Nature communications

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Author Correction: ChromaFold predicts the 3D contact map from single-cell chromatin accessibility. 2025
Author Correction: The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova. 2024
Author Correction: Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer. 2024
Author Correction: Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins. 2024
Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial. 2024
Author Correction: Comprehensive genomic characterization of HER2-low and HER2-0 breast cancer. 2023
Author Correction: Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice. 2023
Author Correction: A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus. 2023
Publisher Correction: Epigenetic landscape reveals MECOM as an endothelial lineage regulator. 2023
Author Correction: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma. 2023
Author Correction: FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation. 2022
Author Correction: Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure. 2022
Author Correction: Truly privacy-preserving federated analytics for precision medicine with multiparty homomorphic encryption. 2021
Publisher Correction: Mnemonic prediction errors bias hippocampal states. 2020
Publisher Correction: ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression. 2019
Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses. 2018
Publisher Correction: Finding influential nodes for integration in brain networks using optimal percolation theory. 2018
Corrigendum: A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. 2017
Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE.. 16. 2025
Structural insights into terminal arabinosylation of mycobacterial cell wall arabinan.. 16. 2025
MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer.. 16. 2025
An unsupervised map of excitatory neuron dendritic morphology in the mouse visual cortex.. 16. 2025
Stabilized carbon coating on microelectrodes for scalable and interoperable neurotransmitter sensing.. 16. 2025
Long COVID after SARS-CoV-2 during pregnancy in the United States.. 16. 2025
Astrocyte-secreted cues promote neural maturation and augment activity in human forebrain organoids.. 16. 2025
Direct measurement of the male germline mutation rate in individuals using sequential sperm samples.. 16. 2025
Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases.. 16. 2025
Individual bioenergetic capacity as a potential source of resilience to Alzheimer's disease.. 16. 2025
Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel.. 16. 2025
A structural biology compatible file format for atomic force microscopy.. 16. 2025
Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes.. 16. 2025
Testosterone exacerbates neutrophilia and cardiac injury in myocardial infarction via actions in bone marrow.. 16. 2025
Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex.. 16. 2025
Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of V_H3 and V_K3 genes.. 16. 2025
Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity.. 16. 2025
Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice.. 16. 2025
Altered mitochondria-associated ER membrane (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS).. 16. 2025
Deeper response predicts better outcomes in high-risk-smoldering-myeloma: results of the I-PRISM phase II clinical trial.. 16. 2025
STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration.. 16. 2025
DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells.. 15. 2024
Direct perception of affective valence from vision.. 15. 2024
Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice.. 15. 2024
Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate.. 15. 2024
Group 2 innate lymphoid cells are a non-redundant source of interleukin-5 required for development and function of murine B1 cells.. 15. 2024
Neuronal diversity and stereotypy at multiple scales through whole brain morphometry.. 15. 2024
Deep generative AI models analyzing circulating orphan non-coding RNAs enable detection of early-stage lung cancer.. 15. 2024
Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer.. 15. 2024
Whole genome CRISPRi screening identifies druggable vulnerabilities in an isoniazid resistant strain of Mycobacterium tuberculosis.. 15. 2024
Harnessing the regenerative potential of interleukin11 to enhance heart repair.. 15. 2024
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility.. 15. 2024
Uncoupling of mTORC1 from E2F activity maintains DNA damage and senescence.. 15. 2024
Mechanisms of epigenomic and functional convergence between glucocorticoid- and IL4-driven macrophage programming.. 15. 2024
Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome.. 15. 2024
Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice.. 15. 2024
Strengthening and expanding capacities in clinical trials: advancing pandemic prevention, preparedness and response in Africa.. 15. 2024
Towards geospatially-resolved public-health surveillance via wastewater sequencing.. 15. 2024
PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK.. 15. 2024
Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections.. 15. 2024
Automatic ploidy prediction and quality assessment of human blastocysts using time-lapse imaging.. 15. 2024
Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K_2P channel TALK-2.. 15. 2024
Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue.. 15. 2024
Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation.. 15. 2024
A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes.. 15. 2024
Lineage-specific canonical and non-canonical activity of EZH2 in advanced prostate cancer subtypes.. 15. 2024
Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion.. 15. 2024
Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization.. 15. 2024
Mutant mice with rod-specific VPS35 deletion exhibit retinal α-synuclein pathology-associated degeneration.. 15. 2024
Combined inhibition of KRAS^G12C and mTORC1 kinase is synergistic in non-small cell lung cancer.. 15. 2024
Cytomegalovirus vaccine vector-induced effector memory CD4 + T cells protect cynomolgus macaques from lethal aerosolized heterologous avian influenza challenge.. 15. 2024
Controlled human hookworm infection remodels plasmacytoid dendritic cells and regulatory T cells towards profiles seen in natural infections in endemic areas.. 15. 2024
Molecular profiling of 888 pediatric tumors informs future precision trials and data-sharing initiatives in pediatric cancer.. 15. 2024
Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis.. 15. 2024
HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy.. 15. 2024
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.. 15. 2024
Structural basis for hyperpolarization-dependent opening of human HCN1 channel.. 15. 2024
C-terminally phosphorylated p27 activates self-renewal driver genes to program cancer stem cell expansion, mammary hyperplasia and cancer.. 15. 2024
Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2.. 15. 2024
Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium.. 15. 2024
Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA).. 15. 2024
Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction.. 15. 2024
Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses.. 15. 2024
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight.. 15. 2024
Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight.. 15. 2024
