bioRxiv : the preprint server for biology
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Overview
publication venue for
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Commensal bacteria inhibit viral infections via a tryptophan metabolite.
2024
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Interneuron FGF13 regulates seizure susceptibility via a sodium channel-independent mechanism.
2024
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Inhibitory control of locomotor statistics in walking Drosophila.
2024
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Chronic alcohol consumption alters sex-dependent BNST neuron function in rhesus macaques.
2024
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Release the Krakencoder: A unified brain connectome translation and fusion tool.
2024
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Distinct genomic and immunologic tumor evolution in germline TP53-driven breast cancers.
2024
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Onco-Circuit Addiction and Onco-Nutrient mTORC1 Signaling Vulnerability in a Model of Aggressive T Cell Malignancy.
2024
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Molecular characterization of Rft1, a membrane protein associated with congenital disorder of glycosylation type 1N.
2024
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Identification of a proteolysis regulator for an essential enzyme in Mycobacterium tuberculosis.
2024
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Mesenchymal Stromal Cell Senescence Induced by Dnmt3a -Mutant Hematopoietic Cells is a Targetable Mechanism Driving Clonal Hematopoiesis and Initiation of Hematologic Malignancy.
2024
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Functional phases define the response of the soil microbiome to environmental change.
2024
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Analysis of gliomas DNA methylation: Assessment of pre-analytical variables.
2024
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Senolytic CAR T cells reverse aging-associated defects in intestinal regeneration and fitness.
2024
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Interplay of IGF1R and estrogen signaling regulates hematopoietic stem and progenitor cells.
2024
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Microbial cancer immunotherapy reprograms hematopoietic stem cells to enhance anti-tumor immunity.
2024
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Cancer-associated DNA Hypermethylation of Polycomb Targets Requires DNMT3A Dual Recognition of Histone H2AK119 Ubiquitination and the Nucleosome Acidic Patch.
2024
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Transcriptional plasticity of virulence genes provides malaria parasites with greater adaptive capacity for avoiding host immunity.
2024
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Tuft cell IL-17RB restrains IL-25 bioavailability and reveals context-dependent ILC2 hypoproliferation.
2024
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A Novel Humanized Mouse Model for HIV and Tuberculosis Co-infection Studies.
2024
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N-acetylation of α-synuclein enhances synaptic vesicle clustering mediated by α-synuclein and lysophosphatidylcholine.
2024
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The sodium-proton exchangers sNHE and NHE1 control plasma membrane hyperpolarization in mouse sperm.
2024
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Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior.
2024
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Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB.
2024
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CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit.
2024
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Khdc3 Regulates Metabolism Across Generations in a DNA-Independent Manner.
2024
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A Lung Cancer Mouse Model Database.
2024
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Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast.
2024
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Controlling the human connectome with spatially diffuse input signals.
2024
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Rhesus Cytomegalovirus-encoded Fcγ-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity.
2024
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ScISOr-ATAC reveals convergent and divergent splicing and chromatin specificities between matched cell types across cortical regions, evolution, and in Alzheimer's Disease.
2024
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Canonical AREs are tumor suppressive regulatory elements in the prostate.
2024
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Mechanisms of Epigenomic and Functional Convergence Between Glucocorticoid and IL4-Driven Macrophage Programming.
2024
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Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties.
2024
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Functional Characterisation of the ATOH1 Molecular Subtype Indicates a Pro-Metastatic Role in Small Cell Lung Cancer.
2024
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A ratiometric ER calcium sensor for quantitative comparisons across cell types and subcellular regions.
2024
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HIV-1 Mediated Cortical Actin Disruption Mirrors ARP2/3 Defects Found in Primary T Cell Immunodeficiencies.
2024
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The Bacillus subtilis yqgC - sodA operon protects magnesium-dependent enzymes by supporting manganese efflux.
2024
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Chromatin structure and var2csa - a tango in regulation of var gene expression in the human malaria parasite, Plasmodium falciparum ?
2024
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Untargeted Pixel-by-Pixel Imaging of Metabolite Ratio Pairs as a Novel Tool for Biomedical Discovery in Mass Spectrometry Imaging.
