Santambrogio, Laura

Publications

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selected publications

Longitudinal analysis of the gut microbiota during anti-PD-1 therapy reveals stable microbial features of response in melanoma patients. Cell host & microbe. 2024 Academic Article GET IT
Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load. Cell reports. 2024 Academic Article GET IT
Non-mutational neoantigens in disease. Nature immunology. 2024 Review GET IT
Molecular determinants of the crosstalk between endosomal microautophagy and chaperone-mediated autophagy. Cell reports. 2023 Academic Article GET IT
Updates on radiotherapy-immunotherapy combinations: Proceedings of 6^th annual ImmunoRad conference. Oncoimmunology. 2023 Review GET IT
Times cited: 2
Autoimmunity to the modified self. Science (New York, N.Y.). 2023 Academic Article GET IT
PDIA3 epitope-driven immune autoreactivity contributes to hepatic damage in type 2 diabetes. Science immunology. 2022 Academic Article GET IT
Molecular Determinants Regulating the Plasticity of the MHC Class II Immunopeptidome. Frontiers in immunology. 2022 Review GET IT
Lung lymphatic thrombosis and dysfunction caused by cigarette smoke exposure precedes emphysema in mice. Scientific reports. 2022 Academic Article GET IT
Advances in understanding and examining lymphatic function: relevance for understanding autoimmunity. Current opinion in rheumatology. 2021 Information Resource GET IT
Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer. Nature reviews. Clinical oncology. 2021 Review GET IT
Autophagy in major human diseases. The EMBO journal. 2021 Review GET IT
Times cited: 846
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine. Nature communications. 2021 Academic Article GET IT
A protocol for qualitative and quantitative measurement of endosomal processing using hot spot analysis. STAR protocols. 2021 Academic Article GET IT
Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection. Nature communications. 2021 Academic Article GET IT
Distinguishing Signal From Noise in Immunopeptidome Studies of Limiting-Abundance Biological Samples: Peptides Presented by I-A^b in C57BL/6 Mouse Thymus. Frontiers in immunology. 2021 Academic Article GET IT
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome. Cell. 2021 Academic Article GET IT
Times cited: 187
Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery. Immunity. 2021 Academic Article GET IT
Times cited: 34
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control. The Journal of clinical investigation. 2021 Academic Article GET IT
Times cited: 141
Class IA PI3Ks regulate subcellular and functional dynamics of IDO1. EMBO reports. 2020 Academic Article GET IT
Times cited: 24
In vivo T1 mapping for quantifying glymphatic system transport and cervical lymph node drainage. Scientific reports. 2020 Academic Article GET IT
Times cited: 31
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America. 2020 Academic Article GET IT
Times cited: 60
Lymphatic remodelling in response to lymphatic injury in the hind limbs of sheep. Nature biomedical engineering. 2019 Academic Article GET IT
Times cited: 8
Lymphatic Cannulation for Lymph Sampling and Molecular Delivery. Journal of immunology (Baltimore, Md. : 1950). 2019 Academic Article GET IT
Times cited: 17
Parabiosis Incompletely Reverses Aging-Induced Metabolic Changes and Oxidant Stress in Mouse Red Blood Cells. Nutrients. 2019 Academic Article GET IT
Times cited: 23
The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells. Frontiers in immunology. 2019 Information Resource GET IT
Times cited: 49
The negative effect of lipid challenge on autophagy inhibits T cell responses. Autophagy. 2019 Academic Article GET IT
Times cited: 21
Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients. The Journal of experimental medicine. 2019 Academic Article GET IT
Times cited: 97
Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF ^V600E mutation. The Journal of experimental medicine. 2019 Academic Article GET IT
Times cited: 97
Senescence cell-associated extracellular vesicles serve as osteoarthritis disease and therapeutic markers. JCI insight. 2019 Academic Article GET IT
Times cited: 121
Message in a vesicle - trans-kingdom intercommunication at the vector-host interface. Journal of cell science. 2019 Information Resource GET IT
Times cited: 13
In vitro model reveals a role for mechanical stretch in the remodeling response of lymphatic muscle cells. Microcirculation (New York, N.Y. : 1994). 2018 Academic Article GET IT
Times cited: 5
Contribution of the plasma and lymph Degradome and Peptidome to the MHC Ligandome. Immunogenetics. 2018 Information Resource GET IT
Times cited: 14
Quantitative Profiling of the Lymph Node Clearance Capacity. Scientific reports. 2018 Academic Article GET IT
Times cited: 34
Pancreatic islets communicate with lymphoid tissues via exocytosis of insulin peptides. Nature. 2018 Academic Article GET IT
Times cited: 84
