Nature communications
Journal
Overview
publication venue for
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Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial.
2024
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Author Correction: Comprehensive genomic characterization of HER2-low and HER2-0 breast cancer.
2023
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Author Correction: Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice.
2023
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Author Correction: Genetic features and therapeutic relevance of emergent circulating tumor DNA alterations in refractory non-colorectal gastrointestinal cancers.
2023
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Author Correction: A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus.
2023
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Publisher Correction: Epigenetic landscape reveals MECOM as an endothelial lineage regulator.
2023
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Author Correction: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma.
2023
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Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation.
2022
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Author Correction: Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure.
2022
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Author Correction: Truly privacy-preserving federated analytics for precision medicine with multiparty homomorphic encryption.
2021
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Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses.
2018
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Publisher Correction: Finding influential nodes for integration in brain networks using optimal percolation theory.
2018
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Inflammation and mitophagy are mitochondrial checkpoints to aging..
15.
2024
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The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova..
15.
2024
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Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment..
15.
2024
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SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration..
15.
2024
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A fast-acting lipid checkpoint in G1 prevents mitotic defects..
15.
2024
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The evolution of metastatic upper tract urothelial carcinoma through genomic-transcriptomic and single-cell protein markers analysis..
15.
2024
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Biallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications..
15.
2024
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FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease..
15.
2024
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TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection..
15.
2024
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Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn..
15.
2024
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Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders..
15.
2024
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Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover..
15.
2024
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A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome..
15.
2024
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Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping..
15.
2024
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Fluorogenic CRISPR for genomic DNA imaging..
15.
2024
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Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase..
15.
2024
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Structure of the M. tuberculosis DnaK-GrpE complex reveals how key DnaK roles are controlled..
15.
2024
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Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia..
15.
2024
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Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth..
15.
2024
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Distinct mesenchymal cell states mediate prostate cancer progression..
15.
2024
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Petascale pipeline for precise alignment of images from serial section electron microscopy..
15.
2024
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Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial..
14.
2023
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Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis..
14.
2023
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BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state..
14.
2023
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Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors..
14.
2023
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Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis..
14.
2023
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High-throughput target trial emulation for Alzheimer's disease drug repurposing with real-world data..
14.
2023
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Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase..
14.
2023
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Young infants display heterogeneous serological responses and extensive but reversible transcriptional changes following initial immunizations..
14.
2023
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PhenoSV: interpretable phenotype-aware model for the prioritization of genes affected by structural variants..
14.
2023
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Comprehensive genomic characterization of HER2-low and HER2-0 breast cancer..
14.
2023
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Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide..
14.
2023
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Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15..
14.
2023
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Enhanced clinical assessment of hematologic malignancies through routine paired tumor and normal sequencing..
14.
2023
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Oncogenic context shapes the fitness landscape of tumor suppression..
14.
2023
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A concerted ATPase cycle of the protein transporter AAA-ATPase Bcs1..
14.
2023
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Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice..
14.
2023
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Improving model fairness in image-based computer-aided diagnosis..
14.
2023
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THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer..
14.
2023
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Epitranscriptomic subtyping, visualization, and denoising by global motif visualization..
14.
2023
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Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation..
14.
2023
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A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury..
14.
2023
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Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumors..
14.
2023
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A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus..
14.
2023
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SnapFISH: a computational pipeline to identify chromatin loops from multiplexed DNA FISH data..
14.
2023
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SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates..
14.
2023
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Structural basis of agonist specificity of α1A-adrenergic receptor..
14.
2023
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Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry..
14.
2023
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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation..
14.
2023
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Targeted viral adaptation generates a simian-tropic hepatitis B virus that infects marmoset cells..
14.
2023
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Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A..
14.
2023
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Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture..
14.
2023
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Vaccinia E5 is a major inhibitor of the DNA sensor cGAS..
14.
2023
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Task-specific modulation of corticospinal neuron activity during motor learning in mice..
14.
2023
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Highly host-linked viromes in the built environment possess habitat-dependent diversity and functions for potential virus-host coevolution..
14.
2023
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Symport and antiport mechanisms of human glutamate transporters..
14.