2024
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Cooperativity of c-MYC with Krüppel-Like Factor 6 Splice Variant 1 induces phenotypic plasticity and promotes prostate cancer progression and metastasis.
2024
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Task Activation Results in Regional 13 C-Lactate Signal Increase in the Human Brain.
2024
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Harnessing the regenerative potential of interleukin11 to enhance heart repair.
2024
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A microglia clonal inflammatory disorder in Alzheimer's Disease.
2024
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Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.
2024
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Nr4a2 blocks oAβ-mediated synaptic plasticity dysfunction and ameliorates spatial memory deficits in the APP Sw,Ind mouse.
2024
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Atacama Clear for Complex 3D Imaging of Organs.
2024
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Cryo-EM analysis on magnetic beads for scarce macromolecules in heterogeneous samples.
2024
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Integrative genomic analysis identifies unique immune environments associated with immunotherapy response in diffuse large B cell lymphoma.
2024
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Projection-Targeted Photopharmacology Reveals Distinct Anxiolytic Roles for Presynaptic mGluR2 in Prefrontal- and Insula-Amygdala Synapses.
2024
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Age-Related Decline in BBB Function is More Pronounced in Males than Females.
2024
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Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation.
2024
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Charting Single Cell Lineage Dynamics and Mutation Networks via Homing CRISPR.
2024
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GM-CSF-mediated epithelial-immune cell crosstalk orchestrates pulmonary immunity to Aspergillus fumigatus.
2024
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Germinal Center Cytokines Driven Epigenetic Control of Epstein-Barr Virus Latency Gene Expression.
2024
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The brainstem's red nucleus was evolutionarily upgraded to support goal-directed action.
2024
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Solid tumor growth depends on an intricate equilibrium of malignant cell states.
2023
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A single-cell transposable element atlas of human cell identity.
2023
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CRISPRmap: Sequencing-free optical pooled screens mapping multi-omic phenotypes in cells and tissue.
2023
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DNA replication in early mammalian embryos is patterned, predisposing lamina-associated regions to fragility.
2023
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Metabolomics profiling reveals distinct, sex-specific signatures in the serum and brain metabolomes in the mouse models of Alzheimer's disease.
2023
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Egr1 is a sex-specific regulator of neuronal chromatin, synaptic plasticity, and behaviour.
2023
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Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology.
2023
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Learning of the same task subserved by substantially different mechanisms between patients with Body Dysmorphic Disorder and healthy individuals.
2023
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CDCA7 is a hemimethylated DNA adaptor for the nucleosome remodeler HELLS.
2023
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Covalent Targeting of Splicing in T Cells.
2023
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Isolation and Lipidomic Profiling of Neuronal Lipid Droplets: Unveiling the Lipid Landscape for insights into Neurodegenerative Disorders.
2023
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Transposable elements may enhance antiviral resistance in HIV-1 elite controllers.
2023
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Retroelement-Age Clocks: Epigenetic Age Captured by Human Endogenous Retrovirus and LINE-1 DNA methylation states.
2023
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The Molecular Logic of Gtr1/2 and Pib2 Dependent TORC1 Regulation in Budding Yeast.
2023
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Altered neural activity in the mesoaccumbens pathway underlies impaired social reward processing in Shank3 -deficient rats.
2023
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Uncoupled substrate binding underlies the evolutionary switch between Na + and H + -coupled prokaryotic aspartate transporters.
2023
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Activating neutrophils by co-administration of immunogenic recombinant modified vaccinia virus Ankara and granulocyte colony-stimulating factor for the treatment of malignant peripheral nerve sheath tumor.
2023
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Altered structural connectivity and functional brain dynamics in individuals with heavy alcohol use.
2023
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Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection.
2023
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A cholesterol switch controls phospholipid scrambling by G protein-coupled receptors.
2023
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A "suicide" BCG strain provides enhanced immunogenicity and robust protection against Mycobacterium tuberculosis in macaques.
2023
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Transcriptional inhibition after irradiation occurs preferentially at highly expressed genes in a manner dependent on cell cycle progression.
2023
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Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model.
2023
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Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analysis Using Integrated Single Cell- and Single Nucleus-RNA Sequencing Platforms.
