Nature communications
Journal
Overview
publication venue for
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Author Correction: ChromaFold predicts the 3D contact map from single-cell chromatin accessibility.
2025
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Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial.
2024
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Author Correction: A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus.
2023
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Publisher Correction: Epigenetic landscape reveals MECOM as an endothelial lineage regulator.
2023
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Author Correction: A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma.
2023
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Author Correction: Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure.
2022
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Author Correction: Truly privacy-preserving federated analytics for precision medicine with multiparty homomorphic encryption.
2021
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Publisher Correction: Mnemonic prediction errors bias hippocampal states.
2020
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Publisher Correction: ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression.
2019
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Author Correction: An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses.
2018
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Publisher Correction: Finding influential nodes for integration in brain networks using optimal percolation theory.
2018
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Corrigendum: A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages.
2017
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SARS-CoV-2 induced immune perturbations in infants vary with disease severity and differ from adults' responses..
16.
2025
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Sex-specific perturbations of neuronal development caused by mutations in the autism risk gene DDX3X..
16.
2025
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Structural dynamics and permeability of the TRPV3 pentamer..
16.
2025
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Multicenter target trial emulation to evaluate corticosteroids for sepsis stratified by predicted organ dysfunction trajectory..
16.
2025
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Identification of predictive subphenotypes for clinical outcomes using real world data and machine learning..
16.
2025
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A minimally invasive thrombotic model to study stroke in awake mice..
16.
2025
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Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy..
16.
2025
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Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE..
16.
2025
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Structural insights into terminal arabinosylation of mycobacterial cell wall arabinan..
16.
2025
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MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer..
16.
2025
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Long COVID after SARS-CoV-2 during pregnancy in the United States..
16.
2025
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Astrocyte-secreted cues promote neural maturation and augment activity in human forebrain organoids..
16.
2025
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Direct measurement of the male germline mutation rate in individuals using sequential sperm samples..
16.
2025
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Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases..
16.
2025
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Individual bioenergetic capacity as a potential source of resilience to Alzheimer's disease..
16.
2025
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Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel..
16.
2025
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A structural biology compatible file format for atomic force microscopy..
16.
2025
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Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes..
16.
2025
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Testosterone exacerbates neutrophilia and cardiac injury in myocardial infarction via actions in bone marrow..
16.
2025
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Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex..
16.
2025
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Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes..
16.
2025
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Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice..
16.
2025
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Altered mitochondria-associated ER membrane (MAM) function shifts mitochondrial metabolism in amyotrophic lateral sclerosis (ALS)..
16.
2025
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Deeper response predicts better outcomes in high-risk-smoldering-myeloma: results of the I-PRISM phase II clinical trial..
16.
2025
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STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration..
16.
2025
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Rapid nongenomic estrogen signaling controls alcohol drinking behavior in mice..
15.
2024
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Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate..
15.
2024
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Neuronal diversity and stereotypy at multiple scales through whole brain morphometry..
15.
2024
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Deep generative AI models analyzing circulating orphan non-coding RNAs enable detection of early-stage lung cancer..
15.
2024
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Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer..
15.
2024
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Harnessing the regenerative potential of interleukin11 to enhance heart repair..
15.
2024
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ChromaFold predicts the 3D contact map from single-cell chromatin accessibility..
15.
2024
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Uncoupling of mTORC1 from E2F activity maintains DNA damage and senescence..
15.
2024
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Mechanisms of epigenomic and functional convergence between glucocorticoid- and IL4-driven macrophage programming..
15.
2024
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Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome..
15.
2024
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Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice..
15.
2024
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Strengthening and expanding capacities in clinical trials: advancing pandemic prevention, preparedness and response in Africa..
15.
2024
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Towards geospatially-resolved public-health surveillance via wastewater sequencing..
15.
2024
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PIP2 inhibits pore opening of the cyclic nucleotide-gated channel SthK..
15.
2024
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Emergence of transmissible SARS-CoV-2 variants with decreased sensitivity to antivirals in immunocompromised patients with persistent infections..
15.
2024
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Automatic ploidy prediction and quality assessment of human blastocysts using time-lapse imaging..
15.
2024
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Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2..
15.
2024
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Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue..
15.
2024
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A roadmap to the molecular human linking multiomics with population traits and diabetes subtypes..
15.
2024
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Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion..
15.
2024
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Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization..
15.
2024
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Mutant mice with rod-specific VPS35 deletion exhibit retinal α-synuclein pathology-associated degeneration..
15.
2024
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Combined inhibition of KRASG12C and mTORC1 kinase is synergistic in non-small cell lung cancer..
15.
2024
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HIV-1 subtype A1, D, and recombinant proviral genome landscapes during long-term suppressive therapy..
15.
2024
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DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility..
15.
2024
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Structural basis for hyperpolarization-dependent opening of human HCN1 channel..
15.