2023
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Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships..
14.
2023
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A machine learning model identifies patients in need of autoimmune disease testing using electronic health records..
14.
2023
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Epigenetic landscape reveals MECOM as an endothelial lineage regulator..
14.
2023
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RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells..
14.
2023
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Inducible expression of interleukin-12 augments the efficacy of affinity-tuned chimeric antigen receptors in murine solid tumor models..
14.
2023
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Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response..
14.
2023
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Data-driven analysis to understand long COVID using electronic health records from the RECOVER initiative..
14.
2023
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Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance..
14.
2023
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The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis..
14.
2023
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Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts..
14.
2023
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mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs..
14.
2023
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Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1..
14.
2023
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On-demand male contraception via acute inhibition of soluble adenylyl cyclase..
14.
2023
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Antitumour activity of neratinib in patients with HER2-mutant advanced biliary tract cancers..
14.
2023
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Epigenomic charting and functional annotation of risk loci in renal cell carcinoma..
14.
2023
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Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis..
14.
2023
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Inferring visual space from ultra-fine extra-retinal knowledge of gaze position..
14.
2023
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Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer..
14.
2023
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Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers..
14.
2023
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Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter's transformation..
14.
2023
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PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression..
13.
2022
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Diverse monogenic subforms of human spermatogenic failure..
13.
2022
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Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration..
13.
2022
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Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program..
13.
2022
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Breast cancer prevention by short-term inhibition of TGFβ signaling..
13.
2022
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Backbone amides are determinants of Cl- selectivity in CLC ion channels..
13.
2022
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Genetic features and therapeutic relevance of emergent circulating tumor DNA alterations in refractory non-colorectal gastrointestinal cancers..
13.
2022
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Membrane-mediated protein interactions drive membrane protein organization..
13.
2022
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mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome..
13.
2022
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High-throughput screening of caterpillars as a platform to study host-microbe interactions and enteric immunity..
13.
2022
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Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies..
13.
2022
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Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population..
13.
2022
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Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel..
13.
2022
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Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration..
13.
2022
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A broadly protective human monoclonal antibody targeting the sialidase activity of influenza A and B virus neuraminidases..
13.
2022
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FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation..
13.
2022
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BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling..
13.
2022
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Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8+ T cell immunity..
13.
2022
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Contact tracing reveals community transmission of COVID-19 in New York City..
13.
2022
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Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression..
13.
2022
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A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma..
13.
2022
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Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs..
13.
2022
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Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain's control energy landscape..
13.
2022
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SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner..
13.
2022
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Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression..
13.
2022
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TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma..
13.
2022
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Modeling tissue-specific breakpoint proximity of structural variations from whole-genomes to identify cancer drivers..
13.
2022
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Batch effects removal for microbiome data via conditional quantile regression..
13.
2022
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In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response..
13.
2022
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Multiplexed mobilization and expression of biosynthetic gene clusters..
13.
2022
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DAXX-ATRX regulation of p53 chromatin binding and DNA damage response..
13.
2022
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Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism..
13.
2022
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Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1..
13.
2022
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Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models..
13.
2022
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SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells..
13.
2022
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Protection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage..
13.
2022
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Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer..
13.
2022
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Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis..
13.
2022
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Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure..
13.
2022
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Therapeutic targeting of ATR in alveolar rhabdomyosarcoma..
13.
2022
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A metagenomic DNA sequencing assay that is robust against environmental DNA contamination..
13.
2022
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AMEERA-1 phase 1/2 study of amcenestrant, SAR439859, in postmenopausal women with ER-positive/HER2-negative advanced breast cancer..
13.
2022
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Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies..
13.
2022
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Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera..
13.
2022
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TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis..
13.
2022
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Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma..
13.
2022
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Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma..
13.
2022
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Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets..
13.
2022
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Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes..
13.
2022
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Sex-specific multi-level 3D genome dynamics in the mouse brain..
13.
2022
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CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes..
13.
2022
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Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx..
13.
2022
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Unraveling function and diversity of bacterial lectins in the human microbiome..
13.
2022
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Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar..
13.
2022
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Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers..
13.
2022
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MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets..
13.
