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Blackbird: structural variant detection using synthetic and low-coverage long-reads. 2024
Single-cell analyses reveal that monocyte gene expression profiles influence HIV-1 reservoir size in acutely treated cohorts. 2024
Sugar phosphate-mediated inhibition of peptidoglycan precursor synthesis. 2024
A high-content microscopy drug screening platform for regulators of the extracellular digestion of lipoprotein aggregates by macrophages. 2024
C3aR1 on β cells enhances β cell function and survival. 2024
Functionally important binding site for a volatile anesthetic in a voltage-gated sodium channel identified by X-ray crystallography. 2024
PAIRWISE: Deep Learning-based Prediction of Effective Personalized Drug Combinations in Cancer. 2024
The MRAP2 accessory protein directly interacts with melanocortin-3 receptor to enhance signaling. 2024
Assessing the Biosecurity Risk of Footwear as a Fomite for Transmission of Adventitious Infectious Agents to Mice. 2024
An IFN-STAT1-CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk During Aspergillus fumigatus Infection. 2024
A Transcriptional Signature of Induced Neurons Differentiates Virologically Suppressed People Living With HIV from People Without HIV. 2024
Chromatin Buffers Torsional Stress During Transcription. 2024
Gut bacteria-derived succinate induces enteric nervous system regeneration. 2024
Torsion is a Dynamic Regulator of DNA Replication Stalling and Reactivation. 2024
Transient proliferation by reversible YAP-mediated increase of the cyclin D1/p27 ratio. 2024
DNA polymerase ζ is a robust reverse transcriptase. 2024
MALT1 protease inhibition restrains glioblastoma progression by reversing tumor-associated macrophage-dependent immunosuppression. 2024
Senataxin and DNA-PKcs Redundantly Promote Non-Homologous End Joining Repair of DNA Double Strand Breaks During V(D)J Recombination. 2024
A one-step protocol to generate impermeable fluorescent HaloTag substrates for in situ live cell application and super-resolution imaging. 2024
Scalable Hypothalamic Arcuate Neuron Differentiation from Human Pluripotent Stem Cells Suitable for Modeling Metabolic and Reproductive Disorders. 2024
Mechanistic studies of mycobacterial glycolipid biosynthesis by the mannosyltransferase PimE. 2024
Structural insights into terminal arabinosylation biosynthesis of the mycobacterial cell wall arabinan. 2024
The Precise Basecalling of Short-Read Nanopore Sequencing. 2024
Predicting Task Activation Maps from Resting-State Functional Connectivity using Deep Learning. 2024
Structural basis of the excitatory amino acid transporter 3 substrate recognition. 2024
Systemic in utero gene editing as a treatment for cystic fibrosis. 2024
Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder. 2024
HLA-E and NKG2A Mediate Resistance to M. bovis BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer. 2024
Inferring cancer type-specific patterns of metastatic spread. 2024
Suppression by RNA Polymerase I Inhibitors Varies Greatly Between Distinct RNA Polymerase I Transcribed Genes in Malaria Parasites. 2024
CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism. 2024
Tumor suppressor heterozygosity and homologous recombination deficiency mediate resistance to front-line therapy in breast cancer. 2024
Tracking clonal evolution of drug resistance in ovarian cancer patients by exploiting structural variants in cfDNA. 2024
Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology. 2024
RNA tertiary structure and conformational dynamics revealed by BASH MaP. 2024
Restraint of melanoma progression by cells in the local skin environment. 2024
PURE-seq identifies Egr1 as a Potential Master Regulator in Murine Aging by Sequencing Long-Term Hematopoietic Stem Cells. 2024
Productive mRNA Chromatin Escape is Promoted by PRMT5 Methylation of SNRPB. 2024
Structure and function of the human apoptotic scramblase Xkr4. 2024
Discovery of ICOS-targeted small molecules using affinity selection mass spectrometry screening. 2024
High-grade serous ovarian cancer development and anti-PD-1 resistance is driven by IRE1α activity in neutrophils. 2024
Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection. 2024
A familial, telomere-to-telomere reference for human de novo mutation and recombination from a four-generation pedigree. 2024
Engineered NKG2C ⁺ NK-like T cells exhibit superior antitumor efficacy while mitigating cytokine release syndrome. 2024
Mechanism of neurodegeneration mediated by clonal inflammatory microglia. 2024
Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings. 2024
The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization. 2024