2024
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Low potassium activation of proximal mTOR/AKT signaling is mediated by Kir4.2..
15.
2024
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Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium..
15.
2024
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Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)..
15.
2024
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Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction..
15.
2024
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Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses..
15.
2024
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Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight..
15.
2024
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Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight..
15.
2024
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Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight..
15.
2024
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Space radiation damage rescued by inhibition of key spaceflight associated miRNAs..
15.
2024
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Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight..
15.
2024
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Spatiotemporal expression and control of haemoglobin in space..
15.
2024
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Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels..
15.
2024
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The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis..
15.
2024
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Integrating human endogenous retroviruses into transcriptome-wide association studies highlights novel risk factors for major psychiatric conditions..
15.
2024
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Mycobacterial biotin synthases require an auxiliary protein to convert dethiobiotin into biotin..
15.
2024
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Determinants of mosaic chromosomal alteration fitness..
15.
2024
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A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin..
15.
2024
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Salmonella exploits membrane reservoirs for invasion of host cells..
15.
2024
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Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment..
15.
2024
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SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration..
15.
2024
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A fast-acting lipid checkpoint in G1 prevents mitotic defects..
15.
2024
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The evolution of metastatic upper tract urothelial carcinoma through genomic-transcriptomic and single-cell protein markers analysis..
15.
2024
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Biallelic NAA60 variants with impaired n-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications..
15.
2024
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FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease..
15.
2024
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TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection..
15.
2024
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Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders..
15.
2024
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Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover..
15.
2024
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Molecular basis of VEGFR1 autoinhibition at the plasma membrane..
15.
2024
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A phase 1/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome..
15.
2024
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Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase..
15.
2024
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Structure of the M. tuberculosis DnaK-GrpE complex reveals how key DnaK roles are controlled..
15.
2024
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HHV-6B detection and host gene expression implicate HHV-6B as pulmonary pathogen after hematopoietic cell transplant..
15.
2024
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Distinct mesenchymal cell states mediate prostate cancer progression..
15.
2024
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Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial..
14.
2023
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Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis..
14.
2023
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Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors..
14.
2023
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Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis..
14.
2023
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High-throughput target trial emulation for Alzheimer's disease drug repurposing with real-world data..
14.
2023
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Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase..
14.
2023
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Young infants display heterogeneous serological responses and extensive but reversible transcriptional changes following initial immunizations..
14.
2023
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Label-free identification of protein aggregates using deep learning..
14.
2023
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Clinically relevant antibiotic resistance genes are linked to a limited set of taxa within gut microbiome worldwide..
14.
2023
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Enhanced clinical assessment of hematologic malignancies through routine paired tumor and normal sequencing..
14.
2023
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A concerted ATPase cycle of the protein transporter AAA-ATPase Bcs1..
14.
2023
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Improving model fairness in image-based computer-aided diagnosis..
14.
2023
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THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer..
14.
2023
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Epitranscriptomic subtyping, visualization, and denoising by global motif visualization..
14.
2023
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Divergent single cell transcriptome and epigenome alterations in ALS and FTD patients with C9orf72 mutation..
14.
2023
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A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury..
14.
2023
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Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumors..
14.
2023
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Structural basis of peptidoglycan synthesis by E. coli RodA-PBP2 complex..
14.
2023
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A biallelic multiple nucleotide length polymorphism explains functional causality at 5p15.33 prostate cancer risk locus..
14.
2023
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SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates..
14.
2023
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Structural basis of agonist specificity of α1A-adrenergic receptor..
14.
2023
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MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation..
14.
2023
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Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry..
14.
2023
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Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates..
14.
2023
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A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable pancreatic adenocarcinoma..
14.
2023
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Targeted viral adaptation generates a simian-tropic hepatitis B virus that infects marmoset cells..
14.
2023
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A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8..
14.
2023
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Vaccinia E5 is a major inhibitor of the DNA sensor cGAS..
14.
2023
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Task-specific modulation of corticospinal neuron activity during motor learning in mice..
14.
2023
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Highly host-linked viromes in the built environment possess habitat-dependent diversity and functions for potential virus-host coevolution..
14.
2023
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Symport and antiport mechanisms of human glutamate transporters..
14.
2023
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Regulation of social interaction in mice by a frontostriatal circuit modulated by established hierarchical relationships..
14.
2023
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Epigenetic landscape reveals MECOM as an endothelial lineage regulator..
14.
2023
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Inducible expression of interleukin-12 augments the efficacy of affinity-tuned chimeric antigen receptors in murine solid tumor models..
14.
2023
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Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response..
14.
2023
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Data-driven analysis to understand long COVID using electronic health records from the RECOVER initiative..
14.
2023
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Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance..
14.
2023
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mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs..
14.
2023
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Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1..
14.
2023
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On-demand male contraception via acute inhibition of soluble adenylyl cyclase..
14.