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight.. 15. 2024
Space radiation damage rescued by inhibition of key spaceflight associated miRNAs.. 15. 2024
Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight.. 15. 2024
Spatiotemporal expression and control of haemoglobin in space.. 15. 2024
Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels.. 15. 2024
The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis.. 15. 2024
Glucocorticoids paradoxically promote steroid resistance in B cell acute lymphoblastic leukemia through CXCR4/PLC signaling.. 15. 2024
Integrating human endogenous retroviruses into transcriptome-wide association studies highlights novel risk factors for major psychiatric conditions.. 15. 2024
Neuroprotective gap-junction-mediated bystander transformations in the adult zebrafish spinal cord after injury.. 15. 2024
Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin.. 15. 2024
Determinants of mosaic chromosomal alteration fitness.. 15. 2024
A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin.. 15. 2024
Targeted small molecule inhibitors blocking the cytolytic effects of pneumolysin and homologous toxins.. 15. 2024
Salmonella exploits membrane reservoirs for invasion of host cells.. 15. 2024
The recent rapid expansion of multidrug resistant Ural lineage Mycobacterium tuberculosis in Moldova.. 15. 2024
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.. 15. 2024
SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration.. 15. 2024
A fast-acting lipid checkpoint in G1 prevents mitotic defects.. 15. 2024
The evolution of metastatic upper tract urothelial carcinoma through genomic-transcriptomic and single-cell protein markers analysis.. 15. 2024
Biallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications.. 15. 2024
FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.. 15. 2024
TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection.. 15. 2024
Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn.. 15. 2024
Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders.. 15. 2024
Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover.. 15. 2024
Molecular basis of VEGFR1 autoinhibition at the plasma membrane.. 15. 2024
A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome.. 15. 2024
Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping.. 15. 2024
Fluorogenic CRISPR for genomic DNA imaging.. 15. 2024
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.. 15. 2024
Structure of the M. tuberculosis DnaK-GrpE complex reveals how key DnaK roles are controlled.. 15. 2024
Engineering tumor-colonizing E. coli Nissle 1917 for detection and treatment of colorectal neoplasia.. 15. 2024
Bispecific BCMA/CD24 CAR-T cells control multiple myeloma growth.. 15. 2024
HHV-6B detection and host gene expression implicate HHV-6B as pulmonary pathogen after hematopoietic cell transplant.. 15. 2024
Distinct mesenchymal cell states mediate prostate cancer progression.. 15. 2024
Petascale pipeline for precise alignment of images from serial section electron microscopy.. 15. 2024
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial.. 14. 2023
Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis.. 14. 2023
BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state.. 14. 2023
Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors.. 14. 2023
Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis.. 14. 2023
High-throughput target trial emulation for Alzheimer's disease drug repurposing with real-world data.. 14. 2023
Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase.. 14. 2023
Young infants display heterogeneous serological responses and extensive but reversible transcriptional changes following initial immunizations.. 14. 2023
Label-free identification of protein aggregates using deep learning.. 14. 2023
PhenoSV: interpretable phenotype-aware model for the prioritization of genes affected by structural variants.. 14. 2023
Comprehensive genomic characterization of HER2-low and HER2-0 breast cancer.. 14. 2023
Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide.. 14. 2023
Dietary L-Tryptophan consumption determines the number of colonic regulatory T cells and susceptibility to colitis via GPR15.. 14. 2023
A phosphoinositide switch mediates exocyst recruitment to multivesicular endosomes for exosome secretion.. 14. 2023
Enhanced clinical assessment of hematologic malignancies through routine paired tumor and normal sequencing.. 14. 2023
Oncogenic context shapes the fitness landscape of tumor suppression.. 14. 2023
A concerted ATPase cycle of the protein transporter AAA-ATPase Bcs1.. 14. 2023
Positive regulation of oxidative phosphorylation by nuclear myosin 1 protects cells from metabolic reprogramming and tumorigenesis in mice.. 14. 2023
Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin.. 14. 2023
Improving model fairness in image-based computer-aided diagnosis.. 14. 2023
THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer.. 14. 2023
Epitranscriptomic subtyping, visualization, and denoising by global motif visualization.. 14. 2023
Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation.. 14. 2023
A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury.. 14. 2023
MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia.. 14. 2023
Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumors.. 14. 2023
Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex.. 14. 2023
A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus.. 14. 2023
SnapFISH: a computational pipeline to identify chromatin loops from multiplexed DNA FISH data.. 14. 2023
SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates.. 14. 2023
Structural basis of agonist specificity of α_1A-adrenergic receptor.. 14. 2023
MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation.. 14. 2023
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.. 14. 2023
Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates.. 14. 2023
Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation.. 14. 2023
A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable pancreatic adenocarcinoma.. 14. 2023
Targeted viral adaptation generates a simian-tropic hepatitis B virus that infects marmoset cells.. 14. 2023
Substrate binding-induced conformational transitions in the omega-3 fatty acid transporter MFSD2A.. 14. 2023
A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8.. 14. 2023
Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture.. 14. 2023
Vaccinia E5 is a major inhibitor of the DNA sensor cGAS.. 14. 2023
Task-specific modulation of corticospinal neuron activity during motor learning in mice.. 14. 2023
Highly host-linked viromes in the built environment possess habitat-dependent diversity and functions for potential virus-host coevolution.. 14. 2023
Symport and antiport mechanisms of human glutamate transporters.. 14. 2023
Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships.. 14. 2023
A machine learning model identifies patients in need of autoimmune disease testing using electronic health records.. 14. 2023
Epigenetic landscape reveals MECOM as an endothelial lineage regulator.. 14. 2023
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells.. 14. 2023
Bladder cancer organoids as a functional system to model different disease stages and therapy response.. 14. 2023
Inducible expression of interleukin-12 augments the efficacy of affinity-tuned chimeric antigen receptors in murine solid tumor models.. 14. 2023
Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response.. 14. 2023