The Lymphatic Fluid. International review of cell and molecular biology. 2018 Article GET IT
Times cited: 7
NLRP10 Enhances CD4⁺ T-Cell-Mediated IFNγ Response via Regulation of Dendritic Cell-Derived IL-12 Release. Frontiers in immunology. 2017 Academic Article GET IT
Times cited: 19
Molecular definitions of autophagy and related processes. The EMBO journal. 2017 Information Resource GET IT
Times cited: 1255
A Relay Pathway between Arginine and Tryptophan Metabolism Confers Immunosuppressive Properties on Dendritic Cells. Immunity. 2017 Academic Article GET IT
Times cited: 243
Whole Chromosome Instability induces senescence and promotes SASP. Scientific reports. 2016 Academic Article GET IT
Times cited: 112
Structural and Biological Interaction of hsc-70 Protein with Phosphatidylserine in Endosomal Microautophagy. The Journal of biological chemistry. 2016 Academic Article GET IT
Times cited: 49
The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation. Infection and immunity. 2016 Academic Article GET IT
Times cited: 36
Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in vivo. Blood. 2016 Academic Article GET IT
Times cited: 77
The melting pot of the MHC II peptidome. Current opinion in immunology. 2016 Information Resource GET IT
Times cited: 32
Autoimmune response to transthyretin in juvenile idiopathic arthritis. JCI insight. 2016 Academic Article GET IT
Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels. Cell reports. 2016 Academic Article GET IT
Times cited: 88
Role of Carbonyl Modifications on Aging-Associated Protein Aggregation. Scientific reports. 2016 Academic Article GET IT
Times cited: 86
Kupffer Cell Transplantation in Mice for Elucidating Monocyte/Macrophage Biology and for Potential in Cell or Gene Therapy. The American journal of pathology. 2016 Academic Article GET IT
Times cited: 29
Differential gene expression in human, murine, and cell line-derived macrophages upon polarization. Experimental cell research. 2015 Academic Article GET IT
Times cited: 77
Consequences of metabolic and oxidative modifications of cartilage tissue. Nature reviews. Rheumatology. 2015 Information Resource GET IT
Times cited: 45
Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance. Aging cell. 2015 Academic Article GET IT
Times cited: 103
Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging. Aging cell. 2015 Academic Article GET IT
Times cited: 143
Annexin A2 promotes phagophore assembly by enhancing Atg16L⁺ vesicle biogenesis and homotypic fusion. Nature communications. 2015 Academic Article GET IT
Times cited: 36
Hydrodynamic size-based separation and characterization of protein aggregates from total cell lysates. Nature protocols. 2014 Academic Article GET IT
Times cited: 6
Molecular analysis of chromium and cobalt-related toxicity. Scientific reports. 2014 Academic Article GET IT
Times cited: 170
Carrying yourself: self antigen composition of the lymphatic fluid. Lymphatic research and biology. 2013 Academic Article GET IT
Times cited: 5
Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage. Blood. 2013 Academic Article GET IT
Times cited: 55
Age-related carbonylation of fibrocartilage structural proteins drives tissue degenerative modification. Chemistry & biology. 2013 Academic Article GET IT
Times cited: 47
Disruption of multivesicular body vesicles does not affect major histocompatibility complex (MHC) class II-peptide complex formation and antigen presentation by dendritic cells. The Journal of biological chemistry. 2013 Academic Article GET IT
Times cited: 10
The lipid kinase PI4KIIIβ preserves lysosomal identity. The EMBO journal. 2012 Academic Article GET IT
Times cited: 101
Protein expression profiles of human lymph and plasma mapped by 2D-DIGE and 1D SDS-PAGE coupled with nanoLC-ESI-MS/MS bottom-up proteomics. Journal of proteomics. 2012 Academic Article GET IT
Times cited: 62
The annexin A2/S100A10 system in health and disease: emerging paradigms. Journal of biomedicine & biotechnology. 2012 Information Resource GET IT
Times cited: 82
Orthopedic wear debris mediated inflammatory osteolysis is mediated in part by NALP3 inflammasome activation. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2012 Academic Article GET IT
Times cited: 74
Age-related oxidative stress compromises endosomal proteostasis. Cell reports. 2012 Academic Article GET IT
Times cited: 78
Guidelines for the use and interpretation of assays for monitoring autophagy. 2012 GET IT
Times cited: 2762
Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris. Nature communications. 2012 Academic Article GET IT
Times cited: 46
Mediators of the inflammatory response to joint replacement devices. Nature reviews. Rheumatology. 2011 Information Resource GET IT
Times cited: 106
Oxidative stress, inflamm-aging and immunosenescence. Journal of proteomics. 2011 Information Resource GET IT
Times cited: 196
Chasing the elusive mammalian microautophagy. Autophagy. 2011 Academic Article GET IT