2023
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Antitumour activity of neratinib in patients with HER2-mutant advanced biliary tract cancers..
14.
2023
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Transcriptional reprogramming of skeletal muscle stem cells by the niche environment..
14.
2023
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Epigenomic charting and functional annotation of risk loci in renal cell carcinoma..
14.
2023
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Cytotoxic CD8+ T cells target citrullinated antigens in rheumatoid arthritis..
14.
2023
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Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer..
14.
2023
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Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers..
14.
2023
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Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter's transformation..
14.
2023
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Diverse monogenic subforms of human spermatogenic failure..
13.
2022
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Activation of a transient progenitor state in the epicardium is required for zebrafish heart regeneration..
13.
2022
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Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program..
13.
2022
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Breast cancer prevention by short-term inhibition of TGFβ signaling..
13.
2022
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Backbone amides are determinants of Cl- selectivity in CLC ion channels..
13.
2022
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Membrane-mediated protein interactions drive membrane protein organization..
13.
2022
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mTORC1 links pathology in experimental models of Still's disease and macrophage activation syndrome..
13.
2022
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High-throughput screening of caterpillars as a platform to study host-microbe interactions and enteric immunity..
13.
2022
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Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies..
13.
2022
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Metabolic and proteomic signatures of type 2 diabetes subtypes in an Arab population..
13.
2022
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Gating intermediates reveal inhibitory role of the voltage sensor in a cyclic nucleotide-modulated ion channel..
13.
2022
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Structural basis for mechanotransduction in a potassium-dependent mechanosensitive ion channel..
13.
2022
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Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration..
13.
2022
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A broadly protective human monoclonal antibody targeting the sialidase activity of influenza A and B virus neuraminidases..
13.
2022
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BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling..
13.
2022
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Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression..
13.
2022
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A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma..
13.
2022
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Lysyl-tRNA synthetase, a target for urgently needed M. tuberculosis drugs..
13.
2022
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Regional gene expression signatures are associated with sex-specific functional connectivity changes in depression..
13.
2022
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TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma..
13.
2022
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Modeling tissue-specific breakpoint proximity of structural variations from whole-genomes to identify cancer drivers..
13.
2022
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Batch effects removal for microbiome data via conditional quantile regression..
13.
2022
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In vivo tumor immune microenvironment phenotypes correlate with inflammation and vasculature to predict immunotherapy response..
13.
2022
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Multiplexed mobilization and expression of biosynthetic gene clusters..
13.
2022
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Perforin-2 clockwise hand-over-hand pre-pore to pore transition mechanism..
13.
2022
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Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models..
13.
2022
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SARS CoV-2 mRNA vaccination exposes latent HIV to Nef-specific CD8+ T-cells..
13.
2022
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Protection of Omicron sub-lineage infection against reinfection with another Omicron sub-lineage..
13.
2022
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Distinctive roles of translesion polymerases DinB1 and DnaE2 in diversification of the mycobacterial genome through substitution and frameshift mutagenesis..
13.
2022
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Maladaptive positive feedback production of ChREBPβ underlies glucotoxic β-cell failure..
13.
2022
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Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppression..
13.
2022
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Therapeutic targeting of ATR in alveolar rhabdomyosarcoma..
13.
2022
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A metagenomic DNA sequencing assay that is robust against environmental DNA contamination..
13.
2022
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AMEERA-1 phase 1/2 study of amcenestrant, SAR439859, in postmenopausal women with ER-positive/HER2-negative advanced breast cancer..
13.
2022
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Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies..
13.
2022
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Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera..
13.
2022
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TGFβ reprograms TNF stimulation of macrophages towards a non-canonical pathway driving inflammatory osteoclastogenesis..
13.
2022
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Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma..
13.
2022
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Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma..
13.
2022
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Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets..
13.
2022
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Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes..
13.
2022
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Sex-specific multi-level 3D genome dynamics in the mouse brain..
13.
2022
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CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes..
13.
2022
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Unraveling function and diversity of bacterial lectins in the human microbiome..
13.
2022
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Duration of mRNA vaccine protection against SARS-CoV-2 Omicron BA.1 and BA.2 subvariants in Qatar..
13.
2022
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Feasibility of whole genome and transcriptome profiling in pediatric and young adult cancers..
13.
2022
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MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets..
13.
2022
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TMEM16 scramblases thin the membrane to enable lipid scrambling..
13.
2022
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Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer..
13.
2022
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Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia..
13.
2022
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Structural insights into TRPV2 activation by small molecules..
13.
2022
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A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis..
13.
2022
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CinA mediates multidrug tolerance in Mycobacterium tuberculosis..
13.
2022
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Snf7 spirals sense and alter membrane curvature..
13.
2022
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Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy..
13.
2022
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Neoantigen-specific CD8 T cell responses in the peripheral blood following PD-L1 blockade might predict therapy outcome in metastatic urothelial carcinoma..
13.
