cell lines expressing cleaved, stable HIV-1 envelope glycoprotein trimers for structural and vaccine studies.
Retrovirology.
2014
Academic Article
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Times cited: 45 -
Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers.
Immunity.
2014
Academic Article
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Times cited: 307 -
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers.
Immunity.
2014
Academic Article
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Times cited: 282 -
Autoantibodies induced by chimeric cytokine-HIV envelope glycoprotein immunogens.
Journal of immunology (Baltimore, Md. : 1950).
2014
Academic Article
GET IT
Times cited: 3 -
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies.
Nature.
2014
Academic Article
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Times cited: 592 -
Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides.
Journal of pharmaceutical sciences.
2014
Academic Article
GET IT
Times cited: 16 -
Pharmacokinetics of a CCR5 inhibitor in rhesus macaques following vaginal, rectal and oral application.
The Journal of antimicrobial chemotherapy.
2013
Academic Article
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Times cited: 13 -
Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer.
Science (New York, N.Y.).
2013
Academic Article
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Times cited: 579 -
Crystal structure of a soluble cleaved HIV-1 envelope trimer.
Science (New York, N.Y.).
2013
Academic Article
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Times cited: 711 -
Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Academic Article
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Times cited: 154 -
A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies.
PLoS pathogens.
2013
Academic Article
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Times cited: 731 -
Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein.
Journal of virology.
2013
Academic Article
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Times cited: 76 -
Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers.
Journal of virology.
2013
Academic Article
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Times cited: 67 -
Comparative Immunogenicity of Evolved V1V2-Deleted HIV-1 Envelope Glycoprotein Trimers.
PloS one.
2013
Academic Article
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Times cited: 8 -
An HIV-1 envelope glycoprotein trimer with an embedded IL-21 domain activates human B cells.
PloS one.
2013
Academic Article
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Times cited: 5 -
Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120.
Nature structural & molecular biology.
2013
Academic Article
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Times cited: 287 -
Clinical adjuvant combinations stimulate potent B-cell responses in vitro by activating dermal dendritic cells.
PloS one.
2013
Academic Article
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Times cited: 14 -
Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.
PLoS pathogens.
2013
Academic Article
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Times cited: 249 -
Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants.
Journal of virology.
2013
Academic Article
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Times cited: 31 -
Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9.
Proceedings of the National Academy of Sciences of the United States of America.
2013
Academic Article
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Times cited: 214 -
Transmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5.
Journal of virology.
2012
Academic Article
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Times cited: 62 -
Potent induction of antibody-secreting B cells by human dermal-derived CD14+ dendritic cells triggered by dual TLR ligation.
Journal of immunology (Baltimore, Md. : 1950).
2012
Academic Article
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Times cited: 33 -
Pharmacokinetics and efficacy of a vaginally administered maraviroc gel in rhesus macaques.
The Journal of antimicrobial chemotherapy.
2012
Academic Article
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Times cited: 54 -
Partial protection against multiple RT-SHIV162P3 vaginal challenge of rhesus macaques by a silicone elastomer vaginal ring releasing the NNRTI MC1220.
The Journal of antimicrobial chemotherapy.
2012
Academic Article
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Times cited: 29 -
HIV-1 gp120 impairs the induction of B cell responses by TLR9-activated plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950).
2012
Academic Article
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Times cited: 25 -
Good CoP, bad CoP? Interrogating the immune responses to primate lentiviral vaccines.
Retrovirology.
2012
Information Resource
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Times cited: 12 -
Glycan-dependent immunogenicity of recombinant soluble trimeric hemagglutinin.
Journal of virology.
2012
Academic Article
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Times cited: 59 -
Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers.
The Journal of biological chemistry.
2012
Academic Article
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Times cited: 43 -
Macaque studies of vaccine and microbicide combinations for preventing HIV-1 sexual transmission.
Proceedings of the National Academy of Sciences of the United States of America.
2012
Academic Article
GET IT
Times cited: 39 -
Enhancement of α-helix mimicry by an α/β-peptide foldamer via incorporation of a dense ionic side-chain array.
Journal of the American Chemical Society.
2012
Academic Article
GET IT
Times cited: 60 -
Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance.
Virology.
2012
Academic Article
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Times cited: 15 -
V3 determinants of HIV-1 escape from the CCR5 inhibitors Maraviroc and Vicriviroc.
Virology.
2012
Academic Article
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Times cited: 31 -
HIV-1 Env antibodies: are we in a bind or going blind?.