Microautophagy of cytosolic proteins by late endosomes. Developmental cell. 2011 Academic Article GET IT
Times cited: 694
The lymph as a pool of self-antigens. Trends in immunology. 2010 Article GET IT
Times cited: 60
Dendritic cell-mediated in vivo bone resorption. Journal of immunology (Baltimore, Md. : 1950). 2010 Academic Article GET IT
Times cited: 38
An expanded self-antigen peptidome is carried by the human lymph as compared to the plasma. PloS one. 2010 Academic Article GET IT
Times cited: 57
Short communication: Methamphetamine treatment increases in vitro and in vivo HIV replication. AIDS research and human retroviruses. 2009 Academic Article GET IT
Times cited: 51
A mutation within the transmembrane domain of melanosomal protein Silver (Pmel17) changes lumenal fragment interactions. European journal of cell biology. 2009 Academic Article GET IT
Times cited: 8
Methamphetamine enhances histoplasmosis by immunosuppression of the host. The Journal of infectious diseases. 2009 Academic Article GET IT
Times cited: 53
Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages. Infection and immunity. 2009 Academic Article GET IT
Times cited: 67
Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1. The American journal of pathology. 2008 Academic Article GET IT
Times cited: 90
Functional analysis of monocyte MHC class II compartments. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008 Academic Article GET IT
Times cited: 15
Immunogenecity of modified alkane polymers is mediated through TLR1/2 activation. PloS one. 2008 Academic Article GET IT
Times cited: 48
A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate of the fungus in murine macrophages. Eukaryotic cell. 2008 Academic Article GET IT
Times cited: 34
Methamphetamine inhibits antigen processing, presentation, and phagocytosis. PLoS pathogens. 2008 Academic Article GET IT
Times cited: 122
GMCSF in the absence of other cytokines sustains human dendritic cell precursors with T cell regulatory activity and capacity to differentiate into functional dendritic cells. Immunology letters. 2007 Academic Article GET IT
Times cited: 31
Immune responses to lentiviral vectors. Current gene therapy. 2007 Information Resource GET IT
Times cited: 74
CD4-specific transgenic expression of human cyclin T1 markedly increases human immunodeficiency virus type 1 (HIV-1) production by CD4+ T lymphocytes and myeloid cells in mice transgenic for a provirus encoding a monocyte-tropic HIV-1 isolate. Journal of virology. 2006 Academic Article GET IT
Times cited: 32
MHC class II compartment subtypes: structure and function. Current opinion in immunology. 2005 Information Resource GET IT
Times cited: 48
Copolymer effects on microglia and T cells in the central nervous system of humanized mice. European journal of immunology. 2005 Academic Article GET IT
Times cited: 15
Conformational variation of surface class II MHC proteins during myeloid dendritic cell differentiation accompanies structural changes in lysosomal MIIC. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 29
Involvement of caspase-cleaved and intact adaptor protein 1 complex in endosomal remodeling in maturing dendritic cells. Nature immunology. 2005 Academic Article GET IT
Times cited: 64
Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism. Journal of immunology (Baltimore, Md. : 1950). 2005 Academic Article GET IT
Times cited: 235
Caspases and nitric oxide broadly regulate dendritic cell maturation and surface expression of class II MHC proteins. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 41
Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 46
Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 37
Monoclonal antibodies specific for the empty conformation of HLA-DR1 reveal aspects of the conformational change associated with peptide binding. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 45
The scavenger receptor MARCO mediates cytoskeleton rearrangements in dendritic cells and microglia. Blood. 2003 Academic Article GET IT
Times cited: 84
Molecular interaction and enzymatic activity of macrophage migration inhibitory factor with immunorelevant peptides. The Journal of biological chemistry. 2003 Academic Article GET IT
Times cited: 31
Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 87
Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis. The Journal of clinical investigation. 2002 Academic Article GET IT
Times cited: 40
IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression. Journal of immunology (Baltimore, Md. : 1950). 2002 Academic Article GET IT
Times cited: 63
Ligand exchange of major histocompatibility complex class II proteins is triggered by H-bond donor groups of small molecules. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 38
RANTES-induced chemokine cascade in dendritic cells. Journal of immunology (Baltimore, Md. : 1950). 2001 Academic Article GET IT
Times cited: 64
Developmental plasticity of CNS microglia. Proceedings of the National Academy of Sciences of the United States of America. 2001 Academic Article GET IT