2022
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Predictive biomarkers for survival benefit with ramucirumab in urothelial cancer in the RANGE trial..
13.
2022
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Engineering a niche supporting hematopoietic stem cell development using integrated single-cell transcriptomics..
13.
2022
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Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression..
13.
2022
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The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers..
13.
2022
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Co-targeting of BAX and BCL-XL proteins broadly overcomes resistance to apoptosis in cancer..
13.
2022
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Dihydroceramide- and ceramide-profiling provides insights into human cardiometabolic disease etiology..
13.
2022
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Lapcin, a potent dual topoisomerase I/II inhibitor discovered by soil metagenome guided total chemical synthesis..
13.
2022
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Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance..
13.
2022
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Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate..
13.
2022
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Live-dead assay on unlabeled cells using phase imaging with computational specificity..
13.
2022
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Relative infectiousness of SARS-CoV-2 vaccine breakthrough infections, reinfections, and primary infections..
13.
2022
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Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration..
13.
2022
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Postmortem high-dimensional immune profiling of severe COVID-19 patients reveals distinct patterns of immunosuppression and immunoactivation..
13.
2022
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Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract..
13.
2022
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Total energy expenditure is repeatable in adults but not associated with short-term changes in body composition..
13.
2022
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The long noncoding RNA H19 regulates tumor plasticity in neuroendocrine prostate cancer..
12.
2021
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Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis..
12.
2021
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Single molecule kinetics of bacteriorhodopsin by HS-AFM..
12.
2021
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Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights..
12.
2021
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ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury..
12.
2021
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The genetic architecture of DNA replication timing in human pluripotent stem cells..
12.
2021
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G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer..
12.
2021
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HER2 + breast cancers evade anti-HER2 therapy via a switch in driver pathway..
12.
2021
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Multiple acyl-CoA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection..
12.
2021
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Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties..
12.
2021
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Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer..
12.
2021
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Spatially resolved transcriptomics reveals the architecture of the tumor-microenvironment interface..
12.
2021
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Functionality of the putative surface glycoproteins of the Wuhan spiny eel influenza virus..
12.
2021
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Clonal hematopoiesis is associated with risk of severe Covid-19..
12.
2021
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Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes..
12.
2021
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Truly privacy-preserving federated analytics for precision medicine with multiparty homomorphic encryption..
12.
2021
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DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation..
12.
2021
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Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression..
12.
2021
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Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia..
12.
2021
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Metabolic requirements of NK cells during the acute response against retroviral infection..
12.
2021
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Aging, inflammation and DNA damage in the somatic testicular niche with idiopathic germ cell aplasia..
12.
2021
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The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice..
12.
2021
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Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers..
12.
2021
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ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer..
12.
2021
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Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice..
12.
2021
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Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10..
12.
2021
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Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system..
12.
2021
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Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion..
12.
2021
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SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts..
12.
2021
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Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis..
12.
2021
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3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine..
12.
2021
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Development of a fixed module repertoire for the analysis and interpretation of blood transcriptome data..
12.
2021
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Correlation of membrane protein conformational and functional dynamics..
12.
2021
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Enhanced specificity of clinical high-sensitivity tumor mutation profiling in cell-free DNA via paired normal sequencing using MSK-ACCESS..
12.
2021
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Tick extracellular vesicles enable arthropod feeding and promote distinct outcomes of bacterial infection..
12.
2021
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Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice..
12.
2021
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Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission..
12.
2021
-
Clinical CDK4/6 inhibitors induce selective and immediate dissociation of p21 from cyclin D-CDK4 to inhibit CDK2..
12.
2021
-
Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer..
12.
2021
-
Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues..
12.
2021
-
Gene-level metagenomic architectures across diseases yield high-resolution microbiome diagnostic indicators..
12.
2021
-
NBR1 is a critical step in the repression of thermogenesis of p62-deficient adipocytes through PPARγ..
12.
2021
-
Hierarchical progressive learning of cell identities in single-cell data..
12.
2021
-
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice..
12.
2021
-
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12..
12.
2021
-
Learned adaptive multiphoton illumination microscopy for large-scale immune response imaging..
12.
2021
-
Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions..
12.
2021
-
Association between antecedent statin use and decreased mortality in hospitalized patients with COVID-19..
12.
2021
-
Revealing the role of the human blood plasma proteome in obesity using genetic drivers..
12.
2021
-
Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits..
12.
2021
-
Gastrointestinal microbiota composition predicts peripheral inflammatory state during treatment of human tuberculosis..
12.
2021
-
Patient-derived xenografts and organoids model therapy response in prostate cancer..
12.
2021
-
A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers..
12.
2021
-
ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism..
12.
2021
-
Chromatin accessibility of circulating CD8+ T cells predicts treatment response to PD-1 blockade in patients with gastric cancer..
12.
2021
-
Mutant-selective degradation by BRAF-targeting PROTACs..
12.