2022
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TMEM16 scramblases thin the membrane to enable lipid scrambling..
13.
2022
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Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer..
13.
2022
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Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia..
13.
2022
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Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells..
13.
2022
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A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis..
13.
2022
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CinA mediates multidrug tolerance in Mycobacterium tuberculosis..
13.
2022
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Snf7 spirals sense and alter membrane curvature..
13.
2022
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Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model..
13.
2022
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Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts..
13.
2022
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Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy..
13.
2022
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Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma..
13.
2022
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Predictive biomarkers for survival benefit with ramucirumab in urothelial cancer in the RANGE trial..
13.
2022
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Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics..
13.
2022
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Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression..
13.
2022
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The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers..
13.
2022
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Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer..
13.
2022
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Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology..
13.
2022
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Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis..
13.
2022
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Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance..
13.
2022
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Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate..
13.
2022
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Live-dead assay on unlabeled cells using phase imaging with computational specificity..
13.
2022
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Relative infectiousness of SARS-CoV-2 vaccine breakthrough infections, reinfections, and primary infections..
13.
2022
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Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration..
13.
2022
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Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation..
13.
2022
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Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease..
13.
2022
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Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract..
13.
2022
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The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer..
12.
2021
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Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis..
12.
2021
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Single molecule kinetics of bacteriorhodopsin by HS-AFM..
12.
2021
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Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights..
12.
2021
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ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury..
12.
2021
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The genetic architecture of DNA replication timing in human pluripotent stem cells..
12.
2021
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G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer..
12.
2021
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HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway..
12.
2021
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Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection..
12.
2021
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Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer..
12.
2021
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Nuclear S-nitrosylation impacts tissue regeneration in zebrafish..
12.
2021
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Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus..
12.
2021
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Clonal hematopoiesis is associated with risk of severe Covid-19..
12.
2021
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Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes..
12.
2021
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Truly privacy-preserving federated analytics for precision medicine with multiparty homomorphic encryption..
12.
2021
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Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer..
12.
2021
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DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation..
12.
2021
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Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression..
12.
2021
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Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia..
12.
2021
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Metabolic requirements of NK cells during the acute response against retroviral infection..
12.
2021
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β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture..
12.
2021
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Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia..
12.
2021
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The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice..
12.
2021
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Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers..
12.
2021
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Heritability and interindividual variability of regional structure-function coupling..
12.
2021
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ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer..
12.
2021
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Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice..
12.
2021
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Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM..
12.
2021
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Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system..
12.
2021
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Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion..
12.
2021
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SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts..
12.
2021
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Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis..
12.
2021
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3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine..
12.
2021
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Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data..
12.
2021
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Correlation of membrane protein conformational and functional dynamics..
12.
2021
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Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades..
12.
2021
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DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes..
12.
2021
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Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS..
12.
2021
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Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection..
12.
2021
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Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice..
12.
2021
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Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission..
12.
2021
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Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2..
12.
2021
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Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer..
12.
2021
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Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues..
12.
2021
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Mining mutation contexts across the cancer genome to map tumor site of origin..
12.
2021
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Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility..
12.
2021
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Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators..
12.
2021
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NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ..
12.
2021
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Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice..
12.
2021
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Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging..
12.
2021
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Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway..
12.
2021
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Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction..
12.
2021
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Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions..
12.
2021
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Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19..
12.
2021
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Revealing the role of the human blood plasma proteome in obesity using genetic drivers..
12.
2021
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Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits..
12.
2021
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Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis..
12.
2021
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Patient-derived xenografts and organoids model therapy response in prostate cancer..
12.
2021
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A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers..
12.
2021
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ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism..
12.
2021
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Mutant-selective degradation by BRAF-targeting PROTACs..
12.
2021
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Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes..
12.
2021
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Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide..
12.
2021
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Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma..
12.
2021
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Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors..
12.
2021
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PDX1LOW MAFALOW β-cells contribute to islet function and insulin release..
12.
2021
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Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification..
12.
2021
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GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers..
12.
2021
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A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain..
12.
2021
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Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis..
12.
2021
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HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA)..
12.
2021
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Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site..
12.
2021
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Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel..
11.
2020
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Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages..