Times cited: 262
Modulation of experimental autoimmune encephalomyelitis: effect of altered peptide ligand on chemokine and chemokine receptor expression. Journal of neuroimmunology. 2000 Academic Article GET IT
Times cited: 81
Induction and suppression of an autoimmune disease by oligomerized T cell epitopes: enhanced in vivo potency of encephalitogenic peptides. The Journal of experimental medicine. 2000 Academic Article GET IT
Times cited: 44
Abundant empty class II MHC molecules on the surface of immature dendritic cells. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 137
Extracellular antigen processing and presentation by immature dendritic cells. Proceedings of the National Academy of Sciences of the United States of America. 1999 Academic Article GET IT
Times cited: 174
Antigen presenting capacity of brain microvasculature in altered peptide ligand modulation of experimental allergic encephalomyelitis. Journal of neuroimmunology. 1999 Academic Article GET IT
Times cited: 9
Altered peptide ligand modulation of experimental allergic encephalomyelitis: immune responses within the CNS. Journal of neuroimmunology. 1998 Academic Article GET IT
Times cited: 34
Staphylococcal enterotoxin B and tumor-necrosis factor-alpha-induced relapses of experimental allergic encephalomyelitis: protection by transforming growth factor-beta and interleukin-10. European journal of immunology. 1995 Academic Article GET IT
Times cited: 95
Tolerogenic forms of auto-antigens and cytokines in the induction of resistance to experimental allergic encephalomyelitis. Journal of neuroimmunology. 1995 Academic Article GET IT
Times cited: 40
Nerve growth factor production by lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 1994 Academic Article GET IT
Times cited: 186
Human leucocyte-endothelial interactions in peripheral arterial occlusive disease. European journal of clinical investigation. 1994 Academic Article GET IT
Times cited: 22
Antagonistic effects of endogenous and exogenous TGF-beta and TNF on auto-immune diseases in mice. Immunopharmacology and immunotoxicology. 1993 Academic Article GET IT
Times cited: 28
Studies on the mechanisms by which transforming growth factor-beta (TGF-beta) protects against allergic encephalomyelitis. Antagonism between TGF-beta and tumor necrosis factor. Journal of immunology (Baltimore, Md. : 1950). 1993 Academic Article GET IT
Times cited: 158
Dopamine receptors on human T- and B-lymphocytes. Journal of neuroimmunology. 1993 Academic Article GET IT
Times cited: 100
Leucocytes and free radicals in stable angina pectoris. Japanese heart journal. 1992 Academic Article GET IT
Times cited: 13
The influence of cinnoxicam on the immune system and renal function in aged patients with degenerative osteoarthrosis. Rivista Italiana di Biologia e Medicina. 1991 Article
Free radical production in peripheral vascular disease. A risk for critical ischaemia?. International angiology : a journal of the International Union of Angiology. 1991 Academic Article GET IT
Times cited: 11
Plasma profiles of adrenocorticotropic hormone, cortisol, growth hormone and prolactin in patients with untreated Parkinson's disease. Journal of neurology. 1991 Academic Article GET IT
Times cited: 65
Use of pentoxifylline as an inhibitor of free radical generation in peripheral vascular disease. Results of a double-blind placebo-controlled study. European journal of clinical pharmacology. 1991 Academic Article GET IT
Times cited: 54
A technique for detecting leukocyte-derived free radical production. Haematologica. 1990 Article GET IT
Effect of physical training on leukocyte rheology throughout induced ischaemia. International angiology : a journal of the International Union of Angiology. 1990 Academic Article GET IT
Times cited: 2
Vascular uptake of 111-In-platelets and of 123-I-LDL. Progress in clinical and biological research. 1990 Academic Article GET IT
Times cited: 2
Leucocyte behaviour in controlled ischaemia of the calves. Journal of clinical pathology. 1989 Academic Article GET IT
Times cited: 14
Rheological behavior of white blood cells. Stroke. 1989 Article GET IT
Times cited: 1
Cellular rheology in rheumatoid arthritis. Revista Portuguesa de Hemorreologia. 1989 Article
Effects of ticlopidine on haemorheological factors in rheumatoid arthritis: A double-blind study. Biorheology. 1989 Article
Impaired neurogenic microvascular response in patients with dysautonomia. Advances in Vascular Pathology 1989 vol. 2: proceedings of the 15th world congress of the International Union of Angiology. ICS868. 1989 Article
The influence of mepartricin on plasma lipids: preliminary data. Giornale di Gerontologia. 1989 Article
Effects of calcium antagonists and beta-adrenergic receptor blocking agents on cardiovascular rhythmicity. Panminerva medica. 1988 Academic Article GET IT
Risk factors for ischaemic brain infarction. BMJ (Clinical research ed.). 1988 Article GET IT
Times cited: 1