Nature medicine.
2012
Article
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Times cited: 7 -
Sustained release of the CCR5 inhibitors CMPD167 and maraviroc from vaginal rings in rhesus macaques.
Antimicrobial agents and chemotherapy.
2012
Academic Article
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Times cited: 61 -
Differential use of CCR5 by HIV-1 clinical isolates resistant to small-molecule CCR5 antagonists.
Antimicrobial agents and chemotherapy.
2012
Academic Article
GET IT
Times cited: 8 -
Targeting HIV-1 envelope glycoprotein trimers to B cells by using APRIL improves antibody responses.
Journal of virology.
2011
Academic Article
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Times cited: 38 -
SHIV-162P3 infection of rhesus macaques given maraviroc gel vaginally does not involve resistant viruses.
PloS one.
2011
Academic Article
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Times cited: 13 -
Env-glycoprotein heterogeneity as a source of apparent synergy and enhanced cooperativity in inhibition of HIV-1 infection by neutralizing antibodies and entry inhibitors.
Virology.
2011
Academic Article
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Times cited: 18 -
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield.
Science (New York, N.Y.).
2011
Academic Article
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Times cited: 602 -
Non-aqueous silicone elastomer gels as a vaginal microbicide delivery system for the HIV-1 entry inhibitor maraviroc.
Journal of controlled release : official journal of the Controlled Release Society.
2011
Academic Article
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Times cited: 49 -
Occluding the mannose moieties on human immunodeficiency virus type 1 gp120 with griffithsin improves the antibody responses to both proteins in mice.
AIDS research and human retroviruses.
2011
Academic Article
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Times cited: 28 -
Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures.
Proceedings of the National Academy of Sciences of the United States of America.
2011
Academic Article
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Times cited: 137 -
A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells.
Retrovirology.
2011
Academic Article
GET IT
Times cited: 26 -
Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody.
Proceedings of the National Academy of Sciences of the United States of America.
2011
Academic Article
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Times cited: 226 -
Multiple CCR5 conformations on the cell surface are used differentially by human immunodeficiency viruses resistant or sensitive to CCR5 inhibitors.
Journal of virology.
2011
Academic Article
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Times cited: 54 -
How can HIV-type-1-Env immunogenicity be improved to facilitate antibody-based vaccine development?.
AIDS research and human retroviruses.
2011
Information Resource
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Times cited: 61 -
A chimeric HIV-1 envelope glycoprotein trimer with an embedded granulocyte-macrophage colony-stimulating factor (GM-CSF) domain induces enhanced antibody and T cell responses.
The Journal of biological chemistry.
2011
Academic Article
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Times cited: 15 -
Resistance of a human immunodeficiency virus type 1 isolate to a small molecule CCR5 inhibitor can involve sequence changes in both gp120 and gp41.
Virology.
2011
Academic Article
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Times cited: 21 -
Stabilized HIV-1 envelope glycoprotein trimers lacking the V1V2 domain, obtained by virus evolution.
The Journal of biological chemistry.
2010
Academic Article
GET IT
Times cited: 22 -
Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor.
The Journal of infectious diseases.
2010
Academic Article
GET IT
Times cited: 126 -
Misconduct: don't penalize the honest majority of scientists.
Nature.
2010
Article
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Times cited: 1 -
IgG subclass profiles in infected HIV type 1 controllers and chronic progressors and in uninfected recipients of Env vaccines.
AIDS research and human retroviruses.
2010
Academic Article
GET IT
Times cited: 96 -
Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function.
Virology.
2010
Academic Article
GET IT
Times cited: 64 -
Role of a putative gp41 dimerization domain in human immunodeficiency virus type 1 membrane fusion.
Journal of virology.
2010
Academic Article
GET IT
Times cited: 16 -
Adenovirus vectors block human immunodeficiency virus-1 replication in human alveolar macrophages by inhibition of the long terminal repeat.
American journal of respiratory cell and molecular biology.
2009
Academic Article
GET IT
Times cited: 4 -
Structural and biological mimicry of protein surface recognition by alpha/beta-peptide foldamers.
Proceedings of the National Academy of Sciences of the United States of America.
2009
Academic Article
GET IT
Times cited: 229 -
Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry.
PLoS pathogens.
2009
Academic Article
GET IT
Times cited: 62 -
Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1.
Vaccine.
2009
Academic Article
GET IT
Times cited: 54 -
Enzymatic removal of mannose moieties can increase the immune response to HIV-1 gp120 in vivo.