11.
2020
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Phase imaging with computational specificity (PICS) for measuring dry mass changes in sub-cellular compartments..
11.
2020
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Common germline-somatic variant interactions in advanced urothelial cancer..
11.
2020
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CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function..
11.
2020
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Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing..
11.
2020
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Training confounder-free deep learning models for medical applications..
11.
2020
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Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9..
11.
2020
-
Transient commensal clonal interactions can drive tumor metastasis..
11.
2020
-
MEKK2 mediates aberrant ERK activation in neurofibromatosis type I..
11.
2020
-
A circular RNA generated from an intron of the insulin gene controls insulin secretion..
11.
2020
-
Broad genic repression domains signify enhanced silencing of oncogenes..
11.
2020
-
Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread..
11.
2020
-
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity..
11.
2020
-
Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity..
11.
2020
-
Prevalent and sex-biased breathing patterns modify functional connectivity MRI in young adults..
11.
2020
-
A strategy to incorporate prior knowledge into correlation network cutoff selection..
11.
2020
-
Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations..
11.
2020
-
The hierarchical assembly of septins revealed by high-speed AFM..
11.
2020
-
Millisecond dynamics of an unlabeled amino acid transporter..
11.
2020
-
Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma..
11.
2020
-
T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration..
11.
2020
-
A shared genetic contribution to breast cancer and schizophrenia..
11.
2020
-
Enhancing mucosal immunity by transient microbiota depletion..
11.
2020
-
Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C..
11.
2020
-
An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution..
11.
2020
-
Clearance of HIV infection by selective elimination of host cells capable of producing HIV..
11.
2020
-
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine..
11.
2020
-
Escape from nonsense-mediated decay associates with anti-tumor immunogenicity..
11.
2020
-
Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer..
11.
2020
-
Accelerated single cell seeding in relapsed multiple myeloma..
11.
2020
-
ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment..
11.
2020
-
Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling..
11.
2020
-
Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant..
11.
2020
-
Machine learning uncovers cell identity regulator by histone code..
11.
2020
-
Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers..
11.
2020
-
FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth..
11.
2020
-
DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis..
11.
2020
-
Protein-altering germline mutations implicate novel genes related to lung cancer development..
11.
2020
-
Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers..
11.
2020
-
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation..
11.
2020
-
Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression..
11.
2020
-
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation..
11.
2020
-
Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues..
11.
2020
-
HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells..
11.
2020
-
Integrative multiplatform molecular profiling of benign prostatic hyperplasia identifies distinct subtypes..
11.
2020
-
Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts..
11.
2020
-
Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis..
11.
2020
-
Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics..
11.
2020
-
A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes..
11.
2020
-
Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction..
11.
2020
-
Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability..
11.
2020
-
Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory..
11.
2020
-
Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome..
11.
2020
-
NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle..
11.
2020
-
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release..
11.
2020
-
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns..
11.
2020
-
Combined burden and functional impact tests for cancer driver discovery using DriverPower..
11.
2020
-
Genomic footprints of activated telomere maintenance mechanisms in cancer..
11.
2020
-
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations..
11.
2020
-
Integrative pathway enrichment analysis of multivariate omics data..
11.
2020
-
Pathway and network analysis of more than 2500 whole cancer genomes..
11.
2020
-
Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF..
11.
2020
-
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis..
11.
2020
-
Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements..
11.
2020
-
Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer..
11.
2020
-
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis..
11.
2020
-
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction..
11.
2020
-
Annexin-V stabilizes membrane defects by inducing lipid phase transition..
11.
2020
-
BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins..
11.
2020
-
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits..
11.
2020
-
ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
2020
-
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection..
10.
2019
-
Molecular determinants of nephron vascular specialization in the kidney..
10.
2019
-
Short-term availability of adult-born neurons for memory encoding..
10.
2019
-
Conformational pathway provides unique sensitivity to a synaptic mGluR..
10.
2019
-
Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection..
10.
2019
-
Using somatic variant richness to mine signals from rare variants in the cancer genome..
10.
2019
-
A Bayesian machine learning approach for drug target identification using diverse data types..
10.