Data-driven analysis to understand long COVID using electronic health records from the RECOVER initiative.. 14. 2023
Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance.. 14. 2023
The evolution of antibiotic resistance is associated with collateral drug phenotypes in Mycobacterium tuberculosis.. 14. 2023
Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts.. 14. 2023
mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs.. 14. 2023
Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1.. 14. 2023
On-demand male contraception via acute inhibition of soluble adenylyl cyclase.. 14. 2023
Antitumour activity of neratinib in patients with HER2-mutant advanced biliary tract cancers.. 14. 2023
Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of β-cell failure.. 14. 2023
Transcriptional reprogramming of skeletal muscle stem cells by the niche environment.. 14. 2023
Epigenomic charting and functional annotation of risk loci in renal cell carcinoma.. 14. 2023
Cytotoxic CD8⁺ T cells target citrullinated antigens in rheumatoid arthritis.. 14. 2023
Inferring visual space from ultra-fine extra-retinal knowledge of gaze position.. 14. 2023
Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer.. 14. 2023
Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers.. 14. 2023
Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter's transformation.. 14. 2023
PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression.. 13. 2022
Diverse monogenic subforms of human spermatogenic failure.. 13. 2022
Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration.. 13. 2022
Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program.. 13. 2022
Breast cancer prevention by short-term inhibition of TGFβ signaling.. 13. 2022
Backbone amides are determinants of Cl^- selectivity in CLC ion channels.. 13. 2022
The dynamic clustering of insulin receptor underlies its signaling and is disrupted in insulin resistance.. 13. 2022
Membrane-mediated protein interactions drive membrane protein organization.. 13. 2022
mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome.. 13. 2022
High-throughput screening of caterpillars as a platform to study host-microbe interactions and enteric immunity.. 13. 2022
Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies.. 13. 2022
Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population.. 13. 2022
Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel.. 13. 2022
Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel.. 13. 2022
Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration.. 13. 2022
Collaborative study from the Bladder Cancer Advocacy Network for the genomic analysis of metastatic urothelial cancer.. 13. 2022
A broadly protective human monoclonal antibody targeting the sialidase activity of influenza A and B virus neuraminidases.. 13. 2022
FOXA1 repression drives lineage plasticity and immune heterogeneity in bladder cancers with squamous differentiation.. 13. 2022
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling.. 13. 2022
Administration of broadly neutralizing anti-HIV-1 antibodies at ART initiation maintains long-term CD8⁺ T cell immunity.. 13. 2022
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.. 13. 2022
A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma.. 13. 2022
Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs.. 13. 2022
Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain's control energy landscape.. 13. 2022
SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner.. 13. 2022
Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression.. 13. 2022
TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma.. 13. 2022
Modeling tissue-specific breakpoint proximity of structural variations from whole-genomes to identify cancer drivers.. 13. 2022
Batch effects removal for microbiome data via conditional quantile regression.. 13. 2022
In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response.. 13. 2022
Multiplexed mobilization and expression of biosynthetic gene clusters.. 13. 2022
DAXX-ATRX regulation of p53 chromatin binding and DNA damage response.. 13. 2022
Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism.. 13. 2022
Regulation of neuroendocrine plasticity by the RNA-binding protein ZFP36L1.. 13. 2022
Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.. 13. 2022
SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8⁺ T-cells.. 13. 2022
Protection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage.. 13. 2022
Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis.. 13. 2022
Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure.. 13. 2022
Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppression.. 13. 2022
Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts.. 13. 2022
Therapeutic targeting of ATR in alveolar rhabdomyosarcoma.. 13. 2022
A metagenomic DNA sequencing assay that is robust against environmental DNA contamination.. 13. 2022
AMEERA-1 phase 1/2 study of amcenestrant, SAR439859, in postmenopausal women with ER-positive/HER2-negative advanced breast cancer.. 13. 2022
Structures of β₁-adrenergic receptor in complex with Gs and ligands of different efficacies.. 13. 2022
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera.. 13. 2022
TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis.. 13. 2022
Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma.. 13. 2022
Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.. 13. 2022
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets.. 13. 2022
Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes.. 13. 2022
Sex-specific multi-level 3D genome dynamics in the mouse brain.. 13. 2022
CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes.. 13. 2022
Viral coinfection promotes tuberculosis immunopathogenesis by type I IFN signaling-dependent impediment of Th1 cell pulmonary influx.. 13. 2022
Unraveling function and diversity of bacterial lectins in the human microbiome.. 13. 2022
Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar.. 13. 2022
Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers.. 13. 2022
MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets.. 13. 2022
TMEM16 scramblases thin the membrane to enable lipid scrambling.. 13. 2022
Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer.. 13. 2022
Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia.. 13. 2022
Structural insights into TRPV2 activation by small molecules.. 13. 2022
Targeting CD123 in blastic plasmacytoid dendritic cell neoplasm using allogeneic anti-CD123 CAR T cells.. 13. 2022
A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis.. 13. 2022
CinA mediates multidrug tolerance in Mycobacterium tuberculosis.. 13. 2022
Snf7 spirals sense and alter membrane curvature.. 13. 2022
Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model.. 13. 2022
Genomic and transcriptomic analysis of a library of small cell lung cancer patient-derived xenografts.. 13. 2022
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy.. 13. 2022
Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma.. 13. 2022
Predictive biomarkers for survival benefit with ramucirumab in urothelial cancer in the RANGE trial.. 13. 2022
Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics.. 13. 2022
Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression.. 13. 2022
The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers.. 13. 2022
Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer.. 13. 2022
Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology.. 13. 2022
Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis.. 13. 2022
Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance.. 13. 2022
Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.. 13. 2022
Live-dead assay on unlabeled cells using phase imaging with computational specificity.. 13. 2022
Relative infectiousness of SARS-CoV-2 vaccine breakthrough infections, reinfections, and primary infections.. 13. 2022
Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration.. 13. 2022
Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation.. 13. 2022
Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer's disease.. 13. 2022
Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract.. 13. 2022
Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition.. 13. 2022
The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer.. 12. 2021
Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis.. 12. 2021
Single molecule kinetics of bacteriorhodopsin by HS-AFM.. 12. 2021
Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights.. 12. 2021
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury.. 12. 2021
The genetic architecture of DNA replication timing in human pluripotent stem cells.. 12. 2021
G3BP1 inhibits Cul3^SPOP to amplify AR signaling and promote prostate cancer.. 12. 2021
HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway.. 12. 2021
Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection.. 12. 2021
Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties.. 12. 2021
Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.. 12. 2021
Nuclear S-nitrosylation impacts tissue regeneration in zebrafish.. 12. 2021
Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface.. 12. 2021
Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus.. 12. 2021
Clonal hematopoiesis is associated with risk of severe Covid-19.. 12. 2021
Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes.. 12. 2021
Truly privacy-preserving federated analytics for precision medicine with multiparty homomorphic encryption.. 12. 2021
Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer.. 12. 2021
Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice.. 12. 2021
DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation.. 12. 2021
Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression.. 12. 2021
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.. 12. 2021
Metabolic requirements of NK cells during the acute response against retroviral infection.. 12. 2021
β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture.. 12. 2021
Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia.. 12. 2021
The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice.. 12. 2021
Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers.. 12. 2021
Heritability and interindividual variability of regional structure-function coupling.. 12. 2021
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.. 12. 2021
Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice.. 12. 2021
Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM.. 12. 2021
Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10.. 12. 2021
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system.. 12. 2021
Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion.. 12. 2021
SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts.. 12. 2021
Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis.. 12. 2021
3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine.. 12. 2021
Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data.. 12. 2021
Correlation of membrane protein conformational and functional dynamics.. 12. 2021
Ramp-to-threshold dynamics in a hindbrain population controls the timing of spontaneous saccades.. 12. 2021
DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.. 12. 2021
Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS.. 12. 2021
Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection.. 12. 2021
Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice.. 12. 2021
Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission.. 12. 2021
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2.. 12. 2021
Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer.. 12. 2021
Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues.. 12. 2021
Mining mutation contexts across the cancer genome to map tumor site of origin.. 12. 2021
Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility.. 12. 2021
Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators.. 12. 2021
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ.. 12. 2021
Hierarchical progressive learning of cell identities in single-cell data.. 12. 2021
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.. 12. 2021
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.. 12. 2021
Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging.. 12. 2021
Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.. 12. 2021
Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction.. 12. 2021
Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions.. 12. 2021
Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19.. 12. 2021
Revealing the role of the human blood plasma proteome in obesity using genetic drivers.. 12. 2021
Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits.. 12. 2021
Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis.. 12. 2021
Patient-derived xenografts and organoids model therapy response in prostate cancer.. 12. 2021
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers.. 12. 2021
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.. 12. 2021
Chromatin accessibility of circulating CD8⁺ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer.. 12. 2021
Mutant-selective degradation by BRAF-targeting PROTACs.. 12. 2021
Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes.. 12. 2021
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide.. 12. 2021
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma.. 12. 2021
Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors.. 12. 2021
Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification.. 12. 2021
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain.. 12. 2021
Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis.. 12. 2021
HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA).. 12. 2021
Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.. 12. 2021
Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel.. 11. 2020
Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages.. 11. 2020
Phase imaging with computational specificity (PICS) for measuring dry mass changes in sub-cellular compartments.. 11. 2020
Common germline-somatic variant interactions in advanced urothelial cancer.. 11. 2020
CD103⁺ cDC1 and endogenous CD8⁺ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function.. 11. 2020
Direct RNA sequencing reveals m⁶A modifications on adenovirus RNA are necessary for efficient splicing.. 11. 2020
Training confounder-free deep learning models for medical applications.. 11. 2020
Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9.. 11. 2020
Transient commensal clonal interactions can drive tumor metastasis.. 11. 2020
MEKK2 mediates aberrant ERK activation in neurofibromatosis type I.. 11. 2020
A circular RNA generated from an intron of the insulin gene controls insulin secretion.. 11. 2020
Broad genic repression domains signify enhanced silencing of oncogenes.. 11. 2020
Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread.. 11. 2020