Virology.
2009
Academic Article
GET IT
Times cited: 45 -
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Immunological evidence for interactions between the first, second, and fifth conserved domains of the gp120 surface glycoprotein of human immunodeficiency virus type 1.
Journal of virology.
1994
Academic Article
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Times cited: 82 -
Intravaginal inoculation of rhesus macaques with cell-free simian immunodeficiency virus results in persistent or transient viremia.
Journal of virology.
1994
Academic Article
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Immunization with a soluble CD4-gp120 complex preferentially induces neutralizing anti-human immunodeficiency virus type 1 antibodies directed to conformation-dependent epitopes of gp120.
Journal of virology.
1994
Academic Article
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Times cited: 58 -
Development of the anti-gp120 antibody response during seroconversion to human immunodeficiency virus type 1.
Journal of virology.
1994
Academic Article
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Times cited: 189 -
Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1.
Journal of virology.
1994
Academic Article
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Times cited: 425 -
Epitope mapping and topology of baculovirus-expressed HIV-1 gp160 determined with a panel of murine monoclonal antibodies.
AIDS research and human retroviruses.
1994
Academic Article
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Times cited: 157 -
Studies with monoclonal antibodies to the V3 region of HIV-1 gp120 reveal limitations to the utility of solid-phase peptide binding assays.
Journal of acquired immune deficiency syndromes.
1994
Academic Article
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Times cited: 25 -
Characterization of mutants of human immunodeficiency virus type 1 that have escaped neutralization by a monoclonal antibody to the gp120 V2 loop.
Journal of virology.
1994
Academic Article
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Times cited: 24 -
Probing the structure of the human immunodeficiency virus surface glycoprotein gp120 with a panel of monoclonal antibodies.
Journal of virology.
1994
Academic Article
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Times cited: 241 -
Antigenic variation in gp120s from molecular clones of HIV-1 LAI.
AIDS research and human retroviruses.
1993
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Times cited: 32 -
Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding.
Journal of virology.
1993
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Times cited: 307 -
Detecting SIV gp120 and its interaction with soluble CD4 by ELISA.
AIDS research and human retroviruses.
1993
Academic Article
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Times cited: 6 -
Nonaffinity purification of recombinant gp120 for use in AIDS vaccine development.
AIDS research and human retroviruses.
1993
Academic Article
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Times cited: 42 -
The role of CD4 in HIV binding and entry.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
1993
Information Resource
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Times cited: 81 -
Towards a structure of the HIV-1 envelope glycoprotein gp120: an immunochemical approach.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
1993
Academic Article
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Times cited: 8 -
Probing the structure of the V2 domain of human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: human immune response to the V1 and V2 domains.
Journal of virology.
1993
Academic Article
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Times cited: 113 -
Immunochemical analysis of the gp120 surface glycoprotein of human immunodeficiency virus type 1: probing the structure of the C4 and V4 domains and the interaction of the C4 domain with the V3 loop.
Journal of virology.
1993
Academic Article
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Times cited: 136 -
A hidden region in the third variable domain of HIV-1 IIIB gp120 identified by a monoclonal antibody.
AIDS research and human retroviruses.
1993
Academic Article
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Times cited: 16 -
Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding.
Journal of virology.
1993
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Times cited: 579 -
Adaptation of two primary human immunodeficiency virus type 1 isolates to growth in transformed T cell lines correlates with alterations in the responses of their envelope glycoproteins to soluble CD4.
AIDS research and human retroviruses.
1993
Academic Article
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Times cited: 74 -
The reactivities of HIV-1+ human sera with solid-phase V3 loop peptides can be poor predictors of their reactivities with V3 loops on native gp120 molecules.
AIDS research and human retroviruses.
1993
Academic Article
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Times cited: 33 -
Antibodies to discontinuous or conformationally sensitive epitopes on the gp120 glycoprotein of human immunodeficiency virus type 1 are highly prevalent in sera of infected humans.
Journal of virology.
1993
Academic Article
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Times cited: 208 -
Effect of mutations in the V3 loop of HIV-1 gp120 on infectivity and susceptibility to proteolytic cleavage.
AIDS research and human retroviruses.
1993
Academic Article
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Times cited: 33 -
Identification of human immunodeficiency virus type 1 glycoprotein gp120/gp41 interacting sites by the idiotypic mimicry of two monoclonal antibodies.
AIDS research and human retroviruses.
1993
Academic Article
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Times cited: 27 -
Conserved structural features in the interaction between retroviral surface and transmembrane glycoproteins?.