2023
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Deep generative model deciphers derailed trajectories in acute myeloid leukemia.
2023
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Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.
2023
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Divergent reward cue representations in the prefrontal cortex drive reward motivation in adolescence and adulthood.
2023
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Morphine-context associative memory and locomotor sensitization in mice are modulated by sex and context in a dose-dependent manner.
2023
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Rapid nongenomic estrogen signaling controls alcohol drinking behavior.
2023
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Lymphatic Dysfunction Models an Autoimmune Emphysema Phenotype of Chronic Obstructive Pulmonary Disease.
2023
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Joint sequence & chromatin neural networks characterize the differential abilities of Forkhead transcription factors to engage inaccessible chromatin.
2023
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DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.
2023
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Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization.
2023
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Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity.
2023
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Fine-tuning TrailMap: The utility of transfer learning to improve the performance of deep learning in axon segmentation of light-sheet microscopy images.
2023
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LKB1 suppresses growth and promotes the internalization of EGFR through the PIKFYVE lipid kinase.
2023
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Progesterone induces meiosis through two obligate co-receptors with PLA2 activity.
2023
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Systems-level analyses dissociate genetic regulators of reactive oxygen species and energy production.
2023
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Phosphoglycerate kinase 1 is a central leverage point in Parkinson's disease driven neuronal metabolic deficits.
2023
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FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS.
2023
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Genetic ablation of adhesion ligands averts rejection of allogeneic immune cells.
2023
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Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma.
2023
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Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice.
2023
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Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation.
2023
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Advancement in Cellular Topographic and Nanoparticle Capture Imaging by High Resolution Microscopy Incorporating a Freeze-Drying and Gaseous Nitrogen-based Approach.
2023
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A suite of engineered mice for interrogating psychedelic drug actions.
2023
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Using a function-first 'scout fragment'-based approach to develop allosteric covalent inhibitors of conformationally dynamic helicase mechanoenzymes.
2023
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Single-Cell Profiling Reveals a Naive-Memory Relationship between CD56 bright and Adaptive Human Natural Killer Cells.
2023
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A Genetically Encoded Actuator Selectively Boosts L-type Calcium Channels in Diverse Physiological Settings.
2023
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Adaptation of a Mutual Exclusivity Framework to Identify Driver Mutations within Biological Pathways.
2023
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Leukemic mutation FLT3-ITD is retained in dendritic cells and disrupts their homeostasis leading to expanded Th17 frequency.
2023
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Sex Chromosomes and Gonads Shape the Sex-Biased Transcriptomic Landscape in Tlr7-Mediated Demyelination During Aging.
2023
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Plasma membrane abundance dictates phagocytic capacity and functional crosstalk in myeloid cells.
2023
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Mapping human natural killer cell development in pediatric tonsil by imaging mass cytometry and high-resolution microscopy.
2023
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Automatic Ploidy Prediction and Quality Assessment of Human Blastocyst Using Time-Lapse Imaging.
2023
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Data-driven biomarkers outperform theory-based biomarkers in predicting stroke motor outcomes.
2023
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Tumor-Specific CD8 + T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating Lymphocytes.
2023
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Coevolution of the CDCA7-HELLS ICF-related nucleosome remodeling complex and DNA methyltransferases.
2023
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Synaptic plasticity via receptor tyrosine kinase/G protein-coupled receptor crosstalk.
2023
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Niche-specific macrophage loss promotes skin capillary aging.
2023
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Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases.
2023
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Progressive plasticity during colorectal cancer metastasis.
2023
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Isolation of the murine Glut1 deficient thalamocortical circuit: wavelet characterization and reverse glucose dependence of low and gamma frequency oscillations.
2023
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Colibactin-induced genotoxicity and colorectal cancer exacerbation critically depends on adhesin-mediated epithelial binding.
2023
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Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells.
2023
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Rapid ionic current phenotyping (RICP) identifies mechanistic underpinnings of iPSC-CM AP heterogeneity.
2023
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Control of G protein-coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains.
2023
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Early life high fructose exposure disrupts microglia function and impedes neurodevelopment.