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity.. 11. 2020
Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity.. 11. 2020
Prevalent and sex-biased breathing patterns modify functional connectivity MRI in young adults.. 11. 2020
A strategy to incorporate prior knowledge into correlation network cutoff selection.. 11. 2020
Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations.. 11. 2020
The hierarchical assembly of septins revealed by high-speed AFM.. 11. 2020
Millisecond dynamics of an unlabeled amino acid transporter.. 11. 2020
Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma.. 11. 2020
T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration.. 11. 2020
A shared genetic contribution to breast cancer and schizophrenia.. 11. 2020
Prior knowledge promotes hippocampal separation but cortical assimilation in the left inferior frontal gyrus.. 11. 2020
Enhancing mucosal immunity by transient microbiota depletion.. 11. 2020
Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C.. 11. 2020
A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response.. 11. 2020
An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.. 11. 2020
Clearance of HIV infection by selective elimination of host cells capable of producing HIV.. 11. 2020
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine.. 11. 2020
Escape from nonsense-mediated decay associates with anti-tumor immunogenicity.. 11. 2020
Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer.. 11. 2020
Accelerated single cell seeding in relapsed multiple myeloma.. 11. 2020
ITLN1 modulates invasive potential and metabolic reprogramming of ovarian cancer cells in omental microenvironment.. 11. 2020
Mnemonic prediction errors bias hippocampal states.. 11. 2020
ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages.. 11. 2020
Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant.. 11. 2020
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity.. 11. 2020
Machine learning uncovers cell identity regulator by histone code.. 11. 2020
Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers.. 11. 2020
FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth.. 11. 2020
DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis.. 11. 2020
Protein-altering germline mutations implicate novel genes related to lung cancer development.. 11. 2020
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.. 11. 2020
Negative elongation factor complex enables macrophage inflammatory responses by controlling anti-inflammatory gene expression.. 11. 2020
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.. 11. 2020
Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues.. 11. 2020
HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells.. 11. 2020
Integrative multiplatform molecular profiling of benign prostatic hyperplasia identifies distinct subtypes.. 11. 2020
Modeling biological and genetic diversity in upper tract urothelial carcinoma with patient derived xenografts.. 11. 2020
Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis.. 11. 2020
Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics.. 11. 2020
Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction.. 11. 2020
Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability.. 11. 2020
Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome.. 11. 2020
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release.. 11. 2020
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.. 11. 2020
Combined burden and functional impact tests for cancer driver discovery using DriverPower.. 11. 2020
Genomic footprints of activated telomere maintenance mechanisms in cancer.. 11. 2020
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations.. 11. 2020
Integrative pathway enrichment analysis of multivariate omics data.. 11. 2020
Pathway and network analysis of more than 2500 whole cancer genomes.. 11. 2020
Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF.. 11. 2020
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.. 11. 2020
Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements.. 11. 2020
Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms.. 11. 2020
Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer.. 11. 2020
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.. 11. 2020
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction.. 11. 2020
Annexin-V stabilizes membrane defects by inducing lipid phase transition.. 11. 2020
BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins.. 11. 2020
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.. 11. 2020
ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages 2020
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection.. 10. 2019
Molecular determinants of nephron vascular specialization in the kidney.. 10. 2019
Short-term availability of adult-born neurons for memory encoding.. 10. 2019
Conformational pathway provides unique sensitivity to a synaptic mGluR.. 10. 2019
Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection.. 10. 2019
Using somatic variant richness to mine signals from rare variants in the cancer genome.. 10. 2019
A Bayesian machine learning approach for drug target identification using diverse data types.. 10. 2019
Mapping the perturbome network of cellular perturbations.. 10. 2019
Antibody cross-reactivity accounts for widespread appearance of m¹A in 5'UTRs.. 10. 2019
Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca²⁺-bound nhTMEM16.. 10. 2019
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development.. 10. 2019
Colonizing multidrug-resistant bacteria and the longitudinal evolution of the intestinal microbiome after liver transplantation.. 10. 2019
Engineering transferrable microvascular meshes for subcutaneous islet transplantation.. 10. 2019
Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23.. 10. 2019
Urothelial organoids originating from Cd49f^high mouse stem cells display Notch-dependent differentiation capacity.. 10. 2019
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program.. 10. 2019
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle.. 10. 2019
Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells.. 10. 2019
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.. 10. 2019
Accurate detection of m⁶A RNA modifications in native RNA sequences.. 10. 2019
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.. 10. 2019
Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences.. 10. 2019
Wilm's tumor 1 promotes memory flexibility.. 10. 2019
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis.. 10. 2019
IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation.. 10. 2019
Non-coding variability at the APOE locus contributes to the Alzheimer's risk.. 10. 2019
Alternative splicing regulates stochastic NLRP3 activity.. 10. 2019
Predictive metabolomic profiling of microbial communities using amplicon or metagenomic sequences.. 10. 2019
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling.. 10. 2019
Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis.. 10. 2019
Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents.. 10. 2019
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.. 10. 2019
Chromatin organization in the female mouse brain fluctuates across the oestrous cycle.. 10. 2019
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases.. 10. 2019
HIV-1 DNA sequence diversity and evolution during acute subtype C infection.. 10. 2019
Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation.. 10. 2019