AIDS research and human retroviruses.
1992
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Times cited: 80 -
HIV-negative AIDS.
Lancet (London, England).
1992
Conference Paper
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A monoclonal antibody to CD4 domain 2 blocks soluble CD4-induced conformational changes in the envelope glycoproteins of human immunodeficiency virus type 1 (HIV-1) and HIV-1 infection of CD4+ cells.
Journal of virology.
1992
Academic Article
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Times cited: 127 -
Antigenicity of the HIV-2 V3 loop.
AIDS (London, England).
1992
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Complementation of human immunodeficiency virus glycoprotein mutations in trans.
The Journal of general virology.
1992
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Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus.
Virology.
1992
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CPF-DD is an inhibitor of infection by human immunodeficiency virus and other enveloped viruses in vitro.
Virology.
1992
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Monoclonal antibodies to the C4 region of human immunodeficiency virus type 1 gp120: use in topological analysis of a CD4 binding site.
AIDS research and human retroviruses.
1992
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Times cited: 28 -
Thermodynamic and kinetic analysis of sCD4 binding to HIV-1 virions and of gp120 dissociation.
AIDS research and human retroviruses.
1992
Academic Article
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Times cited: 43 -
Kinetics of the HIV-CD4 interactions and virus-cell fusion.
AIDS (London, England).
1992
Editorial Article
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Times cited: 7 -
Investigations into the mechanism by which sulfated polysaccharides inhibit HIV infection in vitro.
AIDS research and human retroviruses.
1992
Academic Article
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Times cited: 166 - Twin-Site ELISAs for fos and myc Oncoproteins Using the AMPAK System. Methods in molecular biology (Clifton, N.J.). 1992 Academic Article GET IT
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Virions of primary human immunodeficiency virus type 1 isolates resistant to soluble CD4 (sCD4) neutralization differ in sCD4 binding and glycoprotein gp120 retention from sCD4-sensitive isolates.
Journal of virology.
1992
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Times cited: 286 -
Rat monoclonal antibodies to nonoverlapping epitopes of human immunodeficiency virus type 1 gp120 block CD4 binding in vitro.
Virology.
1991
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Times cited: 42 -
Conformational changes induced in the human immunodeficiency virus envelope glycoprotein by soluble CD4 binding.
The Journal of experimental medicine.
1991
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c-myc protein expression in untransformed fibroblasts.
Oncogene.
1991
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Times cited: 139 -
Direct measurement of soluble CD4 binding to human immunodeficiency virus type 1 virions: gp120 dissociation and its implications for virus-cell binding and fusion reactions and their neutralization by soluble CD4.
Journal of virology.
1991
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Times cited: 162 -
HIV infectivity.
Nature.
1991
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Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization.
Journal of virology.
1991
Academic Article
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Times cited: 212 -
Reduction in CD4 binding affinity associated with removal of a single glycosylation site in the external glycoprotein of HIV-2.
Virology.
1991
Academic Article
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Times cited: 22 -
Differential c-myc protein expression in Burkitt's lymphomas and EBV-transformed lymphoblastoid lines.
European journal of cancer.
1991
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Times cited: 7 -
Induction of high-titer neutralizing antibodies, using hybrid human immunodeficiency virus V3-Ty viruslike particles in a clinically relevant adjuvant.
Journal of virology.
1991
Academic Article
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Times cited: 52 -
The V3 loops of the HIV-1 and HIV-2 surface glycoproteins contain proteolytic cleavage sites: a possible function in viral fusion?.
AIDS research and human retroviruses.
1991
Academic Article
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Times cited: 198 -
The role of the V3 loop of gp120 in HIV infection.
AIDS (London, England).
1991
Information Resource
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Times cited: 135 -
Dissociation of gp120 from HIV-1 virions induced by soluble CD4.
Science (New York, N.Y.).
1990
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Times cited: 455 -
Enhancement of soluble CD4-mediated HIV neutralization and gp 120 binding by CD4 autoantibodies and monoclonal antibodies.
AIDS research and human retroviruses.
1990
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Times cited: 17 -
GTP gamma S inhibits early c-myc protein accumulation but not DNA synthesis in Swiss 3T3 fibroblasts.
FEBS letters.
1990
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Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.
The Journal of experimental medicine.
1990
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HIV-1 envelope protein gp120 expression by secretion in E. coli: assessment of CD4 binding and use in epitope mapping.
Journal of virological methods.