2023
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Elevated serotonin in mouse spinal dorsal horn is pronociceptive.
2023
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Expansion of a frontostriatal salience network in individuals with depression.
2023
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Insertases Scramble Lipids: Molecular Simulations of MTCH2.
2023
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Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization.
2023
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Structural basis of closed groove scrambling by a TMEM16 protein.
2023
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The HuMet Repository: Watching human metabolism at work.
2023
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Vascularized tumor on a microfluidic chip to study mechanisms promoting tumor neovascularization and vascular targeted therapies.
2023
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Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth.
2023
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Myeloid cell activation during Zika virus encephalitis predicts recovery of functional cortical connectivity.
2023
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Genetic influences on motor learning and superperformance mutants revealed by random mutational survey of mouse locomotion.
2023
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Glutamine antagonist DRP-104 suppresses tumor growth and enhances response to checkpoint blockade in KEAP1 mutant lung cancer.
2023
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Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
2023
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Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment.
2023
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Immunogenicity of COVID-19 vaccines and their effect on the HIV reservoir in older people with HIV.
2023
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Dectin-1/CARD9-induction of the TFEB and TFE3 gene network is dispensable for phagocyte anti- Aspergillus activity in the lung.
2023
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Aspergillus fumigatus cytochrome c impacts conidial survival during sterilizing immunity.
2023
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DREADD-mediated amygdala activation is sufficient to induce anxiety-like responses in young nonhuman primates.
2023
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Glucose Hypometabolism Prompts RAN Translation and Exacerbates C9orf72-related ALS/FTD Phenotypes.
2023
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Visual deprivation during mouse critical period reorganizes network-level functional connectivity.
2023
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Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.
2023
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CRACD loss promotes small cell lung cancer tumorigenesis via EZH2-mediated immune evasion.
2023
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Host-cell Interactions of Engineered T cell Micropharmacies.
2023
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Chemotherapy-induced intestinal injury promotes Galectin-9-driven modulation of T cell function.
2023
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In vivo metabolomics identifies CD38 as an emergent vulnerability in LKB1 -mutant lung cancer.
2023
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Acute myeloid leukemia stratifies as two clinically relevant sphingolipidomic subtypes.
2023
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Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations.
2023
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The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis.
2023
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Interferon ε restricts Zika virus infection in the female reproductive tract.
2023
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Aberrant centrosome biogenesis disrupts nephron progenitor cell renewal and fate resulting in fibrocystic kidney disease.
2023
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Impaired centrosome biogenesis in kidney stromal progenitors reduces abundance of interstitial lineages and accelerates injury-induced fibrosis.
2023
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Genipin Crosslinks the Extracellular Matrix to Rescue Developmental and Degenerative Defects, and Accelerates Regeneration of Peripheral Neurons.
2023
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Inference of single cell profiles from histology stains with the Single-Cell omics from Histology Analysis Framework (SCHAF).
2023
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Leptomeningeal anti-tumor immunity follows unique signaling principles.
2023
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Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury.
2023
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GenoPipe: identifying the genotype of origin within (epi)genomic datasets.
2023
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Development of prefrontal corticostriatal connectivity in mice.
2023
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The landscape of MHC-presented phosphopeptides yields actionable shared tumor antigens for cancer immunotherapy across multiple HLA alleles.
2023
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Overcoming clinical resistance to EZH2 inhibition using rational epigenetic combination therapy.
2023
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Radiances of Cerenkov-Emitting Isotopes on the IVIS.
2023
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Integrative proteogenomics using ProteomeGenerator2.
2023
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IgG3 subclass antibodies recognize antigenically drifted influenza viruses and SARS-CoV-2 variants through efficient bivalent binding.
2022
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Apropos of Universal Epitope Discovery for COVID-19 Vaccines: A Framework for Targeted Phage Display-Based Delivery and Integration of New Evaluation Tools.
2021
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Prophylactic protection against respiratory viruses conferred by a prototype live attenuated influenza virus vaccine.
2021
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A Human 3D neural assembloid model for SARS-CoV-2 infection.
2021
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TMEM41B is a pan-flavivirus host factor.
2020
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High-resolution protein fragment interactions using AVA-Seq on a human reference set
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