2021
-
Integrative molecular characterization of sarcomatoid and rhabdoid renal cell carcinoma..
12.
2021
-
Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors..
12.
2021
-
Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification..
12.
2021
-
A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain..
12.
2021
-
Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis..
12.
2021
-
HIV-1 diversity considerations in the application of the Intact Proviral DNA Assay (IPDA)..
12.
2021
-
Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel..
11.
2020
-
Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages..
11.
2020
-
Phase imaging with computational specificity (PICS) for measuring dry mass changes in sub-cellular compartments..
11.
2020
-
Common germline-somatic variant interactions in advanced urothelial cancer..
11.
2020
-
CD103+ cDC1 and endogenous CD8+ T cells are necessary for improved CD40L-overexpressing CAR T cell antitumor function..
11.
2020
-
Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing..
11.
2020
-
MEKK2 mediates aberrant ERK activation in neurofibromatosis type I..
11.
2020
-
Revealing fine-scale spatiotemporal differences in SARS-CoV-2 introduction and spread..
11.
2020
-
Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity..
11.
2020
-
Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity..
11.
2020
-
Prevalent and sex-biased breathing patterns modify functional connectivity MRI in young adults..
11.
2020
-
A strategy to incorporate prior knowledge into correlation network cutoff selection..
11.
2020
-
Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations..
11.
2020
-
The hierarchical assembly of septins revealed by high-speed AFM..
11.
2020
-
Millisecond dynamics of an unlabeled amino acid transporter..
11.
2020
-
T-Plastin reinforces membrane protrusions to bridge matrix gaps during cell migration..
11.
2020
-
A shared genetic contribution to breast cancer and schizophrenia..
11.
2020
-
Prior knowledge promotes hippocampal separation but cortical assimilation in the left inferior frontal gyrus..
11.
2020
-
An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution..
11.
2020
-
Clearance of HIV infection by selective elimination of host cells capable of producing HIV..
11.
2020
-
Blockade of the AHR restricts a Treg-macrophage suppressive axis induced by L-Kynurenine..
11.
2020
-
Escape from nonsense-mediated decay associates with anti-tumor immunogenicity..
11.
2020
-
Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer..
11.
2020
-
Accelerated single cell seeding in relapsed multiple myeloma..
11.
2020
-
Mnemonic prediction errors bias hippocampal states..
11.
2020
-
Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant..
11.
2020
-
Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity..
11.
2020
-
Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers..
11.
2020
-
Protein-altering germline mutations implicate novel genes related to lung cancer development..
11.
2020
-
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation..
11.
2020
-
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation..
11.
2020
-
Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues..
11.
2020
-
Integrative multiplatform molecular profiling of benign prostatic hyperplasia identifies distinct subtypes..
11.
2020
-
Modulation of virus-induced NF-κB signaling by NEMO coiled coil mimics..
11.
2020
-
Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability..
11.
2020
-
Sex and APOE ε4 genotype modify the Alzheimer's disease serum metabolome..
11.
2020
-
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release..
11.
2020
-
A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns..
11.
2020
-
Combined burden and functional impact tests for cancer driver discovery using DriverPower..
11.
2020
-
High-coverage whole-genome analysis of 1220 cancers reveals hundreds of genes deregulated by rearrangement-mediated cis-regulatory alterations..
11.
2020
-
Integrative pathway enrichment analysis of multivariate omics data..
11.
2020
-
Pathway and network analysis of more than 2500 whole cancer genomes..
11.
2020
-
Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF..
11.
2020
-
Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements..
11.
2020
-
Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms..
11.
2020
-
A network analysis to identify mediators of germline-driven differences in breast cancer prognosis..
11.
2020
-
The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction..
11.
2020
-
Annexin-V stabilizes membrane defects by inducing lipid phase transition..
11.
2020
-
BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins..
11.
2020
-
Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits..
11.
2020
-
ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
2020
-
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection..
10.
2019
-
Molecular determinants of nephron vascular specialization in the kidney..
10.
2019
-
Conformational pathway provides unique sensitivity to a synaptic mGluR..
10.
2019
-
Gut uropathogen abundance is a risk factor for development of bacteriuria and urinary tract infection..
10.
2019
-
A Bayesian machine learning approach for drug target identification using diverse data types..
10.
2019
-
Mapping the perturbome network of cellular perturbations..
10.
2019
-
Antibody cross-reactivity accounts for widespread appearance of m1A in 5'UTRs..
10.
2019
-
Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca2+-bound nhTMEM16..
10.
2019
-
Plasticity of the Mycobacterium tuberculosis respiratory chain and its impact on tuberculosis drug development..
10.
2019
-
Colonizing multidrug-resistant bacteria and the longitudinal evolution of the intestinal microbiome after liver transplantation..
10.
2019
-
Engineering transferrable microvascular meshes for subcutaneous islet transplantation..
10.
2019
-
Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23..
10.
