Hempstead, Barbara L.

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selected publications

Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation. Frontiers in molecular neuroscience. 2023 Academic Article GET IT
Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor. The Journal of clinical investigation. 2022 Academic Article GET IT
Zinc induced structural changes in the intrinsically disordered BDNF Met prodomain confer synaptic elimination. Metallomics : integrated biometal science. 2020 Academic Article GET IT
Times cited: 1
SorCS2 is required for social memory and trafficking of the NMDA receptor. Molecular psychiatry. 2020 Academic Article GET IT
Times cited: 3
BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury. Frontiers in physiology. 2019 Information Resource GET IT
Times cited: 44
New Roles for an Ancient Factor. Trends in neurosciences. 2018 Article GET IT
The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron. 2018 Academic Article GET IT
Times cited: 39
A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75^NTR-Sortilin Receptor Complex and Attenuates proNGF-Induced Neuronal Death In Vitro and In Vivo. eNeuro. 2018 Academic Article GET IT
Times cited: 16
Effect of Early-Life Fluoxetine on Anxiety-Like Behaviors in BDNF Val66Met Mice. The American journal of psychiatry. 2017 Academic Article GET IT
Times cited: 20
Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2017 Academic Article GET IT
Times cited: 15
SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease. JCI insight. 2017 Academic Article GET IT
Times cited: 20
Autocrine BDNF-TrkB signalling within a single dendritic spine. Nature. 2016 Academic Article GET IT
Times cited: 226
Rapid Increases in proBDNF after Pilocarpine-Induced Status Epilepticus in Mice Are Associated with Reduced proBDNF Cleavage Machinery. eNeuro. 2016 Academic Article GET IT
Times cited: 36
Detection of p75NTR Trimers: Implications for Receptor Stoichiometry and Activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 Academic Article GET IT
Times cited: 35
Selective reduction of striatal mature BDNF without induction of proBDNF in the zQ175 mouse model of Huntington's disease. Neurobiology of disease. 2015 Academic Article GET IT
Times cited: 25
Slitrk5 Mediates BDNF-Dependent TrkB Receptor Trafficking and Signaling. Developmental cell. 2015 Academic Article GET IT
Times cited: 68
3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways. Biomaterials. 2015 Academic Article GET IT
Times cited: 105
Effects of the BDNF Val66Met Polymorphism on Anxiety-Like Behavior Following Nicotine Withdrawal in Mice. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2015 Academic Article GET IT
Times cited: 12
Brain-Derived Neurotrophic Factor: Three Ligands, Many Actions. Transactions of the American Clinical and Climatological Association. 2015 Information Resource GET IT
Times cited: 163
p75NTR, but not proNGF, is upregulated following status epilepticus in mice. ASN neuro. 2014 Academic Article GET IT
Times cited: 35
Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Academic Article GET IT
Times cited: 152
proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus. Cell reports. 2014 Academic Article GET IT
Times cited: 222
Mir-592 regulates the induction and cell death-promoting activity of p75NTR in neuronal ischemic injury. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Academic Article GET IT
Times cited: 81
Trkb signaling in pericytes is required for cardiac microvessel stabilization. PloS one. 2014 Academic Article GET IT
Times cited: 39
Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 2013 Academic Article GET IT
Times cited: 1766
Sympathetic denervation of peri-infarct myocardium requires the p75 neurotrophin receptor. Experimental neurology. 2013 Academic Article GET IT
Times cited: 30
Formation of microvascular networks in vitro. Nature protocols. 2013 Academic Article GET IT
Times cited: 126
ProBDNF and mature BDNF as punishment and reward signals for synapse elimination at mouse neuromuscular junctions. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013 Academic Article GET IT
Times cited: 87
BDNF protects human vascular endothelial cells from TNFα-induced apoptosis. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2013 Academic Article GET IT
Times cited: 25
A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific reports. 2013 Academic Article GET IT
Times cited: 129
Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction. Nature communications. 2013 Academic Article GET IT
Times cited: 172
ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation. The Journal of experimental medicine. 2012 Academic Article GET IT
Times cited: 63
Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 131
Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF. Journal of neurochemistry. 2012 Academic Article GET IT
Times cited: 17
In vitro microvessels for the study of angiogenesis and thrombosis. Proceedings of the National Academy of Sciences of the United States of America. 2012 Academic Article GET IT