2019
-
Mapping the perturbome network of cellular perturbations..
10.
2019
-
Antibody cross-reactivity accounts for widespread appearance of m1A in 5'UTRs..
10.
2019
-
Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16..
10.
2019
-
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development..
10.
2019
-
Colonizing multidrug-resistant bacteria and the longitudinal evolution of the intestinal microbiome after liver transplantation..
10.
2019
-
Engineering transferrable microvascular meshes for subcutaneous islet transplantation..
10.
2019
-
Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23..
10.
2019
-
Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity..
10.
2019
-
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program..
10.
2019
-
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle..
10.
2019
-
Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells..
10.
2019
-
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations..
10.
2019
-
Accurate detection of m6A RNA modifications in native RNA sequences..
10.
2019
-
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K..
10.
2019
-
Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences..
10.
2019
-
Wilm's tumor 1 promotes memory flexibility..
10.
2019
-
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis..
10.
2019
-
IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation..
10.
2019
-
Non-coding variability at the APOE locus contributes to the Alzheimer's risk..
10.
2019
-
Alternative splicing regulates stochastic NLRP3 activity..
10.
2019
-
Predictive metabolomic profiling of microbial communities using amplicon or metagenomic sequences..
10.
2019
-
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling..
10.
2019
-
Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis..
10.
2019
-
Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents..
10.
2019
-
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression..
10.
2019
-
Chromatin organization in the female mouse brain fluctuates across the oestrous cycle..
10.
2019
-
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases..
10.
2019
-
HIV-1 DNA sequence diversity and evolution during acute subtype C infection..
10.
2019
-
Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation..
10.
2019
-
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia..
10.
2019
-
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence..
10.
2019
-
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus..
10.
2019
-
Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease..
10.
2019
-
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL..
10.
2019
-
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα..
10.
2019
-
Breast cancer quantitative proteome and proteogenomic landscape..
10.
2019
-
Sec14l3 potentiates VEGFR2 signaling to regulate zebrafish vasculogenesis..
10.
2019
-
Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer..
10.
2019
-
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression..
10.
2019
-
Reversible histone glycation is associated with disease-related changes in chromatin architecture..
10.
2019
-
Restoration of high-sensitivity and adapting vision with a cone opsin..
10.
2019
-
Flagellar cAMP signaling controls trypanosome progression through host tissues..
10.
2019
-
Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response..
10.
2019
-
Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide..
10.
2019
-
Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion..
10.
2019
-
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response..
10.
2019
-
Single-molecule sequencing detection of N6-methyladenine in microbial reference materials..
10.
2019
-
ONECUT2 is a driver of neuroendocrine prostate cancer..
10.
2019
-
The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors..
10.
2019
-
Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis..
9.
2018
-
Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy..
9.
2018
-
High-speed AFM height spectroscopy reveals µs-dynamics of unlabeled biomolecules..
9.
2018
-
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival..
9.
2018
-
Inflammation-induced Id2 promotes plasticity in regulatory T cells..
9.
2018
-
Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model..
9.
2018
-
Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics..
9.
2018
-
Testicular endothelial cells are a critical population in the germline stem cell niche..
9.
2018
-
ZZ-dependent regulation of p62/SQSTM1 in autophagy..
9.
2018
-
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons..
9.
2018
-
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference..
9.
2018
-
A missense variant in SLC39A8 is associated with severe idiopathic scoliosis..
9.
2018
-
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism..
9.
2018
-
Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer..
9.
2018
-
Bone protection by inhibition of microRNA-182..
9.
2018
-
An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel..
9.
2018
-
Genus-wide sequencing supports a two-locus model for sex-determination in Phoenix..
9.
2018
-
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones..
9.
2018
-
Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function..
9.
2018
-
The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice..
9.
2018
-
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis..
9.
2018
-
Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses..
9.
2018
-
Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors..
9.
2018
-
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease..
9.
2018
-
Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase..
9.
2018
-
Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine..
9.
2018
-
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma..
9.
2018
-
Simplified ChIP-exo assays..
9.
2018
-
PRMT5-mediated regulation of developmental myelination..
9.
2018
-
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b..