2019
-
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program..
10.
2019
-
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle..
10.
2019
-
Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells..
10.
2019
-
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations..
10.
2019
-
Accurate detection of m6A RNA modifications in native RNA sequences..
10.
2019
-
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K..
10.
2019
-
Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences..
10.
2019
-
Wilm's tumor 1 promotes memory flexibility..
10.
2019
-
Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis..
10.
2019
-
IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation..
10.
2019
-
Alternative splicing regulates stochastic NLRP3 activity..
10.
2019
-
Predictive metabolomic profiling of microbial communities using amplicon or metagenomic sequences..
10.
2019
-
Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling..
10.
2019
-
Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis..
10.
2019
-
Activating an anterior nucleus gigantocellularis subpopulation triggers emergence from pharmacologically-induced coma in rodents..
10.
2019
-
Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression..
10.
2019
-
Chromatin organization in the female mouse brain fluctuates across the oestrous cycle..
10.
2019
-
Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases..
10.
2019
-
HIV-1 DNA sequence diversity and evolution during acute subtype C infection..
10.
2019
-
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia..
10.
2019
-
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence..
10.
2019
-
Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus..
10.
2019
-
Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease..
10.
2019
-
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL..
10.
2019
-
Microtubule end conversion mediated by motors and diffusing proteins with no intrinsic microtubule end-binding activity..
10.
2019
-
Breast cancer quantitative proteome and proteogenomic landscape..
10.
2019
-
Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer..
10.
2019
-
ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression..
10.
2019
-
Reversible histone glycation is associated with disease-related changes in chromatin architecture..
10.
2019
-
Restoration of high-sensitivity and adapting vision with a cone opsin..
10.
2019
-
Flagellar cAMP signaling controls trypanosome progression through host tissues..
10.
2019
-
Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response..
10.
2019
-
Capturing the inherent structural dynamics of the HIV-1 envelope glycoprotein fusion peptide..
10.
2019
-
Single-molecule sequencing detection of N6-methyladenine in microbial reference materials..
10.
2019
-
The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors..
10.
2019
-
Caveolin-1 mediates cellular distribution of HER2 and affects trastuzumab binding and therapeutic efficacy..
9.
2018
-
High-speed AFM height spectroscopy reveals µs-dynamics of unlabeled biomolecules..
9.
2018
-
Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment..
9.
2018
-
Inflammation-induced Id2 promotes plasticity in regulatory T cells..
9.
2018
-
Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics..
9.
2018
-
Testicular endothelial cells are a critical population in the germline stem cell niche..
9.
2018
-
ZZ-dependent regulation of p62/SQSTM1 in autophagy..
9.
2018
-
HSP90-incorporating chaperome networks as biosensor for disease-related pathways in patient-specific midbrain dopamine neurons..
9.
2018
-
A missense variant in SLC39A8 is associated with severe idiopathic scoliosis..
9.
2018
-
Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism..
9.
2018
-
Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer..
9.
2018
-
Bone protection by inhibition of microRNA-182..
9.
2018
-
An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel..
9.
2018
-
Genus-wide sequencing supports a two-locus model for sex-determination in Phoenix..
9.
2018
-
Mechanism-based rescue of Munc18-1 dysfunction in varied encephalopathies by chemical chaperones..
9.
2018
-
Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function..
9.
2018
-
The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice..
9.
2018
-
Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis..
9.
2018
-
Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase..
9.
2018
-
Simplified ChIP-exo assays..
9.
2018
-
Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b..
9.
2018
-
Discovery of a drug candidate for GLIS3-associated diabetes..
9.
2018
-
Urinary cell-free DNA is a versatile analyte for monitoring infections of the urinary tract..
9.
2018
-
Patient derived organoids to model rare prostate cancer phenotypes..
9.
2018
-
Finding influential nodes for integration in brain networks using optimal percolation theory..
9.
2018
-
Resolving molecule-specific information in dynamic lipid membrane processes with multi-resonant infrared metasurfaces..
9.
2018
-
Male germ cells support long-term propagation of Zika virus..
9.
2018
-
Targetable vulnerabilities in T- and NK-cell lymphomas identified through preclinical models..
9.
2018
-
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas..
9.
2018
-
Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma..
9.
2018
-
Feed-forward alpha particle radiotherapy ablates androgen receptor-addicted prostate cancer..
9.
2018
-
Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28..
9.
2018
-
Distinct molecular pathways mediate Mycn and Myc-regulated miR-17-92 microRNA action in Feingold syndrome mouse models..
9.
2018
-
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors..
9.
2018
-
Early circulating tumor DNA dynamics and clonal selection with palbociclib and fulvestrant for breast cancer..
9.
2018
-
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis..
9.
2018
-
Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation..
9.
2018
-
Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models..
9.
2018
-
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α..
9.
2018
-
Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population..
9.
2018
-
A general and flexible method for signal extraction from single-cell RNA-seq data..