Transiently boosting Vγ9+Vδ2+ γδ T cells early in Mtb coinfection of SIV-infected juvenile macaques does not improve Mtb host resistance. 2024
Amyloid fibril structures link CHCHD10 and CHCHD2 to neurodegeneration. 2024
Chlamydia muridarum Causes Persistent Subclinical Infection and Elicits Innate and Adaptive Immune Responses in C57BL/6J, BALB/cJ and J:ARC(S) Mice Following Exposure to Shedding Mice. 2024
A Single Trophoblast Layer Acts as the Gatekeeper at the Endothelial-Hematopoietic Crossroad in the Placenta. 2024
Langerhans cells regulate immunity in adulthood by regulating postnatal dermal lymphatic development. 2024
GATA6 regulates WNT and BMP programs to pattern precardiac mesoderm during the earliest stages of human cardiogenesis. 2024
Polycystin-1 loss of function increases susceptibility to atrial fibrillation through impaired DNA damage response. 2024
RBM10 loss induces aberrant splicing of cytoskeletal and extracellular matrix mRNAs and promotes metastatic fitness. 2024
Cerebellar output neurons impair non-motor behaviors by altering development of extracerebellar connectivity. 2024
Epigenetic regulation by TET1 in gene-environmental interactions influencing susceptibility to congenital malformations. 2024
Anatomical and functional analysis of the corticospinal tract in an FRDA mouse model. 2024
e3SIM: epidemiological-ecological-evolutionary simulation framework for genomic epidemiology. 2024
A widespread electrical brain network encodes anxiety in health and depressive states. 2024
Genetic variation modulates susceptibility to aberrant DNA hypomethylation and imprint deregulation in naïve pluripotent stem cells. 2024
Assessment of Antimicrobial Therapy in Eradicating Chlamydia muridarum in Research Mice: Immune Status and its Impact on Outcomes. 2024
Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis. 2024
Layer Va neurons, as major presynaptic partners of corticospinal neurons, play critical roles in skilled movements. 2024
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumors. 2024
An intricate balancing act: Upstream and downstream frameshift co-regulatory elements. 2024
Forelimb motor recovery by modulating extrinsic and intrinsic signaling as well as neuronal activity after the cervical spinal cord injury. 2024
Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis. 2024
A minimally invasive thrombotic stroke model to study circadian rhythm in awake mice. 2024
Genomic characterization of Escherichia coli harbor a polyketide synthase ( pks ) island associated with colorectal cancer (CRC) development. 2024
Liver-specific Mettl14 deletion induces nuclear heterotypia and dysregulates RNA export machinery. 2024
A nucleosome switch primes Hepatitis B Virus infection. 2024
Akt2 deficiency impairs Th17 differentiation, augments Th2 differentiation, and alters the peripheral response to immunization. 2024
Characterization of β-Hydroxybutyrate as a Cell Autonomous Fuel for Active Excitatory and Inhibitory Neurons. 2024
A phosphorylation-controlled switch confers cell cycle-dependent protein relocalization. 2024
Assessing the impact of autologous neutralizing antibodies on rebound dynamics in postnatally SHIV-infected ART-treated infant rhesus macaques. 2024
TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer. 2024
A genome-wide association study of mass spectrometry proteomics using the Seer Proteograph platform. 2024
Molecular and functional alterations in the cerebral microvasculature in an optimized mouse model of sepsis-associated cognitive dysfunction. 2024
LRRK2 G2019S variant is associated with transcriptional changes in Parkinson's disease human myeloid cells under proinflammatory environment. 2024
Transcriptional remodeling by OTX2 directs specification and patterning of mammalian definitive endoderm. 2024
Oxydifficidin, a potent Neisseria gonorrhoeae antibiotic due to DedA assisted uptake and ribosomal protein RplL sensitivity. 2024
Comparative Analysis of Within-Host Dynamics of Acute Infection and Viral Rebound Dynamics in Postnatally SHIV-Infected ART-Treated Infant Rhesus Macaques. 2024
Genotype-to-phenotype mapping of somatic clonal mosaicism via single-cell co-capture of DNA mutations and mRNA transcripts. 2024
Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response. 2024
RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome Stability. 2024
Regulatory T cells restrain skin inflammation by modulating peripheral neuron activation. 2024
eIF4A controls translation of estrogen receptor alpha and is a therapeutic target in advanced breast cancer. 2024
Clinicogenomic characterization of inflammatory breast cancer. 2024
Epigenetic targeting of PGBD5-dependent DNA damage in SMARCB1-deficient sarcomas. 2024