9.
2018
-
Discovery of a drug candidate for GLIS3-associated diabetes..
9.
2018
-
Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease..
9.
2018
-
Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract..
9.
2018
-
Patient derived organoids to model rare prostate cancer phenotypes..
9.
2018
-
Helicase promotes replication re-initiation from an RNA transcript..
9.
2018
-
Finding influential nodes for integration in brain networks using optimal percolation theory..
9.
2018
-
Male germ cells support long-term propagation of Zika virus..
9.
2018
-
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models..
9.
2018
-
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas..
9.
2018
-
Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma..
9.
2018
-
Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer..
9.
2018
-
Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28..
9.
2018
-
Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models..
9.
2018
-
Increased formate overflow is a hallmark of oxidative cancer..
9.
2018
-
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors..
9.
2018
-
Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer..
9.
2018
-
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis..
9.
2018
-
Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation..
9.
2018
-
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy..
9.
2018
-
A community approach to mortality prediction in sepsis via gene expression analysis..
9.
2018
-
Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models..
9.
2018
-
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α..
9.
2018
-
Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor..
9.
2018
-
Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1..
9.
2018
-
Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population..
9.
2018
-
A general and flexible method for signal extraction from single-cell RNA-seq data..
9.
2018
-
A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport..
9.
2018
-
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis..
9.
2018
-
Target engagement imaging of PARP inhibitors in small-cell lung cancer..
9.
2018
-
Peptidomimetic blockade of MYB in acute myeloid leukemia..
9.
2018
-
Weakly perturbative imaging of interfacial water with submolecular resolution by atomic force microscopy..
9.
2018
-
Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5..
9.
2018
-
Improved split fluorescent proteins for endogenous protein labeling.
8:1-11.
2018
-
Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer..
8.
2017
-
The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy..
8.
2017
-
EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer..
8.
2017
-
Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor..
8.
2017
-
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells..
8.
2017
-
Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages..
8.
2017
-
Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes..
8.
2017
-
Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes..
8.
2017
-
Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway..
8.
2017
-
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology..
8.
2017
-
mTOR intersects antibody-inducing signals from TACI in marginal zone B cells..
8.
2017
-
Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions..
8.
2017
-
Resistance to checkpoint blockade therapy through inactivation of antigen presentation..
8.
2017
-
Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis..
8.
2017
-
Ets transcription factor GABP controls T cell homeostasis and immunity..
8.
2017
-
The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions..
8.
2017
-
TRIM29 promotes DNA virus infections by inhibiting innate immune response..
8.
2017
-
Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition..
8.
2017
-
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop..
8.
2017
-
An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses..
8.
2017
-
Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes..
8.
2017
-
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice..
8.
2017
-
A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice..
8.
2017
-
Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria..
8.
2017
-
Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer..
8.
2017
-
ATRX is a regulator of therapy induced senescence in human cells..
8.
2017
-
ROCKII inhibition promotes the maturation of human pancreatic beta-like cells..
8.
2017
-
The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity..
8.
2017
-
Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells..
8.
2017
-
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm..
8.
2017
-
Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy..
8.
2017
-
Transancestral mapping and genetic load in systemic lupus erythematosus..
8.
2017
-
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine..
8.
2017
-
Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target..
8.
2017
-
Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis..
8.
2017
-
The m6A pathway facilitates sex determination in Drosophila..
8.
2017
-
Inherited determinants of early recurrent somatic mutations in prostate cancer..
8.
2017
-
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity..
8.
2017
-
Correspondence: DNA shape is insufficient to explain binding..
8.
2017
-
Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer..
8.
2017
-
Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations..
8.
2017
-
Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors..
8.
2017
-
ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia..
8.
2017
-
An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data..
8.
2017
-
DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6..
8.
2017
-
The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility..
8.
2017
-
Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma..
8.
2017
-
Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death..
8.
2017
-
An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells..
8.
2017
-
Connecting genetic risk to disease end points through the human blood plasma proteome..
8.
2017
-
Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits..
8.
2017
-
Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization..
8.
2017
-
SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts..
8.
2017
-
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity..
8.
2017
-
Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma..
8.