9.
2018
-
A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport..
9.
2018
-
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis..
9.
2018
-
Improved split fluorescent proteins for endogenous protein labeling.
8:1-11.
2018
-
EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer..
8.
2017
-
Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor..
8.
2017
-
Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes..
8.
2017
-
Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes..
8.
2017
-
Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway..
8.
2017
-
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology..
8.
2017
-
mTOR intersects antibody-inducing signals from TACI in marginal zone B cells..
8.
2017
-
Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions..
8.
2017
-
The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions..
8.
2017
-
TRIM29 promotes DNA virus infections by inhibiting innate immune response..
8.
2017
-
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop..
8.
2017
-
An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses..
8.
2017
-
Alveolar macrophages are critical for broadly-reactive antibody-mediated protection against influenza A virus in mice..
8.
2017
-
A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice..
8.
2017
-
Stromal and epithelial transcriptional map of initiation progression and metastatic potential of human prostate cancer..
8.
2017
-
ATRX is a regulator of therapy induced senescence in human cells..
8.
2017
-
Extrinsic mechanical forces mediate retrograde axon extension in a developing neuronal circuit..
8.
2017
-
Ex vivo pretreatment of human vessels with siRNA nanoparticles provides protein silencing in endothelial cells..
8.
2017
-
Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy..
8.
2017
-
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine..
8.
2017
-
Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target..
8.
2017
-
Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis..
8.
2017
-
Inherited determinants of early recurrent somatic mutations in prostate cancer..
8.
2017
-
DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity..
8.
2017
-
Correspondence: DNA shape is insufficient to explain binding..
8.
2017
-
Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors..
8.
2017
-
An integrated model for detecting significant chromatin interactions from high-resolution Hi-C data..
8.
2017
-
A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages..
8.
2017
-
Depleting Mycobacterium tuberculosis of the transcription termination factor Rho causes pervasive transcription and rapid death..
8.
2017
-
Connecting genetic risk to disease end points through the human blood plasma proteome..
8.
2017
-
Post-endocytic sorting of Plexin-D1 controls signal transduction and development of axonal and vascular circuits..
8.
2017
-
SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts..
8.
2017
-
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity..
8.
2017
-
Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma..
8.
2017
-
THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors..
8.
2017
-
Sox17 drives functional engraftment of endothelium converted from non-vascular cells..
8.
2017
-
Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis..
7.
2016
-
Temporal stability and molecular persistence of the bone marrow plasma cell antibody repertoire..
7.
2016
-
Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets..
7.
2016
-
Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants..
7.
2016
-
FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase..
7.
2016
-
Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels..
7.
2016
-
TP53 mutations emerge with HDM2 inhibitor SAR405838 treatment in de-differentiated liposarcoma..
7.
2016
-
PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis..
7.
2016
-
Deconvoluting hepatic processing of carbon nanotubes..
7.
2016
-
Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal..
7.
2016
-
Nanoreporter PET predicts the efficacy of anti-cancer nanotherapy..
7.
2016
-
Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics..
7.
2016
-
A method to rapidly create protein aggregates in living cells..
7.
2016
-
Dynamic changes in neural circuitry during adolescence are associated with persistent attenuation of fear memories..
7.
2016
-
The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells..
7.
2016
-
Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms..
7.
2016
-
Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation..
7.
2016
-
Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease..
7.
2016
-
Laminin regulates PDGFRβ(+) cell stemness and muscle development..
7.
2016
-
Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells..
7.
2016
-
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer..
7.
2016
-
Reconstruction and topological characterization of the sigma factor regulatory network of Mycobacterium tuberculosis..
7.
2016
-
The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures..
7.
2016
-
FAT1 mutations cause a glomerulotubular nephropathy..
7.
2016
-
MSI2 is required for maintaining activated myelodysplastic syndrome stem cells..
7.
2016
-
Self-renewal of CD133(hi) cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer..
7.
2016
-
Genome-wide association and high-resolution phenotyping link Oryza sativa panicle traits to numerous trait-specific QTL clusters..
7.
2016
-
Microbial metabolomics in open microscale platforms..
7.
2016
-
Open access resources for genome-wide association mapping in rice..
7.
2016
-
Genome assembly and geospatial phylogenomics of the bed bug Cimex lectularius..
7.
2016
-
Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish..
7.
2016
-
Bcl-xL promotes metastasis independent of its anti-apoptotic activity..
7.
2016
-
CLIC4 regulates apical exocytosis and renal tube luminogenesis through retromer- and actin-mediated endocytic trafficking..
7.
2016
-
miRNA-target chimeras reveal miRNA 3'-end pairing as a major determinant of Argonaute target specificity..
6.
2015
-
Cerebrospinal fluid-derived circulating tumour DNA better represents the genomic alterations of brain tumours than plasma..
6.
2015
-
Whole genome re-sequencing of date palms yields insights into diversification of a fruit tree crop..