APOBEC3 mutagenesis drives therapy resistance in breast cancer. 2024
Electrophysiological responses to appetitive and consummatory behavior in the rostral nucleus tractus solitarius in awake, unrestrained rats. 2024
CRISPR Screening Uncovers a Long-Range Enhancer for ONECUT1 in Pancreatic Differentiation and Links a Diabetes Risk Variant. 2024
Transcription of HIV-1 at sites of intact latent provirus integration. 2024
APOE3 - R136S mutation confers resilience against tau pathology via cGAS-STING-IFN inhibition. 2024
Exploring the PET in vivo generator ¹³⁴Ce as a theranostic match for ²²⁵Ac. 2024
Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder. 2024
The Dorsal Column Nuclei Scale Mechanical Sensitivity in Naive and Neuropathic Pain States. 2024
A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies. 2024
Commensal bacteria inhibit viral infections via a tryptophan metabolite. 2024
Loss of circulating CD8α⁺ NK cells during human Mycobacterium tuberculosis infection. 2024
Tumorigenesis driven by the BRAF^V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion. 2024
Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism. 2024
Inhibitory control of locomotor statistics in walking Drosophila. 2024
Chronic alcohol consumption alters sex-dependent BNST neuron function in rhesus macaques. 2024
Release the Krakencoder: A unified brain connectome translation and fusion tool. 2024
Chalkophore mediated respiratory oxidase flexibility controls M. tuberculosis virulence. 2024
Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies. 2024
The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1. 2024
Endogenous CD28 drives CAR T cell responses in multiple myeloma. 2024
ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity. 2024
Na_V1.7 targeted fluorescence imaging agents for nerve identification during intraoperative procedures. 2024
Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers. 2024
Onco-Circuit Addiction and Onco-Nutrient mTORC1 Signaling Vulnerability in a Model of Aggressive T Cell Malignancy. 2024
Molecular characterization of Rft1, a membrane protein associated with congenital disorder of glycosylation type 1N. 2024
Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia. 2024
Identification of a proteolysis regulator for an essential enzyme in Mycobacterium tuberculosis. 2024
Mesenchymal Stromal Cell Senescence Induced by Dnmt3a -Mutant Hematopoietic Cells is a Targetable Mechanism Driving Clonal Hematopoiesis and Initiation of Hematologic Malignancy. 2024
Abolished frameshifting for predicted structure-stabilizing SARS-CoV-2 mutants: Implications to alternative conformations and their statistical structural analyses. 2024
Functional phases define the response of the soil microbiome to environmental change. 2024
Analysis of gliomas DNA methylation: Assessment of pre-analytical variables. 2024
Transcript-specific enrichment enables profiling rare cell states via scRNA-seq. 2024
Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses. 2024
Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness. 2024
Interplay of IGF1R and estrogen signaling regulates hematopoietic stem and progenitor cells. 2024
Microbial cancer immunotherapy reprograms hematopoietic stem cells to enhance anti-tumor immunity. 2024
Timing of treatment shapes the path to androgen receptor signaling inhibitor resistance in prostate cancer. 2024
BET inhibitors as a therapeutic intervention in gastrointestinal gene signature-positive castration-resistant prostate cancer. 2024
Transcriptional plasticity of virulence genes provides malaria parasites with greater adaptive capacity for avoiding host immunity. 2024
Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation. 2024
A Novel Humanized Mouse Model for HIV and Tuberculosis Co-infection Studies. 2024
N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine. 2024
The sodium-proton exchangers sNHE and NHE1 control plasma membrane hyperpolarization in mouse sperm. 2024
Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior. 2024
Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB. 2024
CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit. 2024
Khdc3 Regulates Metabolism Across Generations in a DNA-Independent Manner. 2024
A Lung Cancer Mouse Model Database. 2024
Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast. 2024
Controlling the human connectome with spatially diffuse input signals. 2024
Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity. 2024
ScISOr-ATAC reveals convergent and divergent splicing and chromatin specificities between matched cell types across cortical regions, evolution, and in Alzheimer's Disease. 2024
Canonical AREs are tumor suppressive regulatory elements in the prostate. 2024