2017
-
Topical tacrolimus for the treatment of secondary lymphedema..
8.
2017
-
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia..
8.
2017
-
THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors..
8.
2017
-
Sox17 drives functional engraftment of endothelium converted from non-vascular cells..
8.
2017
-
Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis..
7.
2016
-
Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire..
7.
2016
-
DNA looping mediates nucleosome transfer..
7.
2016
-
Increased global transcription activity as a mechanism of replication stress in cancer..
7.
2016
-
Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets..
7.
2016
-
Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants..
7.
2016
-
FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase..
7.
2016
-
Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter..
7.
2016
-
Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels..
7.
2016
-
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus..
7.
2016
-
ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival..
7.
2016
-
TP53 mutations emerge with HDM2 inhibitor SAR405838 treatment in de-differentiated liposarcoma..
7.
2016
-
Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells..
7.
2016
-
PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis..
7.
2016
-
Deconvoluting hepatic processing of carbon nanotubes..
7.
2016
-
Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal..
7.
2016
-
The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis..
7.
2016
-
Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus..
7.
2016
-
A rhesus macaque model of Asian-lineage Zika virus infection..
7.
2016
-
miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy..
7.
2016
-
Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis..
7.
2016
-
Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy..
7.
2016
-
Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics..
7.
2016
-
Simultaneous optical and electrical in vivo analysis of the enteric nervous system..
7.
2016
-
A method to rapidly create protein aggregates in living cells..
7.
2016
-
Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories..
7.
2016
-
The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells..
7.
2016
-
Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms..
7.
2016
-
Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation..
7.
2016
-
Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease..
7.
2016
-
Laminin regulates PDGFRβ(+) cell stemness and muscle development..
7.
2016
-
Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells..
7.
2016
-
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer..
7.
2016
-
Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy..
7.
2016
-
Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis..
7.
2016
-
The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures..
7.
2016
-
FAT1 mutations cause a glomerulotubular nephropathy..
7.
2016
-
MSI2 is required for maintaining activated myelodysplastic syndrome stem cells..
7.
2016
-
Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer..
7.
2016
-
Genome-wide association and high-resolution phenotyping link Oryza sativa panicle traits to numerous trait-specific QTL clusters..
7.
2016
-
Microbial metabolomics in open microscale platforms..
7.
2016
-
Open access resources for genome-wide association mapping in rice..
7.
2016
-
Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius..
7.
2016
-
Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis..
7.
2016
-
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile..
7.
2016
-
Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish..
7.
2016
-
Bcl-xL promotes metastasis independent of its anti-apoptotic activity..
7.
2016
-
CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking..
7.
2016
-
T7 replisome directly overcomes DNA damage..
6.
2015
-
miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity..
6.
2015
-
Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma..
6.
2015
-
Whole genome re-sequencing of date palms yields insights into diversification of a fruit tree crop..
6.
2015
-
Formation of functional super-helical assemblies by constrained single heptad repeat..
6.
2015
-
Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike..
6.
2015
-
Calcium ions open a selectivity filter gate during activation of the MthK potassium channel..
6.
2015
-
Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA..
6.
2015
-
GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation..
6.
2015
-
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis..
6.
2015
-
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke..
6.
2015
-
Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions..
6.
2015
-
PTEN regulates DNA replication progression and stalled fork recovery..
6.
2015
-
IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection..
6.
2015
-
Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours..
6.
2015
-
Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization..
6.
2015
-
Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE..
6.
2015
-
FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization..
6.
2015
-
Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation..
6.
2015
-
Coupled local translation and degradation regulate growth cone collapse..
6.
2015
-
Epigenomic evolution in diffuse large B-cell lymphomas..
6.
2015
-
miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β..
6.
2015
-
Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy..
6.
2015
-
ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype..
6.
2015
-
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer..
6.
2015
-
Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia..
6.
2015
-
FAAH genetic variation enhances fronto-amygdala function in mouse and human..
6.
2015
-
Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity..
6.
2015
-
Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env..
6.
2015
-
Numerical chromosomal instability mediates susceptibility to radiation treatment..
6.