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.. 10. 2019
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence.. 10. 2019
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus.. 10. 2019
Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease.. 10. 2019
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL.. 10. 2019
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.. 10. 2019
Microtubule end conversion mediated by motors and diffusing proteins with no intrinsic microtubule end-binding activity.. 10. 2019
Breast cancer quantitative proteome and proteogenomic landscape.. 10. 2019
Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer.. 10. 2019
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.. 10. 2019
Reversible histone glycation is associated with disease-related changes in chromatin architecture.. 10. 2019
Restoration of high-sensitivity and adapting vision with a cone opsin.. 10. 2019
Flagellar cAMP signaling controls trypanosome progression through host tissues.. 10. 2019
Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response.. 10. 2019
Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide.. 10. 2019
Longitudinal HIV sequencing reveals reservoir expression leading to decay which is obscured by clonal expansion.. 10. 2019
Intestinal non-canonical NFκB signaling shapes the local and systemic immune response.. 10. 2019
Single-molecule sequencing detection of N6-methyladenine in microbial reference materials.. 10. 2019
ONECUT2 is a driver of neuroendocrine prostate cancer.. 10. 2019
The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors.. 10. 2019
Enhanced astrocyte responses are driven by a genetic risk allele associated with multiple sclerosis.. 9. 2018
Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy.. 9. 2018
High-speed AFM height spectroscopy reveals µs-dynamics of unlabeled biomolecules.. 9. 2018
Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment.. 9. 2018
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival.. 9. 2018
Inflammation-induced Id2 promotes plasticity in regulatory T cells.. 9. 2018
Human antibodies targeting Zika virus NS1 provide protection against disease in a mouse model.. 9. 2018
Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics.. 9. 2018
Testicular endothelial cells are a critical population in the germline stem cell niche.. 9. 2018
ZZ-dependent regulation of p62/SQSTM1 in autophagy.. 9. 2018
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons.. 9. 2018
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference.. 9. 2018
A missense variant in SLC39A8 is associated with severe idiopathic scoliosis.. 9. 2018
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism.. 9. 2018
Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer.. 9. 2018
Bone protection by inhibition of microRNA-182.. 9. 2018
An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel.. 9. 2018
Genus-wide sequencing supports a two-locus model for sex-determination in Phoenix.. 9. 2018
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones.. 9. 2018
Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function.. 9. 2018
The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice.. 9. 2018
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis.. 9. 2018
Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses.. 9. 2018
Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumors.. 9. 2018
Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.. 9. 2018
Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase.. 9. 2018
Recurrent homozygous deletion of DROSHA and microduplication of PDE4DIP in pineoblastoma.. 9. 2018
Simplified ChIP-exo assays.. 9. 2018
PRMT5-mediated regulation of developmental myelination.. 9. 2018
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b.. 9. 2018
Discovery of a drug candidate for GLIS3-associated diabetes.. 9. 2018
Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease.. 9. 2018
Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract.. 9. 2018
Patient derived organoids to model rare prostate cancer phenotypes.. 9. 2018
Helicase promotes replication re-initiation from an RNA transcript.. 9. 2018
Finding influential nodes for integration in brain networks using optimal percolation theory.. 9. 2018
Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces.. 9. 2018
Male germ cells support long-term propagation of Zika virus.. 9. 2018
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models.. 9. 2018
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas.. 9. 2018
Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma.. 9. 2018
Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer.. 9. 2018
Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28.. 9. 2018
Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models.. 9. 2018
Increased formate overflow is a hallmark of oxidative cancer.. 9. 2018
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.. 9. 2018
Improving genetic prediction by leveraging genetic correlations among human diseases and traits.. 9. 2018
Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer.. 9. 2018
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.. 9. 2018
Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation.. 9. 2018
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy.. 9. 2018
Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.. 9. 2018
Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models.. 9. 2018
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α.. 9. 2018
Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1.. 9. 2018
Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population.. 9. 2018
A general and flexible method for signal extraction from single-cell RNA-seq data.. 9. 2018
A partially-open inward-facing intermediate conformation of LeuT is associated with Na⁺ release and substrate transport.. 9. 2018
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.. 9. 2018
Target engagement imaging of PARP inhibitors in small-cell lung cancer.. 9. 2018
Peptidomimetic blockade of MYB in acute myeloid leukemia.. 9. 2018
Weakly perturbative imaging of interfacial water with submolecular resolution by atomic force microscopy.. 9. 2018
Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5.. 9. 2018
Improved split fluorescent proteins for endogenous protein labeling. 8:1-11. 2018
Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer.. 8. 2017
The evolutionary landscape of chronic lymphocytic leukemia treated with ibrutinib targeted therapy.. 8. 2017
EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer.. 8. 2017
Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor.. 8. 2017
Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages.. 8. 2017
Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.. 8. 2017
Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.. 8. 2017
Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway.. 8. 2017
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology.. 8. 2017
mTOR intersects antibody-inducing signals from TACI in marginal zone B cells.. 8. 2017
Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.. 8. 2017
Resistance to checkpoint blockade therapy through inactivation of antigen presentation.. 8. 2017
Deletion of 3p13-14 locus spanning FOXP1 to SHQ1 cooperates with PTEN loss in prostate oncogenesis.. 8. 2017
Ets transcription factor GABP controls T cell homeostasis and immunity.. 8. 2017
The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.. 8. 2017