Mechanisms of Epigenomic and Functional Convergence Between Glucocorticoid and IL4-Driven Macrophage Programming. 2024
Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties. 2024
Functional Characterisation of the ATOH1 Molecular Subtype Indicates a Pro-Metastatic Role in Small Cell Lung Cancer. 2024
A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions. 2024
HIV-1 Mediated Cortical Actin Disruption Mirrors ARP2/3 Defects Found in Primary T Cell Immunodeficiencies. 2024
The Bacillus subtilis yqgC - sodA operon protects magnesium-dependent enzymes by supporting manganese efflux. 2024
Chromatin structure and var2csa - a tango in regulation of var gene expression in the human malaria parasite, Plasmodium falciparum ? 2024
Untargeted Pixel-by-Pixel Imaging of Metabolite Ratio Pairs as a Novel Tool for Biomedical Discovery in Mass Spectrometry Imaging. 2024
Cooperativity of c-MYC with Krüppel-Like Factor 6 Splice Variant 1 induces phenotypic plasticity and promotes prostate cancer progression and metastasis. 2024
Task Activation Results in Regional ¹³ C-Lactate Signal Increase in the Human Brain. 2024
Harnessing the regenerative potential of interleukin11 to enhance heart repair. 2024
A microglia clonal inflammatory disorder in Alzheimer's Disease. 2024
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. 2024
Nr4a2 blocks oAβ-mediated synaptic plasticity dysfunction and ameliorates spatial memory deficits in the APP _Sw,Ind mouse. 2024
Atacama Clear for Complex 3D Imaging of Organs. 2024
Cryo-EM analysis on magnetic beads for scarce macromolecules in heterogeneous samples. 2024
Integrative genomic analysis identifies unique immune environments associated with immunotherapy response in diffuse large B cell lymphoma. 2024
Projection-Targeted Photopharmacology Reveals Distinct Anxiolytic Roles for Presynaptic mGluR2 in Prefrontal- and Insula-Amygdala Synapses. 2024
Age-Related Decline in BBB Function is More Pronounced in Males than Females. 2024
A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification. 2024
Charting Single Cell Lineage Dynamics and Mutation Networks via Homing CRISPR. 2024
GM-CSF-mediated epithelial-immune cell crosstalk orchestrates pulmonary immunity to Aspergillus fumigatus. 2024
Germinal Center Cytokines Driven Epigenetic Control of Epstein-Barr Virus Latency Gene Expression. 2024
SAXS/MC studies of the mixed-folded protein Cdt1 reveal monomeric, folded over conformations. 2024
CRISPRmap: Sequencing-free optical pooled screens mapping multi-omic phenotypes in cells and tissue. 2024
DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility. 2024
The brainstem's red nucleus was evolutionarily upgraded to support goal-directed action. 2024
Solid tumor growth depends on an intricate equilibrium of malignant cell states. 2023
A single-cell transposable element atlas of human cell identity. 2023
Metabolomics profiling reveals distinct, sex-specific signatures in the serum and brain metabolomes in the mouse models of Alzheimer's disease. 2023
Egr1 is a sex-specific regulator of neuronal chromatin, synaptic plasticity, and behaviour. 2023
Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology. 2023
Learning of the same task subserved by substantially different mechanisms between patients with Body Dysmorphic Disorder and healthy individuals. 2023
Phosphatidylinositol 3-phosphate mediates Arc capsids secretion through the multivesicular body pathway. 2023
CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLS. 2023
Covalent Targeting of Splicing in T Cells. 2023
Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape for insights into Neurodegenerative Disorders. 2023
Transposable elements may enhance antiviral resistance in HIV-1 elite controllers. 2023
Retroelement-Age Clocks: Epigenetic Age Captured by Human Endogenous Retrovirus and LINE-1 DNA methylation states. 2023
The Molecular Logic of Gtr1/2 and Pib2 Dependent TORC1 Regulation in Budding Yeast. 2023
Altered neural activity in the mesoaccumbens pathway underlies impaired social reward processing in Shank3 -deficient rats. 2023
Uncoupled substrate binding underlies the evolutionary switch between Na ⁺ and H ⁺ -coupled prokaryotic aspartate transporters. 2023
Activating neutrophils by co-administration of immunogenic recombinant modified vaccinia virus Ankara and granulocyte colony-stimulating factor for the treatment of malignant peripheral nerve sheath tumor. 2023
Altered structural connectivity and functional brain dynamics in individuals with heavy alcohol use. 2023
Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection. 2023
A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors. 2023
A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques. 2023
Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression. 2023
Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model. 2023
Deep generative model deciphers derailed trajectories in acute myeloid leukemia. 2023
Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques. 2023
Divergent reward cue representations in the prefrontal cortex drive reward motivation in adolescence and adulthood. 2023
Morphine-context associative memory and locomotor sensitization in mice are modulated by sex and context in a dose-dependent manner. 2023
Rapid nongenomic estrogen signaling controls alcohol drinking behavior. 2023
Lymphatic Dysfunction Models an Autoimmune Emphysema Phenotype of Chronic Obstructive Pulmonary Disease. 2023
Temperature-driven coordination of circadian transcriptome regulation. 2023
Joint sequence & chromatin neural networks characterize the differential abilities of Forkhead transcription factors to engage inaccessible chromatin. 2023
DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity. 2023
Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization. 2023
Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity. 2023
Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images. 2023
LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase. 2023
Progesterone induces meiosis through two obligate co-receptors with PLA2 activity. 2023
Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production. 2023
Phosphoglycerate kinase 1 is a central leverage point in Parkinson's disease driven neuronal metabolic deficits. 2023
FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS. 2023
Genetic ablation of adhesion ligands averts rejection of allogeneic immune cells. 2023
Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma. 2023
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice. 2023
Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation. 2023
Advancement in Cellular Topographic and Nanoparticle Capture Imaging by High Resolution Microscopy Incorporating a Freeze-Drying and Gaseous Nitrogen-based Approach. 2023
A suite of engineered mice for interrogating psychedelic drug actions. 2023
Nuclear lamin A-associated proteins are required for centromere assembly. 2023
Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes. 2023
Single-Cell Profiling Reveals a Naive-Memory Relationship between CD56 ^bright and Adaptive Human Natural Killer Cells. 2023
A Genetically Encoded Actuator Selectively Boosts L-type Calcium Channels in Diverse Physiological Settings. 2023
Adaptation of a Mutual Exclusivity Framework to Identify Driver Mutations within Biological Pathways. 2023
Leukemic mutation FLT3-ITD is retained in dendritic cells and disrupts their homeostasis leading to expanded Th17 frequency. 2023
Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging. 2023
Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells. 2023
Mapping human natural killer cell development in pediatric tonsil by imaging mass cytometry and high-resolution microscopy. 2023
Automatic Ploidy Prediction and Quality Assessment of Human Blastocyst Using Time-Lapse Imaging. 2023
Data-driven biomarkers outperform theory-based biomarkers in predicting stroke motor outcomes. 2023
Tumor-Specific CD8 ⁺ T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating Lymphocytes. 2023
Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases. 2023
Synaptic plasticity via receptor tyrosine kinase/G protein-coupled receptor crosstalk. 2023
Niche-specific macrophage loss promotes skin capillary aging. 2023
Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases. 2023
Progressive plasticity during colorectal cancer metastasis. 2023
Isolation of the murine Glut1 deficient thalamocortical circuit: wavelet characterization and reverse glucose dependence of low and gamma frequency oscillations. 2023
Colibactin-induced genotoxicity and colorectal cancer exacerbation critically depends on adhesin-mediated epithelial binding. 2023
Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells. 2023
Rapid ionic current phenotyping (RICP) identifies mechanistic underpinnings of iPSC-CM AP heterogeneity. 2023
Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains. 2023
Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 Channel. 2023
Early life high fructose exposure disrupts microglia function and impedes neurodevelopment. 2023
Structure and function of the human mitochondrial MRS2 channel. 2023
Elevated serotonin in mouse spinal dorsal horn is pronociceptive. 2023
Expansion of a frontostriatal salience network in individuals with depression. 2023
Insertases Scramble Lipids: Molecular Simulations of MTCH2. 2023
Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization. 2023
Structural basis of closed groove scrambling by a TMEM16 protein. 2023
The HuMet Repository: Watching human metabolism at work. 2023
Vascularized tumor on a microfluidic chip to study mechanisms promoting tumor neovascularization and vascular targeted therapies. 2023
Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn. 2023
Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth. 2023
SALL4B, not targeted by IMiD, is important for SALL4-mediated tumorigenesis. 2023
Myeloid cell activation during Zika virus encephalitis predicts recovery of functional cortical connectivity. 2023
Genetic influences on motor learning and superperformance mutants revealed by random mutational survey of mouse locomotion. 2023
Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer. 2023
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation. 2023
Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment. 2023
Immunogenicity of COVID-19 vaccines and their effect on the HIV reservoir in older people with HIV. 2023
Dectin-1/CARD9-induction of the TFEB and TFE3 gene network is dispensable for phagocyte anti- Aspergillus activity in the lung. 2023
Aspergillus fumigatus cytochrome c impacts conidial survival during sterilizing immunity. 2023
Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes. 2023
Visual deprivation during mouse critical period reorganizes network-level functional connectivity. 2023
Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization. 2023
CRACD loss promotes small cell lung cancer tumorigenesis via EZH2-mediated immune evasion. 2023
Host-cell Interactions of Engineered T cell Micropharmacies. 2023
Chemotherapy-induced intestinal injury promotes Galectin-9-driven modulation of T cell function. 2023
In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1 -mutant lung cancer. 2023
Acute myeloid leukemia stratifies as two clinically relevant sphingolipidomic subtypes. 2023
Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations. 2023
The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis. 2023
Interferon ε restricts Zika virus infection in the female reproductive tract. 2023
Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibrocystic kidney disease. 2023
Impaired centrosome biogenesis in kidney stromal progenitors reduces abundance of interstitial lineages and accelerates injury-induced fibrosis. 2023
Multiple mechanisms of self-association of chemokine receptors CXCR4 and CCR5 demonstrated by deep mutagenesis. 2023
Genipin Crosslinks the Extracellular Matrix to Rescue Developmental and Degenerative Defects, and Accelerates Regeneration of Peripheral Neurons. 2023
Inference of single cell profiles from histology stains with the Single-Cell omics from Histology Analysis Framework (SCHAF). 2023
Leptomeningeal anti-tumor immunity follows unique signaling principles. 2023
Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury. 2023
GenoPipe: identifying the genotype of origin within (epi)genomic datasets. 2023
The landscape of MHC-presented phosphopeptides yields actionable shared tumor antigens for cancer immunotherapy across multiple HLA alleles. 2023
Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy. 2023
Multiplex analysis of cytokines and chemokines in persons aging with or without HIV. 2023
Radiances of Cerenkov-Emitting Isotopes on the IVIS. 2023
Natural selection differences detected in key protein domains between non-pathogenic and pathogenic Feline Coronavirus phenotypes. 2023
Integrative proteogenomics using ProteomeGenerator2. 2023
The prospect of universal coronavirus immunity: a characterization of reciprocal and non-reciprocal T cell responses against SARS-CoV2 and common human coronaviruses. 2023
IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding. 2022
RASCL: Rapid Assessment Of SARS-CoV-2 Clades Through Molecular Sequence Analysis. 2022
Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function. 2022
Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools. 2021
Molecular Pathophysiology of Cardiac Injury and Cardiac Microthrombi in Fatal COVID-19: Insights from Clinico-histopathologic and Single Nuclei RNA Sequencing Analyses. 2021
To knot or not to knot: Multiple conformations of the SARS-CoV-2 frameshifting RNA element. 2021
Prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine. 2021
A Human 3D neural assembloid model for SARS-CoV-2 infection. 2021
TMEM41B is a pan-flavivirus host factor. 2020
CoVaccine HT™ adjuvant potentiates robust immune responses to recombinant SARS-CoV-2 Spike S1 immunisation. 2020
High-resolution protein fragment interactions using AVA-Seq on a human reference set

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