Times cited: 723
Motoneuron programmed cell death in response to proBDNF. Developmental neurobiology. 2012 Academic Article GET IT
Times cited: 40
Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. Science signaling. 2011 Academic Article GET IT
Times cited: 133
Neuronal brain-derived neurotrophic factor is synthesized in excess, with levels regulated by sortilin-mediated trafficking and lysosomal degradation. The Journal of biological chemistry. 2011 Academic Article GET IT
Times cited: 87
Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 Academic Article GET IT
Times cited: 109
ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Academic Article GET IT
Times cited: 87
Understanding proneurotrophin actions: Recent advances and challenges. Developmental neurobiology. 2010 Information Resource GET IT
Times cited: 151
Molecular and structural insight into proNGF engagement of p75NTR and sortilin. Journal of molecular biology. 2009 Academic Article GET IT
Times cited: 92
Pro-BDNF-induced synaptic depression and retraction at developing neuromuscular synapses. The Journal of cell biology. 2009 Academic Article GET IT
Times cited: 116
NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death. The EMBO journal. 2009 Academic Article GET IT
Times cited: 41
Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development. Neuroscience. 2009 Review GET IT
Times cited: 121
Quantitative intact specimen magnetic resonance microscopy at 3.0 T. Magnetic resonance imaging. 2009 Academic Article GET IT
Times cited: 6
Control of extracellular cleavage of ProBDNF by high frequency neuronal activity. Proceedings of the National Academy of Sciences of the United States of America. 2009 Academic Article GET IT
Times cited: 211
Neuronal release of proBDNF. Nature neuroscience. 2009 Academic Article GET IT
Times cited: 357
Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 130
Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Academic Article GET IT
Times cited: 137
Neurotrophins and their receptors stimulate melanoma cell proliferation and migration. The Journal of investigative dermatology. 2008 Academic Article GET IT
Times cited: 118
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nature neuroscience. 2007 Academic Article GET IT
Times cited: 217
The p75 neurotrophin receptor is a central regulator of glioma invasion. PLoS biology. 2007 Academic Article GET IT
Times cited: 144
Brain-derived neurotrophic factor: a newly described mediator of angiogenesis. Trends in cardiovascular medicine. 2007 Information Resource GET IT
Times cited: 259
Pro-NGF secreted by astrocytes promotes motor neuron cell death. Molecular and cellular neurosciences. 2006 Academic Article GET IT
Times cited: 106
Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science (New York, N.Y.). 2006 Academic Article GET IT
Times cited: 1122
Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006 Academic Article GET IT
Times cited: 66
TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions. Developmental biology. 2006 Academic Article GET IT
Times cited: 23
Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Academic Article GET IT
Times cited: 233
Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Academic Article GET IT
Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron. 2006 Academic Article GET IT
Times cited: 148
Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouse. Circulation. 2005 Academic Article GET IT
Times cited: 18
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression. Nature neuroscience. 2005 Academic Article GET IT
Times cited: 587
Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 345
ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Academic Article GET IT
Times cited: 820
Activation of STAT5-dependent transcription by the neurotrophin receptor Trk. Journal of neurobiology. 2005 Academic Article GET IT
Times cited: 8
Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways. Circulation research. 2005 Academic Article GET IT
Times cited: 21
Coupling neurotrophins to cell migration through selective guanine nucleotide exchange factor activation. Proceedings of the National Academy of Sciences of the United States of America. 2005 Article GET IT
Times cited: 6
Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem cells into angiomyogenic tissue. Circulation. 2005 Academic Article GET IT
Times cited: 48
Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. The Journal of clinical investigation. 2005 Academic Article GET IT
Times cited: 212
Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR. The American journal of pathology. 2005 Academic Article GET IT
Times cited: 152
Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor. The Journal of biological chemistry. 2005 Academic Article GET IT
Times cited: 58
A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival. Blood. 2005 Academic Article GET IT
Times cited: 109
Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science (New York, N.Y.). 2004 Academic Article GET IT
Times cited: 857
Microglia-derived pronerve growth factor promotes photoreceptor cell death via p75 neurotrophin receptor. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 84
Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells. The Journal of biological chemistry. 2004 Academic Article GET IT
Times cited: 163
Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 758
A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptor. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Academic Article GET IT
Times cited: 59
Secreted proNGF is a pathophysiological death-inducing ligand after adult CNS injury. Proceedings of the National Academy of Sciences of the United States of America. 2004 Academic Article GET IT
Times cited: 265
Sortilin is essential for proNGF-induced neuronal cell death. Nature. 2004 Academic Article GET IT
Times cited: 740
Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo. The Journal of clinical investigation. 2004 Academic Article GET IT
Times cited: 329
Essential role for ADAM19 in cardiovascular morphogenesis. Molecular and cellular biology. 2004 Academic Article GET IT
Times cited: 113
Neurotrophins and their receptors: signaling trios in complex biological systems. Cellular and molecular life sciences : CMLS. 2004 Information Resource GET IT
Times cited: 188
Neurotrophins: novel mediators of angiogenesis. Frontiers in bioscience : a journal and virtual library. 2003 Information Resource GET IT
Times cited: 30
Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin. Oncogene. 2003 Academic Article GET IT
Times cited: 81
ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron. 2002 Academic Article GET IT
Times cited: 387
The many faces of p75NTR. Current opinion in neurobiology. 2002 Information Resource GET IT
Times cited: 259
Regulation of cell survival by secreted proneurotrophins. Science (New York, N.Y.). 2001 Academic Article GET IT
Times cited: 1288
The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor. The Journal of biological chemistry. 2001 Academic Article GET IT
Times cited: 187
A novel mutation within the extracellular domain of TrkA causes constitutive receptor activation. Oncogene. 2001 Academic Article GET IT
Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development (Cambridge, England). 2000 Academic Article GET IT
Times cited: 305
Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo. Developmental biology. 2000 Academic Article GET IT
p75(NTR) mediates neurotrophin-induced apoptosis of vascular smooth muscle cells. The American journal of pathology. 2000 Academic Article GET IT
Times cited: 77
Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis. The Journal of biological chemistry. 2000 Academic Article GET IT
Times cited: 44
TrkA immunoglobulin-like ligand binding domains inhibit spontaneous activation of the receptor. Molecular and cellular biology. 2000 Academic Article GET IT
Times cited: 87
Trk C signaling is required for retinal progenitor cell proliferation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Academic Article GET IT
Times cited: 42
Activation of c-Ha-Ras by nitric oxide modulates survival responsiveness in neuronal PC12 cells. The Journal of biological chemistry. 1999 Academic Article GET IT
Times cited: 46
NGF activates similar intracellular signaling pathways in vascular smooth muscle cells as PDGF-BB but elicits different biological responses. Arteriosclerosis, thrombosis, and vascular biology. 1999 Academic Article GET IT
Times cited: 62
Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 1997 Academic Article GET IT
Times cited: 185
Immunohistochemical analysis of the neurotrophins BDNF and NT-3 and their receptors trk B, trk C, and p75 in the developing chick retina. Visual neuroscience. 1997 Academic Article GET IT
Differential modulation of neuron survival during development by nerve growth factor binding to the p75 neurotrophin receptor. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 86
A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction. The Journal of biological chemistry. 1997 Academic Article GET IT
Times cited: 439
v-Crk, an effector of the nerve growth factor signaling pathway, delays apoptotic cell death in neurotrophin-deprived PC12 cells. Cell death and differentiation. 1997 Academic Article GET IT
Dissociation of ngf induced signal transduction from neurite out-growth by expression of a mutant adaptor protein in pc12 cells. Journal of Investigative Medicine. 1996 Article
Neurotrophin and neurotrophin receptors in human fetal kidney. Developmental biology. 1996 Academic Article GET IT
Times cited: 38
Identification of an essential nonneuronal function of neurotrophin 3 in mammalian cardiac development. Nature genetics. 1996 Academic Article GET IT
Times cited: 154
Nerve growth factor signal transduction in human B lymphocytes is mediated by gp140trk. European journal of immunology. 1996 Academic Article GET IT
Times cited: 63