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Research

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Funding awarded

Biochemical and functional characterization of a novel anti-inflammatory biogenic amine awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2023 - 2028
Deciphering the individual contributions of the tumor microenvironment and cancer cells to the establishment of anti-tumor immunity in response to radiotherapy and immune checkpoint inhibitors Principal Investigator 2024 - 2025
Biochemical and Functional Analysis of CSF and lymph following changes in brain fluid dynamics. awarded by Cure Alzheimer’s Fund Principal Investigator 2022 - 2025
Effects of Glycation and Carbonylation on MHC II-restricted immunity awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2020 - 2025
DYNAMICS AND TUNING OF THE MHC II PRESENTED PEPTIDOME awarded by National Institute of Allergy & Infectious Diseases Principal Investigator 2019 - 2025

Mobilizing TAP-Independent CD8 T cells Through Non-Canonical Cross-Presentation awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2023 - 2027
The effects of immunosuppression on SARS-CoV-2 persistence, virus genetic diversity and clinical outcomes of COVID-19 awarded by National Institute of Allergy & Infectious Diseases Co-Investigator 2024 - 2026
Immunogenomic determinants of ethnic disparities in clinical outcomes for urothelial cancer patients awarded by National Human Genome Research Institute Co-Investigator 2020 - 2024

Dynamics of Immune Response in Irradiated Rectal Cancer awarded by National Cancer Institute Co-Principal Investigator 2022 - 2027
The effects of radiotherapy on the presentation of phosphorylated antigens by cancer cells awarded by Starr Cancer Consortium Co-Principal Investigator 2021 - 2024

Creating a 3D TNBC model of PTEN deficiency to discover immunoregulatory tumor epitopes awarded by National Institute on Aging Key Personnel 2023 - 2025

Langerhans cells and lymphatic regulation in immunity awarded by National Inst of Arthritis & Musculoskeletal & Skin Diseases Principal Investigator Subaward 2024 - 2029
Lymphatic drainage dysfunction in chronic hypertension awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2024 - 2028
Lymphatics-Glymphatics in CNS Fluid Homeostasis awarded by National Heart, Lung, & Blood Institute Principal Investigator Subaward 2021 - 2026
Understanding the biological mechanisms of lupus disease awarded by National Inst of Arthritis & Musculoskeletal & Skin Diseases Principal Investigator Subaward 2022 - 2025
Functional Consequences of Impaired Autophagy in Aging - P01AG031782 awarded by National Institute of Allergy & Infectious Diseases Principal Investigator Subaward 2020 - 2025
missing activity Principal Investigator Subaward 2022 - 2024

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Contact

full name

Laura Santambrogio

primary email

las4011@med.cornell.edu

VIVO Weill Cornell Medical College

Laura Santambrogio Professor of Radiation Oncology

Publications

selected publications

Research

Funding awarded

Contact

full name

primary email