TRIM29 promotes DNA virus infections by inhibiting innate immune response.. 8. 2017
Deciphering TAL effectors for 5-methylcytosine and 5-hydroxymethylcytosine recognition.. 8. 2017
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.. 8. 2017
An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses.. 8. 2017
Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes.. 8. 2017
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice.. 8. 2017
A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice.. 8. 2017
Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer.. 8. 2017
ATRX is a regulator of therapy induced senescence in human cells.. 8. 2017
ROCKII inhibition promotes the maturation of human pancreatic beta-like cells.. 8. 2017
Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit.. 8. 2017
The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity.. 8. 2017
Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells.. 8. 2017
Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.. 8. 2017
Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy.. 8. 2017
Transancestral mapping and genetic load in systemic lupus erythematosus.. 8. 2017
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.. 8. 2017
Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.. 8. 2017
Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis.. 8. 2017
The m⁶A pathway facilitates sex determination in Drosophila.. 8. 2017
Inherited determinants of early recurrent somatic mutations in prostate cancer.. 8. 2017
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity.. 8. 2017
Correspondence: DNA shape is insufficient to explain binding.. 8. 2017
Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.. 8. 2017
Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations.. 8. 2017
Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors.. 8. 2017
ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.. 8. 2017
An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data.. 8. 2017
The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility.. 8. 2017
A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages.. 8. 2017
Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death.. 8. 2017
An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells.. 8. 2017
Connecting genetic risk to disease end points through the human blood plasma proteome.. 8. 2017
Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits.. 8. 2017
Rapid and tunable method to temporally control gene editing based on conditional Cas9 stabilization.. 8. 2017
SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts.. 8. 2017
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity.. 8. 2017
Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma.. 8. 2017
Topical tacrolimus for the treatment of secondary lymphedema.. 8. 2017
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.. 8. 2017
THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors.. 8. 2017
Sox17 drives functional engraftment of endothelium converted from non-vascular cells.. 8. 2017
Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.. 7. 2016
Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire.. 7. 2016
DNA looping mediates nucleosome transfer.. 7. 2016
Increased global transcription activity as a mechanism of replication stress in cancer.. 7. 2016
Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets.. 7. 2016
Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.. 7. 2016
FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase.. 7. 2016
Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels.. 7. 2016
Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.. 7. 2016
ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival.. 7. 2016
TP53 mutations emerge with HDM2 inhibitor SAR405838 treatment in de-differentiated liposarcoma.. 7. 2016
Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells.. 7. 2016
PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis.. 7. 2016
Deconvoluting hepatic processing of carbon nanotubes.. 7. 2016
Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal.. 7. 2016
The transcriptional coregulator GRIP1 controls macrophage polarization and metabolic homeostasis.. 7. 2016
Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus.. 7. 2016
A rhesus macaque model of Asian-lineage Zika virus infection.. 7. 2016
miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy.. 7. 2016
Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis.. 7. 2016
Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy.. 7. 2016
Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics.. 7. 2016
Simultaneous optical and electrical in vivo analysis of the enteric nervous system.. 7. 2016
A method to rapidly create protein aggregates in living cells.. 7. 2016
Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories.. 7. 2016
The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells.. 7. 2016
Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms.. 7. 2016
Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation.. 7. 2016
Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease.. 7. 2016
Laminin regulates PDGFRβ(+) cell stemness and muscle development.. 7. 2016
Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells.. 7. 2016
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.. 7. 2016
Augmenting drug-carrier compatibility improves tumour nanotherapy efficacy.. 7. 2016
Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis.. 7. 2016
The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures.. 7. 2016
FAT1 mutations cause a glomerulotubular nephropathy.. 7. 2016
MSI2 is required for maintaining activated myelodysplastic syndrome stem cells.. 7. 2016
Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer.. 7. 2016
Genome-wide association and high-resolution phenotyping link Oryza sativa panicle traits to numerous trait-specific QTL clusters.. 7. 2016
Microbial metabolomics in open microscale platforms.. 7. 2016
Open access resources for genome-wide association mapping in rice.. 7. 2016
Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius.. 7. 2016
Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis.. 7. 2016
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile.. 7. 2016
Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish.. 7. 2016
Bcl-xL promotes metastasis independent of its anti-apoptotic activity.. 7. 2016
CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking.. 7. 2016
T7 replisome directly overcomes DNA damage.. 6. 2015
miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity.. 6. 2015
Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma.. 6. 2015
Whole genome re-sequencing of date palms yields insights into diversification of a fruit tree crop.. 6. 2015
Formation of functional super-helical assemblies by constrained single heptad repeat.. 6. 2015
Genomic analyses reveal recurrent mutations in epigenetic modifiers and the JAK-STAT pathway in Sézary syndrome.. 6. 2015
Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike.. 6. 2015
Calcium ions open a selectivity filter gate during activation of the MthK potassium channel.. 6. 2015
Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA.. 6. 2015
GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation.. 6. 2015
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.. 6. 2015
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke.. 6. 2015
Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions.. 6. 2015
PTEN regulates DNA replication progression and stalled fork recovery.. 6. 2015
IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection.. 6. 2015
Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.. 6. 2015
Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization.. 6. 2015
Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE.. 6. 2015
FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization.. 6. 2015
Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation.. 6. 2015
Coupled local translation and degradation regulate growth cone collapse.. 6. 2015
Epigenomic evolution in diffuse large B-cell lymphomas.. 6. 2015
miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β.. 6. 2015
Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy.. 6. 2015
ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype.. 6. 2015
RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.. 6. 2015
Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia.. 6. 2015
FAAH genetic variation enhances fronto-amygdala function in mouse and human.. 6. 2015
Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity.. 6. 2015
Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env.. 6. 2015
Numerical chromosomal instability mediates susceptibility to radiation treatment.. 6. 2015
Annexin A2 promotes phagophore assembly by enhancing Atg16L⁺ vesicle biogenesis and homotypic fusion.. 6. 2015
Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery.. 6. 2015
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.. 6. 2015
CCR7-dependent trafficking of RORγ⁺ ILCs creates a unique microenvironment within mucosal draining lymph nodes.. 6. 2015
A genome-wide association study of marginal zone lymphoma shows association to the HLA region.. 6. 2015
Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2-MALT1 in MALT lymphoma.. 6. 2015
The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch.. 5. 2014
ERG induces taxane resistance in castration-resistant prostate cancer.. 5. 2014
Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin.. 5. 2014
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer.. 5. 2014
The K526R substitution in viral protein PB2 enhances the effects of E627K on influenza virus replication.. 5. 2014
Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation.. 5. 2014
Ostwald's rule of stages governs structural transitions and morphology of dipeptide supramolecular polymers.. 5. 2014
Microwave purification of large-area horizontally aligned arrays of single-walled carbon nanotubes.. 5. 2014
The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction.. 5. 2014
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.. 5. 2014
Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines.. 5. 2014
An authentic imaging probe to track cell fate from beginning to end.. 5. 2014
Constitutive phospholipid scramblase activity of a G protein-coupled receptor.. 5. 2014
Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment.. 5. 2014
Assessing technical performance in differential gene expression experiments with external spike-in RNA control ratio mixtures.. 5. 2014
Activation of diverse signalling pathways by oncogenic PIK3CA mutations.. 5. 2014
Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.. 5. 2014
Membrane curvature sensing by the C-terminal domain of complexin.. 5. 2014
Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.. 5. 2014
Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming.. 5. 2014
Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression.. 5. 2014
Direct induction of haematoendothelial programs in human pluripotent stem cells by transcriptional regulators.. 5. 2014
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.. 5. 2014
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity.. 5. 2014
Sema3E/PlexinD1 regulates the migration of hem-derived Cajal-Retzius cells in developing cerebral cortex.. 5. 2014
p38 MAPK-inhibited dendritic cells induce superior antitumour immune responses and overcome regulatory T-cell-mediated immunosuppression.. 5. 2014
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel.. 5. 2014
The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism.. 5. 2014
Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells.. 5. 2014
Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma.. 5. 2014
Mid-range Ca2+ signalling mediated by functional coupling between store-operated Ca2+ entry and IP3-dependent Ca2+ release.. 5. 2014
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration.. 5. 2014
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids.. 5. 2014
MTSS1 is a metastasis driver in a subset of human melanomas.. 5. 2014
2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity.. 5. 2014
Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching.. 5. 2014
A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages.. 5. 2014
Acquisition of innate-like microbial reactivity in mucosal tissues during human fetal MAIT-cell development.. 5. 2014
Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon.. 5. 2014
Kinase fusions are frequent in Spitz tumours and spitzoid melanomas.. 5. 2014
Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.. 5. 2014
Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle.. 5. 2014
microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition.. 5. 2014
A hybrid high-speed atomic force-optical microscope for visualizing single membrane proteins on eukaryotic cells.. 4. 2013
Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel.. 4. 2013
Dimensionality of brain networks linked to life-long individual differences in self-control.. 4. 2013
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.. 4. 2013
Equilibrium selectivity alone does not create K+-selective ion conduction in K+ channels.. 4. 2013
Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation.. 4. 2013
Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.. 4. 2013
InVERT molding for scalable control of tissue microarchitecture.. 4. 2013
RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription.. 4. 2013
Torque modulates nucleosome stability and facilitates H2A/H2B dimer loss.. 4. 2013
Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction.. 4. 2013
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression.. 3. 2012
Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris.. 3. 2012
Evidence of an inhibitory restraint of seizure activity in humans.. 3. 2012
Multiplexed volumetric bar-chart chip for point-of-care diagnostics.. 3. 2012
Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa.. 2. 2011
Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling.. 2. 2011
Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17.. 2. 2011
Structure and Scm3-mediated assembly of budding yeast centromeric nucleosomes.. 2. 2011
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells.. 2. 2011
Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation.. 2. 2011
A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.. 1. 2010
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy.. 1. 2010
Reply to: Limitations of molecular testing in combination with computerized tomographic for lung cancer screening. 2022
Protective alleles and precision healthcare in crewed spaceflight. 2024
Astronaut omics and the impact of space on the human body at scale. 2024
Ethical considerations for the age of non-governmental space exploration. 2024
The genetic architecture of membranous nephropathy and its potential to improve non-invasive diagnosis. 2020

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