Dissociation of NGF Induced Signal Transduction from Neurite Elongation by Expression of a Mutant Adaptor Protein v-Crk in PC12 Cells. Molecular and cellular neurosciences. 1996 Academic Article GET IT
Immunohistochemical analysis of trk C and P75 expression in the developing chick retina. Investigative Ophthalmology and Visual Science. 1996 Article
Dissociation of NGF induced signal transduction from neurite elongation by expression of a mutant adaptor protein v-Crk in PC12 cells. Molecular and cellular neurosciences. 1996 Academic Article GET IT
Times cited: 14
v-Crk modulation of growth factor-induced PC12 cell differentiation involves the Src homology 2 domain of v-Crk and sustained activation of the Ras/mitogen-activated protein kinase pathway. The Journal of biological chemistry. 1995 Academic Article GET IT
Times cited: 53
Neurotrophin and neurotrophin receptors in vascular smooth muscle cells. Regulation of expression in response to injury. The American journal of pathology. 1995 Academic Article GET IT
Times cited: 261
Expression of trk receptors in the developing and adult human central and peripheral nervous system. The Journal of comparative neurology. 1995 Academic Article GET IT
Times cited: 81
NGF binding to the trk tyrosine kinase receptor requires the extracellular immunoglobulin-like domains. Molecular and cellular neurosciences. 1995 Academic Article GET IT
Times cited: 88
Identification of the neurotrophin receptors p75 and trk in a series of Wilms' tumors. The American journal of pathology. 1994 Academic Article GET IT
Times cited: 39
High affinity nerve growth factor binding displays a faster rate of association than p140trk binding. Implications for multi-subunit polypeptide receptors. The Journal of biological chemistry. 1994 Academic Article GET IT
Times cited: 257
Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways. Molecular and cellular biology. 1994 Academic Article GET IT
Times cited: 81
Immunohistochemical localization of Trk receptor protein in pediatric small round blue cell tumors. The American journal of pathology. 1993 Academic Article GET IT
Times cited: 45
Strategies for modulating Trk receptor activity. Experimental neurology. 1993 Information Resource GET IT
Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron. 1992 Academic Article GET IT
Times cited: 283
The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 1991 Academic Article GET IT
Times cited: 140
Differential expression of MAG isoforms during development. Journal of neuroscience research. 1991 Academic Article GET IT
Times cited: 51
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature. 1991 Academic Article GET IT
Times cited: 995
Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding. The Journal of biological chemistry. 1990 Academic Article GET IT
Times cited: 72
Expression of functional nerve growth factor receptors after gene transfer. Science (New York, N.Y.). 1989 Academic Article GET IT
Times cited: 174
Selective phosphorylation of the IgE receptor in antigen-stimulated rat mast cells. Proceedings of the National Academy of Sciences of the United States of America. 1983 Academic Article GET IT
Times cited: 18
The cell surface receptor for immunoglobulin E. Effect of tunicamycin on molecular properties of receptor from rat basophilic leukemia cells. The Journal of biological chemistry. 1981 Academic Article GET IT
Times cited: 21
Phosphorylation of the IgE receptor from ionophore A23187 stimulated intact rat mast cells. Biochemical and biophysical research communications. 1981 Academic Article GET IT
Times cited: 25
Effect of tunicamycin on the molecular properties of the IgE receptor. Federation Proceedings. 1981 Article
Characterization of the IgE receptor isolated from human basophils. Journal of immunology (Baltimore, Md. : 1950). 1979 Academic Article GET IT
Times cited: 18
The cell surface receptor for immunoglobulin E. II. Properties of the purified biologically active receptor. The Journal of biological chemistry. 1979 Academic Article GET IT
Times cited: 10
Purification of biologically-active IgE receptor. Clinical Research. 1978 Article

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Research

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Funding awarded

Immunomodulatory Ligand B7-1 Targets p75 Neurotrophin Receptor in Neurodegeneration Principal Investigator 2023 - 2026

Weill Cornell Disparities Center of Excellence Co-Investigator 2018 - 2024

Impact of BDNF on the Development of Social Behavior Circuits awarded by National Institute of Mental Health Co-Principal Investigator 2020 - 2025

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Background

education and training

M.D., Ph.D., Washington University School of Medicine 1982
B.A., Tufts University 1976

Contact

full name

Barbara L. Hempstead

primary email

blhempst@med.cornell.edu

VIVO Weill Cornell Medical College

Barbara L. Hempstead Dean of the Weill Cornell Graduate School of Medical Sciences

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email