2015
-
Annexin A2 promotes phagophore assembly by enhancing Atg16L⁺ vesicle biogenesis and homotypic fusion..
6.
2015
-
Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery..
6.
2015
-
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis..
6.
2015
-
CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes..
6.
2015
-
A genome-wide association study of marginal zone lymphoma shows association to the HLA region..
6.
2015
-
The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch..
5.
2014
-
ERG induces taxane resistance in castration-resistant prostate cancer..
5.
2014
-
Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin..
5.
2014
-
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer..
5.
2014
-
The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication..
5.
2014
-
Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation..
5.
2014
-
Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers..
5.
2014
-
Microwave purification of large-area horizontally aligned arrays of single-walled carbon nanotubes..
5.
2014
-
The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction..
5.
2014
-
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk..
5.
2014
-
Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines..
5.
2014
-
An authentic imaging probe to track cell fate from beginning to end..
5.
2014
-
Constitutive phospholipid scramblase activity of a G protein-coupled receptor..
5.
2014
-
Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21(CDKN1A)..
5.
2014
-
Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment..
5.
2014
-
Assessing technical performance in differential gene expression experiments with external spike-in RNA control ratio mixtures..
5.
2014
-
Activation of diverse signalling pathways by oncogenic PIK3CA mutations..
5.
2014
-
Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation..
5.
2014
-
Membrane curvature sensing by the C-terminal domain of complexin..
5.
2014
-
Circadian rhythm reprogramming during lung inflammation..
5.
2014
-
Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice..
5.
2014
-
TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour..
5.
2014
-
Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming..
5.
2014
-
Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression..
5.
2014
-
Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators..
5.
2014
-
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis..
5.
2014
-
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity..
5.
2014
-
Sema3E/PlexinD1 regulates the migration of hem-derived Cajal-Retzius cells in developing cerebral cortex..
5.
2014
-
p38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppression..
5.
2014
-
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel..
5.
2014
-
The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism..
5.
2014
-
Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells..
5.
2014
-
Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma..
5.
2014
-
Mid-range Ca2+ signalling mediated by functional coupling between store-operated Ca2+ entry and IP3-dependent Ca2+ release..
5.
2014
-
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration..
5.
2014
-
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids..
5.
2014
-
MTSS1 is a metastasis driver in a subset of human melanomas..
5.
2014
-
Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching..
5.
2014
-
A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages..
5.
2014
-
Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development..
5.
2014
-
Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon..
5.
2014
-
Kinase fusions are frequent in Spitz tumours and spitzoid melanomas..
5.
2014
-
Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1..
5.
2014
-
Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle..
5.
2014
-
microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition..
5.
2014
-
A hybrid high-speed atomic force-optical microscope for visualizing single membrane proteins on eukaryotic cells..
4.
2013
-
Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel..
4.
2013
-
Dimensionality of brain networks linked to life-long individual differences in self-control..
4.
2013
-
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer..
4.
2013
-
Equilibrium selectivity alone does not create K+-selective ion conduction in K+ channels..
4.
2013
-
Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation..
4.
2013
-
Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31..
4.
2013
-
InVERT molding for scalable control of tissue microarchitecture..
4.
2013
-
Influenza A(H7N9) virus gains neuraminidase inhibitor resistance without loss of in vivo virulence or transmissibility..
4.
2013
-
Mycobacterium tuberculosis is extraordinarily sensitive to killing by a vitamin C-induced Fenton reaction..
4.
2013
-
RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription..
4.
2013
-
Torque modulates nucleosome stability and facilitates H2A/H2B dimer loss..
4.
2013
-
Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction..
4.
2013
-
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression..
3.
2012
-
Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris..
3.
2012
-
Evidence of an inhibitory restraint of seizure activity in humans..
3.
2012
-
Multiplexed volumetric bar-chart chip for point-of-care diagnostics..
3.
2012
-
Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa..
2.
2011
-
Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling..
2.
2011
-
Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17..
2.
2011
-
Structure and Scm3-mediated assembly of budding yeast centromeric nucleosomes..
2.
2011
-
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells..
2.
2011
-
Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation..
2.
2011
-
A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors..
1.
2010
-
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy..
1.
2010
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