6.
2015
-
Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike..
6.
2015
-
Calcium ions open a selectivity filter gate during activation of the MthK potassium channel..
6.
2015
-
GITR subverts Foxp3(+) Tregs to boost Th9 immunity through regulation of histone acetylation..
6.
2015
-
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis..
6.
2015
-
Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke..
6.
2015
-
Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions..
6.
2015
-
PTEN regulates DNA replication progression and stalled fork recovery..
6.
2015
-
IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection..
6.
2015
-
Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization..
6.
2015
-
FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization..
6.
2015
-
Id1 suppresses anti-tumour immune responses and promotes tumour progression by impairing myeloid cell maturation..
6.
2015
-
Coupled local translation and degradation regulate growth cone collapse..
6.
2015
-
Epigenomic evolution in diffuse large B-cell lymphomas..
6.
2015
-
miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β..
6.
2015
-
Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy..
6.
2015
-
Identification of FOXM1 as a therapeutic target in B-cell lineage acute lymphoblastic leukaemia..
6.
2015
-
FAAH genetic variation enhances fronto-amygdala function in mouse and human..
6.
2015
-
Predicting clinical response to anticancer drugs using an ex vivo platform that captures tumour heterogeneity..
6.
2015
-
Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env..
6.
2015
-
Annexin A2 promotes phagophore assembly by enhancing Atg16L⁺ vesicle biogenesis and homotypic fusion..
6.
2015
-
Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery..
6.
2015
-
The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch..
5.
2014
-
ERG induces taxane resistance in castration-resistant prostate cancer..
5.
2014
-
The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer..
5.
2014
-
Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation..
5.
2014
-
Microwave purification of large-area horizontally aligned arrays of single-walled carbon nanotubes..
5.
2014
-
The key role of transient receptor potential melastatin-2 channels in amyloid-β-induced neurovascular dysfunction..
5.
2014
-
Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk..
5.
2014
-
Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines..
5.
2014
-
Constitutive phospholipid scramblase activity of a G protein-coupled receptor..
5.
2014
-
Assessing technical performance in differential gene expression experiments with external spike-in RNA control ratio mixtures..
5.
2014
-
Activation of diverse signalling pathways by oncogenic PIK3CA mutations..
5.
2014
-
Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation..
5.
2014
-
Membrane curvature sensing by the C-terminal domain of complexin..
5.
2014
-
Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice..
5.
2014
-
Neuroplasticity-based computerized cognitive remediation for treatment-resistant geriatric depression..
5.
2014
-
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis..
5.
2014
-
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity..
5.
2014
-
Sema3E/PlexinD1 regulates the migration of hem-derived Cajal-Retzius cells in developing cerebral cortex..
5.
2014
-
The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism..
5.
2014
-
Restricted VH/VL usage and limited mutations in gluten-specific IgA of coeliac disease lesion plasma cells..
5.
2014
-
Transient expression of Bcl6 is sufficient for oncogenic function and induction of mature B-cell lymphoma..
5.
2014
-
Mid-range Ca2+ signalling mediated by functional coupling between store-operated Ca2+ entry and IP3-dependent Ca2+ release..
5.
2014
-
MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration..
5.
2014
-
Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids..
5.
2014
-
MTSS1 is a metastasis driver in a subset of human melanomas..
5.
2014
-
2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity..
5.
2014
-
Environment-responsive nanophores for therapy and treatment monitoring via molecular MRI quenching..
5.
2014
-
A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages..
5.
2014
-
Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon..
5.
2014
-
Kinase fusions are frequent in Spitz tumours and spitzoid melanomas..
5.
2014
-
Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1..
5.
2014
-
Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle..
5.
2014
-
A hybrid high-speed atomic force-optical microscope for visualizing single membrane proteins on eukaryotic cells..
4.
2013
-
Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel..
4.
2013
-
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer..
4.
2013
-
Equilibrium selectivity alone does not create K+-selective ion conduction in K+ channels..
4.
2013
-
Identification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31..
4.
2013
-
InVERT molding for scalable control of tissue microarchitecture..
4.
2013
-
RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription..
4.
2013
-
Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction..
4.
2013
-
Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression..
3.
2012
-
Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris..
3.
2012
-
Evidence of an inhibitory restraint of seizure activity in humans..
3.
2012
-
Multiplexed volumetric bar-chart chip for point-of-care diagnostics..
3.
2012
-
Genome-wide association mapping reveals a rich genetic architecture of complex traits in Oryza sativa..
2.
2011
-
Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling..
2.
2011
-
Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17..
2.
2011
-
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells..
2.
2011
-
A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors..
1.
2010
-
Protective alleles and precision healthcare in crewed spaceflight.
2024
-
Astronaut omics and the impact of space on the human body at scale.
2024
-
Ethical considerations for the age of non-governmental space exploration.
2024
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