1990
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Times cited: 16 -
Expression of HIV-1 gp120 and human soluble CD4 by recombinant baculoviruses and their interaction in vitro.
AIDS research and human retroviruses.
1990
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Times cited: 47 -
Characterization of recombinant gp120 and gp160 from HIV-1: binding to monoclonal antibodies and soluble CD4.
AIDS (London, England).
1990
Academic Article
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Times cited: 101 -
Simple methods for monitoring HIV-1 and HIV-2 gp120 binding to soluble CD4 by enzyme-linked immunosorbent assay: HIV-2 has a 25-fold lower affinity than HIV-1 for soluble CD4.
AIDS (London, England).
1990
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Protein kinase C-induced stimulation or inhibition of cellular proliferation in a murine macrophage tumor cell line.
Cancer research.
1990
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Times cited: 4 - Selection and preliminary characterization of variant lines of a murine macrophage tumor resistant to the antiproliferative effects of phorbol esters. Cancer research. 1990 Academic Article GET IT
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Mitogen-stimulated activation of the Na+/H+ antiporter does not regulate S6 phosphorylation or protein synthesis in murine thymocytes or Swiss 3T3 fibroblasts.
The Journal of biological chemistry.
1990
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Times cited: 6 -
Induction of c-fos protein by activation of vasopressin receptors in smooth muscle cells.
FEBS letters.
1989
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Times cited: 13 -
An enzyme-linked immunosorbent assay for antibodies to the envelope glycoproteins of divergent strains of HIV-1.
AIDS (London, England).
1989
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Dissociation of c-fos induction from protein kinase C-independent mitogenesis in Swiss 3T3 cells.
Oncogene research.
1989
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Times cited: 9 -
Sensitive ELISA for the gp120 and gp160 surface glycoproteins of HIV-1.
AIDS research and human retroviruses.
1988
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Times cited: 61 -
Ca2+ and pH responses to sequential additions of mitogens in single 3T3 fibroblasts: correlations with DNA synthesis.
The Journal of biological chemistry.
1988
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C-fos gene activation in murine thymocytes by a mechanism independent of protein kinase C or a Ca2+ signal.
FEBS letters.
1988
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A sensitive enzyme-linked immunosorbence assay for the c-fos and v-fos oncoproteins.
Biochimica et biophysica acta.
1988
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Differential induction of c-fos and c-myc by cyclic AMP in Swiss 3T3 cells: significance for the mitogenic response.
Oncogene research.
1988
Academic Article
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Times cited: 18 -
Immunological probes in the analysis of myc protein expression.
Current topics in microbiology and immunology.
1988
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Times cited: 10 -
Synergistic signals in the mechanism of antigen-induced exocytosis in 2H3 cells: evidence for an unidentified signal required for histamine release.
The Journal of cell biology.
1987
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Times cited: 84 -
Extraction and recovery of inositol phosphates from tissues.
The Biochemical journal.
1987
Article
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Calcium regulates inositol 1,3,4,5-tetrakisphosphate production in lysed thymocytes and in intact cells stimulated with concanavalin A.
The EMBO journal.
1987
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Times cited: 36 -
The early mitogenic pathway in mouse thymocytes: an analysis of the dual signal hypothesis.
Advances in experimental medicine and biology.
1987
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c-fos and c-myc gene activation, ionic signals, and DNA synthesis in thymocytes.
The Journal of biological chemistry.
1986
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Times cited: 66 -
A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells.
Nature.
1985
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Mitogens increase phosphorylation of phosphoinositides in thymocytes.
Nature.
1984
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Times cited: 129 - Calcium signals and phospholipid methylation in eukaryotic cells. The Biochemical journal. 1984 Academic Article GET IT
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The calcium signal and phosphatidylinositol breakdown in 2H3 cells.
The Journal of biological chemistry.
1984
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The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.
The Journal of biological chemistry.
1984
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Times cited: 263 -
Large effects of preparative techniques on lymphocyte cyclic AMP content.
The Biochemical journal.
1983
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Times cited: 10 -
The bivalent-cation dependence of phosphatidylinositol synthesis in a cell-free system from lymphocytes.
The Biochemical journal.
1983
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Times cited: 4 -
Free cytoplasmic calcium concentration and the mitogenic stimulation of lymphocytes.
The Journal of biological chemistry.
1983
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Times cited: 322 -
Early increases in phospholipid methylation are not necessary for the mitogenic stimulation of lymphocytes.
The Journal of biological chemistry.
1982
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Times cited: 20